Renata Freitas
Cell Growth and Differentiation
Assistant Researcher
R. Freitas studies HoxD gene function, exploring the involvement of these genes in vertebrate limb evolution. As past achievements, she characterized their ancient expression profiles in lamprey and shark appendages. She then explored how their transcriptional modulation may have potentiated the evolution of limb morphology using transgenic and functional assays in zebrafish. Among other topics, R. Freitas is currently characterizing the targets affected by the transcriptional modulation of these genes, exploring how these mechanisms may underlie human limb malformations and the establishment of the limb morphology in Vertebrates.