José Bessa
Vertebrate Development and Regeneration
Principal Researcher
JBessa completed his PhD degree in Developmental Biology at ICBAS (University of Porto; 2008), acquiring advanced knowledge in the development of Drosophila and Zebrafish visual systems, under the supervision of Dr. FCasares. As a postdoc, JBessa has joined the lab of Dr. JLGomez-Skarmeta, an expert in zebrafish Functional Genomics. Currently JBessa is developing an independent research line on transcriptional cis-regulation and gene function in the zebrafish pancreas.

Selected Publications
A Pentanucleotide ATTTC Repeat Insertion in the Non-coding Region of DAB1, Mapping to SCA37, Causes Spinocerebellar Ataxia. American Journal of Human Genetics101(1):87-103, 2017. [Journal: Article] [IF: 9 (*)]
DOI: 10.1016/j.ajhg.2017.06.007 SCOPUS: 85021415706

sox21a directs lateral line patterning by modulating FGF signaling. Developmental Neurobiology75(1):80-92, 2015. [Journal: Article] [CI: 2] [IF: 2,5]
DOI: 10.1002/dneu.22211 SCOPUS: 84919392179

Gatekeepers of pancreas: TEAD and YAP. Oncotarget6(18):15736-15737, 2015. [Journal: Editorial] [CI: 1] [IF: 5]
SCOPUS: 84937964234

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Nature Cell Biology17(5):615-626, 2015. [Journal: Article] [CI: 41] [IF: 18,7]
DOI: 10.1038/ncb3160 SCOPUS: 84928938629

Restless Legs Syndrome-Associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Research24(4):592-603, 2014. [Journal: Article] [CI: 28] [IF: 14,6]
DOI: 10.1101/gr.166751.113 SCOPUS: 84898747287

A mobile insulator system to detect and disrupt cis-regulatory landscapes in vertebrates. Genome Research24(3):487-495, 2014. [Journal: Article] [CI: 2] [IF: 14,6]
DOI: 10.1101/gr.165654.113 SCOPUS: 84895553255

Several Cis-regulatory Elements Control mRNA Stability, Translation Efficiency, and Expression Pattern of Prrxl1(Paired Related Homeobox Protein-like 1). Journal of Biological Chemistry288(51):36285-36301, 2013. [Journal: Article] [CI: 5] [IF: 4,6]
DOI: 10.1074/jbc.M113.491993 SCOPUS: 84890912110

Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression. BMC Genomics13(1):, 2012. [Journal: Article] [CI: 11] [IF: 4,4]
DOI: 10.1186/1471-2164-13-713 SCOPUS: 84871117732

Identification and analysis of conserved cis-regulatory regions of the MEIS1 gene. PLoS ONE7(3):, 2012. [Journal: Article] [CI: 10] [IF: 3,7]
DOI: 10.1371/journal.pone.0033617 SCOPUS: 84858638769

Zebrafish Enhancer Detection (ZED) vector: A new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish. Developmental Dynamics238(9):2409-2417, 2009. [Journal: Article] [CI: 75] [IF: 2,8]
DOI: 10.1002/dvdy.22051 SCOPUS: 70349085853