Perpétua Pinto do Ó
Microenvironments for New Therapies
Assistant Researcher
After completing a degree in Biology and a three years research period in Pharmacology (Faculty of Medicine, Porto University/Department for Molecular Medicine, Karolinska Institute, Stockholm), Perpétua enrolled in the Gulbenkian PhD Program in Biology and Medicine (Oeiras, Portugal) in 1995. This was the opportunity to get in touch with the blooming field of stem cell biology in which she got a PhD degree from Umeå University, Sweden (1996-2002). During postdoctoral training at Instituto de Biologia Molecular e Celular-IBMC (2003-2006) got acknowledged with molecular immunology and late in 2007 became a researcher at INEB where she now leads the SCmR - Stem-Cell Microenvironments in Repair/Regeneration Team. Parallel to her long-time interest on basic stem cell biology mechanisms Pinto-do-Ó got interested on understanding the role stem/progenitor cells allocated to specific tissue/organs might have on the regeneration in the adult organism. Perpetuas Team started by using the heart as model in this investigation; a series of in vivo and in vitro tools were established that contribute for the establishment of a new research line on cardiovascular repair/regeneration at INEB. The latter is presently represented by the integrative efforts applied to identify cells/molecular cues (cellular and non-cellular, e.g. extracellular matrix) implied in heart development and cardiac tissue (re) genesis (a term we coined for adult tissue remaking/regeneration). Pinto-do-Ó has been PI of several research projects, two funded by the National Foundation for Science and Technology (FCT) adding to contract-projects with the industry while also participating in other colleagues work. While at INEB Perpetua has been supervising 2 post-doctoral-fellows; 1 PhD thesis (concluded); 4 PhD students (ongoing); 7 MSc. theses completed and 2 MSc. theses (ongoing). New research lines addressing the biology of regenerative systems, e.g. hematopoietic system (collaboration, Dr Ana Cumano, Pasteur Institut, Paris, France), are presently being launched. Pinto-do-Ó is also course responsible and lecturer of Stem Cell Biology and an Adjunct Professor at Instituto de Ciências Biomédicas Abel Salazar (ICBAS) of the University of Porto (2012-). Scientific identifiers: Scopus Author ID 6507474925; ResearcherID K-3742-2012;