Strategies and tools for modulating

pathologic protein self-assembly


March 21-22, 2019 | Instituto de Investigação e Inovação em Saúde - i3S, University of Porto, Portugal



The workshop on “Strategies and tools for modulating pathologic protein self-assembly"  will join leading experts to discuss the current knowledge on the mechanisms underpinning self-assembly of disease-related proteins and present strategies to modulate toxic protein aggregation. Aberrant protein self-assembly is linked to over 30 human disorders, including neurodegenerative diseases, type-2 diabetes, and systemic amyloidosis. Misfolded and aggregated proteins also play a detrimental role in conditions in which clearance becomes deficient, such as lysosomal storage diseases. In addition, amyloid structures can be hijacked by viruses, e.g. HIV to increase infection. In all these conditions, a common characteristic of the proteins involved in the appearance of diverse, mostly non-native assemblies of the disease-related proteins, ranging from small oligomers to amyloid deposits. We have recently witnessed significant progress in understanding the biophysical and structural properties of these protein assemblies and in identifying their cytotoxicity mechanisms. These advances have been crucial to developing novel disease-modifying strategies and molecules. Despite this significant progress, we are still waiting for the appearance of the first effective drug designed to abrogate pathological protein self-assembly.
The advances in the field and discussion of future research paths presented in this workshop will provide a collection of articles that will be compiled in a Research Topic to be published in Frontiers in Molecular Neuroscience. We encourage the submission of innovative perspectives, reviews and original research articles on this topic that will contribute to stimulate the discussion of novel therapeutic avenues to tackle a significant number of severe human diseases.








Confirmed speakers


Maria Rosário Almeida, Ph.D. - i3S/ IBMC, ICBAS, University of Porto, Portugal

Gal Bitan, Ph.D. – UCLA

Fabrizio Chiti, Ph.D. - University of Florence, Italy

Alessandro Fraldi, Ph.D. - University of Naples "Federico II", Italy

Jan Münch, Ph.D. - Ulm University, Germany

Sheena Radford, Ph.D. - University of Leeds, United Kingdom

Sandra de Macedo Ribeiro, Ph.D. - i3S/ IBMC, University of Porto, Portugal

Thomas Schrader, Ph.D. - University of Duisburg-Essen, Germany

Nadia Stefanova, M.D., Ph.D. - Medical University, Innsbruck, Austria

Richard Wade-Martins, MA, DPhil - Oxford University, United Kingdom




Organizing Committee


Sandra de Macedo Ribeiro, i3S/ IBMC, University of Porto
Maria Rosário Almeida, i3S/ IBMC, ICBAS, University of Porto
Gal Bitan, UCLA

Abstract Submission

The deadline for abstract submission is 28th December 2018


Authors should follow the abstract layout template provided:




Abstracts will be reviewed by the organizing committee and a decision whether to accept the abstract will be sent by 10th January 2019.

During abstract submission, authors are asked to indicate whether they have a preference for oral or poster presentation






Registration fee includes coffee breaks, lunch (on 22nd March) and workshop material.







Early bird registration | Until 31st January 2019 (Payment deadline: 7th February 2019)

Regular registration: 65 €

Students and Postdocs (up to 5 years after Ph.D.)*: 35 €


Late registration |  From 1st February until 28th February 2019 (Payment deadline: 7th March 2019)

Regular registration: 100 €

Students and Postdocs (up to 5 years after Ph.D.)*: 50 €


*Students and Postdocs (up to 5 years after Ph.D.) should enclose a document confirming their status in the registration form.






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