People
Deolinda Lima
Pain Research

Born at 1952. MD by the Faculty of Medicine of the University of Porto at 1975. PhD in Medicine - Morphological Sciences, Neuroscience at 1989. Affiliation in Neuroscience, Pain at 1994.Full professor of Molecular Biology, Histology and Embryology at the Faculty of Medicine of the University of Porto. Research was first dedicated to the morphological and neurochemical characterization of spinal nociceptive neurons and their supraspinal projection pattern, which resulted in the classification and brain connectivity characterization of marginal zone (lamina I) neurons. She then moved to functional studies through the combination of tract tracing with proto-oncogene noxious-evoked activation, behavioral testing, pharmacological evaluation and electrophysiological recording. A team dedicated to pain studies, with various contributions to the understanding of pain mechanisms, was set up. Among others, a novel bulbospinal reverberating loop promoting pain facilitation was described and the pronocicpetive role of supraspinal noradrenalin release demonstrated. She is leading pain research at IBMC/FMUP, which counts on the contribution of several PIs studying various physiopathological, clinical and social aspects of pain.

Selected Publications
Regadas I., Soares-dos-Reis R., Falcão M., Matos M., Monteiro F., Lima D., Reguenga C.,
Dual role of Tlx3 as modulator of Prrxl1 transcription and phosphorylation. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms1839(11):1121-1131, 2014. [Journal: Article] [CI: 2] [IF: 6,3]
DOI: 10.1016/j.bbagrm.2014.08.007 SCOPUS: 84907484335. .

Cardoso-Cruz H., Sousa M., Vieira J., Lima D., Galhardo V.,
Prefrontal cortex and mediodorsal thalamus reduced connectivity is associated with spatial working memory impairment in rats with inflammatory pain. Pain154(11):2397-2406, 2013. [Journal: Article] [CI: 30] [IF: 5,8]
DOI: 10.1016/j.pain.2013.07.020 SCOPUS: 84886313692. .

Cardoso-Cruz H., Lima D., Galhardo V.,
Impaired spatial memory performance in a rat model of neuropathic pain is associated with reduced hippocampus-prefrontal cortex connectivity. Journal of Neuroscience33(6):2465-2480, 2013. [Journal: Article] [CI: 50] [IF: 6,7]
DOI: 10.1523/JNEUROSCI.5197-12.2013 SCOPUS: 84873294842. .

Martins I., Costa-Araújo S., Fadel J., Wilson S., Lima D., Tavares I.,
Reversal of neuropathic pain by HSV-1-mediated decrease of noradrenaline in a pain facilitatory area of the brain. Pain151(1):137-145, 2010. [Journal: Article] [CI: 26] [IF: 5,4]
DOI: 10.1016/j.pain.2010.06.027 SCOPUS: 79952183262. .

Pinto V., Szucs P., Lima D., Safronov B.,
Multisegmental Ad- and C-fiber input to neurons in lamina I and the lateral spinal nucleus. Journal of Neuroscience30(6):2384-2395, 2010. [Journal: Article] [CI: 20] [IF: 7,3]
DOI: 10.1523/JNEUROSCI.3445-09.2010 SCOPUS: 76649088934. .

Xu Y., Lopes C., Qian Y., Liu Y., Cheng L., Goulding M., Turner E., Lima D., Ma Q.,
Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons. Journal of Neuroscience28(15):4037-4046, 2008. [Journal: Article] [CI: 37] [IF: 7,5]
DOI: 10.1523/JNEUROSCI.4126-07.2008 SCOPUS: 43049176725. .

Lima D., Almeida A.,
The medullary dorsal reticular nucleus as a pronociceptive centre of the pain control system. Progress in Neurobiology66(2):81-108, 2002. [Journal: Article] [CI: 99] [IF: 10,7]
DOI: 10.1016/S0301-0082(01)00025-9 SCOPUS: 0036200256. .

Chen Z., Rebelo S., White F., Malmberg A., Baba H., Lima D., Woolf C., Basbaum A., Anderson D.,
The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron31(1):59-73, 2001. [Journal: Article] [CI: 109] [IF: 14,2]
DOI: 10.1016/S0896-6273(01)00341-5 SCOPUS: 0034889110. .

Lima D.,
Anatomical basis for the dynamic processing of nociceptive input. European Journal of Pain (United Kingdom)2(3):195-202, 1998. [Journal: Review] [CI: 26]
DOI: 10.1016/S1090-3801(98)90015-5 SCOPUS: 0031695270. .

Lima D., Coimbra A.,
A Golgi study of the neuronal population of the marginal zone (lamina I) of the rat spinal cord. Journal of Comparative Neurology244(1):53-71, 1986. [Journal: Article] [CI: 118]
DOI: 10.1002/cne.902440105 SCOPUS: 0022591355. .