People
Isaura Tavares
Pain Research
Professor
Name: Isaura Ferreira Tavares Birth Place: 18 September 1966 Degrees: Biology -Faculdade de Ciências da Universidade do Porto (1989); PhD -Faculdade de Medicina do Porto (1998); Habilitation -Faculdade de Medicina do Porto (2007) Professional Category: Professor Associado com Agregação da Faculdade de Medicina do Porto (since 2007) Experience as supervisor: Master Thesis: 5 thesis concluded PhD Thesis- 7 thesis concluded; 5 thesis ongoing Experience in research projects as Principal Investigator: - Projecto FCT nº PTDC/SAU-NSC/110954/2009 O encéfalo na dor crónica: estudo dos mecanismos de facilitação da dor mediados por receptores opióides do tipo mu (October 2010 to October 2013). - Projecto FCT nº PTDC/SAU-OSM/64643/2006 "Diabetes and somatosensory system: effects of dysfunctions in insulin and its related peptides in painful diabetic neuropathy (October 2007- September 2010). - Project of Astra-Zeneca Foundation The central nervous system during diabetic neuropathy. (Jan 2006-Dec 2007). - Projecto FCT nº POCTI/NSE/38952/2001. Gene therapy in chronic pain control: role of the supraspinal endogenous pain control system. (September 2002-August 2005) -REDDSTAR Repair of Diabetic Damage by Stromal cell Administration. Projeto financiado pela FPF7/HEALTH -2012 -INNOVATION- 1 (nº HEALTH -F2- 2012 305736 (January 2013 - December 2016). Responsible by the Portuguese team. Papers: 1. Castro-Lopes JM, Tavares I, Tölle T, Coito A, Coimbra A. (1992). Increase in GABAergic cells and GABA levels in spinal cord in unilateral inflammation of the hindlimb in the rat. Eur. J. Neurosci., 4: 296-301. 2. Almeida A, Tavares I, Lima D, Coimbra A. (1993). Descending projections from the medullary dorsal reticular nucleus make synaptic contacts with spinal cord lamina I cells projecting to that nucleus: an electron microscopic tracer study in the rat. Neuroscience, 55: 1093-1106. 3. Castro-Lopes JM, Tavares I, Coimbra A. (1993). GABA decreases in the spinal dorsal horn after peripheral neurectomy. Brain Res., 620: 287-291. 4. Tavares I, Lima D, Coimbra A. (1993). Neurons in the superficial dorsal horn of the rat spinal cord projecting to the medullary reticular formation express c-fos after noxious stimulation of the skin. Brain Res., 623: 278-286. 5. Castro-Lopes JM, Tavares I, Tölle TR, Coimbra A. (1994). Carrageenan-induced inflammation of the hind-foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord which is prevented by peripheral neurectomy or neonatal capsaicin treatment. Pain, 56: 193-201. 6. Tavares I, Lima D. (1994). Descending projections from the caudal medulla oblongata to the superficial or deep dorsal horn of the rat spinal cord. Exp. Brain. Res., 99: 455-463. 7. Almeida A, Tavares I, Lima D. (1995). Projections sites of superficial or deep dorsal horn in the dorsal reticular nucleus. Neuroreport, 6: 1245-1248. 8. Tavares I, Albino-Teixeira A, Lima D. (1995). Hypertension inhibits noxious-evoked c-fos expression in the rat spinal cord. Neuroreport, 6: 1664-1668. 9. Tavares I, Lima D, Coimbra A. (1996). The ventrolateral medulla of the rat is connected with the spinal cord dorsal horn by an indirect descending pathway relayed in the A5 noradrenergic cell group. J. Comp. Neurol., 374: 84-95. 10. Tavares I, Lima D, Coimbra A. (1997). The pontine A5 noradrenergic cells which project to the spinal cord dorsal horn are reciprocally connected with the caudal ventrolateral medulla in the rat. Eur. J. Neurosci., 9: 2452-2461. 11. Tavares I, Almeida A, Albino-Teixeira A, Lima D. (1997). Lesions of the caudal ventrolateral medulla block the hypertension-induced inhibition of noxious-evoked c-fos expression in the rat spinal cord. Eur. J. Pain, 1: 149-16. 12. Lima D, Almeida A e Tavares I. (1998). The endogenous pain control system; Facilitating and inhibitory pathways. In: Pain Mechanisms and Management, S.N. Ayrapetyan and V. Apkarian (Eds.), IOS Press, Amsterdam, pp. 192-211. 13. Almeida A, Tavares I, Lima D. (2000). Reciprocal connections between the medullary dorsal reticular nucleus and the spinal dorsal horn in the rat. Europ. J. Pain, 4: 373-387. 14. Esteves F, Tavares I, Almeida A, Batten T, McWilliam P, Lima D. (2001) Projection sites of superficial and deep spinal dorsal horn cells in the nucleus tractus solitarii of the rat. Brain Res., 921: 195-205. 15. Almeida A, Cobos A, Tavares I, Lima D. (2002). Brain afferents to the medullary dorsal reticular nucleus: a retrograde and anterograde tracing study in the rat. Europ. J. Neurosci., 16: 81-95 16. Tavares I, Almeida A e Lima D. (2002). Tract-tracing methods at the ultrastructural level. In: Cellular and Molecular Methods in Neurobiology Research, A. Merighi e G. Carmignoto (Eds), Springer, Nova Iorque, pp. 221-234. 17. Lima D, Albino-Teixeira A e Tavares I. (2002). The caudal medullary ventrolateral reticular formation in nociceptive-cardiovascular integration. An experimental study in the rat. Exp. Physiol., 87.2: 267-274. 18. Tavares I e Lima D. (2002). The caudal ventrolateral medulla as a major inhibitory center of pain transmission at the spinal cord. J. Pain, 3: 337-346 19. Pinto M, Lima D, Castro-Lopes JM, Tavares I. (2003). Noxious-evoked c-fos expression in brainstem neurons immunoreactive for GABAB, *-opioid and NK-1 receptors. Europ. J. Neurosci., 17: 1393-1402. 20. Cobos A, Lima D, Almeida A, Tavares I. (2003). Brain afferents to the caudal ventrolateral medulla: a retrograde and anterograde tracing study in the rat. Neuroscience, 120: 485-498. 21. Castro AR, Pinto M, Lima D, Tavares I. (2004). Nociceptive spinal neurons expressing NK1 and GABAB receptors are located in lamina I. Brain Res., 1003: 77-85. 22. Castro AR, Pinto M, Lima D, Tavares I. (2005). Imbalance between the expression of NK1 and GABAB receptors in nociceptive spinal neurons during secondary hyperalgesia: a c-fos study in the monoarthritic rat. Neuroscience, 132: 905-916. 23. Castro AR, Morgado C, Lima D, Tavares I. (2006). Differential expression of NK1 and GABAB receptors in spinal neurons projecting to antinociceptive or pronociceptive medullary centers. Brain Res. Bull., 69: 266-275. 24. Morato M, Pinho D, Sousa T, Tavares I, Albino-Teixeira A. (2006). The inhibition of nociceptive responses of spinal cord neurones during hypertension involves the spinal GABAergic system and a pain modulatory center located at the caudal ventrolateral medulla. J. Neurosci. Res., 83: 647-655. 25. Pinho D, Sousa T, Morato M, Tavares I, Albino-Teixeira A. (2006). Lesion of the caudal ventrolateral medulla prevents the induction of hypertension by adenosine receptor blockade in rats. Brain Res., 1073-1074: 374-382. 26. Castro AR, Pinto M, Lima D, Tavares I. (2006). Secondary hyperalgesia in the monoarthritic rat is mediated by GABAB and NK1 receptors of spinal dorsal horn neurons: a behaviour and c-fos study. Neuroscience, 141: 2087-2095. 27. Pinto M, Lima D, Tavares I. (2006). Correlation of noxious evoked c-fos expression in areas of the somatosensory system during chronic pain: involvement of spino-medullary and intra-medullary connections. Neurosci. Lett., 409: 100-105. 28. Almeida A, Leite-Almeida H e Tavares I. (2006). Medullary control of nociceptive inputs: reciprocal communications with the spinal cord. Drug Discovery Today: Disease Mechanisms: 3 (3): 305-312 29. Morgado C, Tavares I. (2007). C-fos expression at the spinal dorsal horn of streptozotocin-induced diabetic rats. Diabetes Metab. Res. Rev., 23: 644-652. 30. Tavares I e Lima D. (2007). From neuroanatomy to gene therapy: searching for new ways to manipulate the supraspinal endogenous pain modulatory system. J. Anatomy, 211: 261-268. 31. Pinto M, Lima D, Tavares I. (2007). Neuronal activation at the spinal cord and medullary pain control centres after brief stimulation of an inflamed joint: a c-fos study in the monoarthritic rat. Neuroscience, 147:1076-1089. 32. Pinto M, Sousa M, Lima D, Tavares I. (2008) Expression of µ-opioid, GABAB and NK1 receptors in spinally-projecting neurons of the caudal medulla oblongata: implications for descending modulation of nociceptive transmission. J. Comp. Neurol., 510: 175-187. 33. Morgado C, Pinto-Ribeiro F, Tavares I. (2008). Diabetes affects the expression of GABA and potassium chloride cotransporter in the spinal cord: a study in streptozotocin diabetic rats. Neurosci. Lett., 438: 102-106. 34. Martins I, Pinto M, Lima D, Wilson SP, Tavares I. (2008). Dynamic of migration of HSV-1 from a medullary pronociceptive centre: antinociception by overexpression of the preproenkephalin transgene. Eur. J. Neurosci., 28: 2075-2083. 35. Pinto M, Castro AR, Tushdy F, Wilson SP, Lima D, Tavares I. (2008). Opioids modulate pain facilitation from the dorsal reticular nucleus. Mol. Cell Neurosci, 39: 508-518. 36. Heinricher MM, Tavares I,. Leith JL, Lumb BM. (2009) Descending control of nociception: Specificity, recruitment and plasticity. Brain Res Rev., 60:214-225. 37. Marques-Lopes J, Pinto M, Pinho D, Morato M, Patinha D, Albino-Teixeira A, Tavares I. (2009). Microinjection of angiotensin II in the caudal ventrolateral medulla induces hyperalgesia. Neuroscience, 158:1301-1310. 38. Morgado, M, Pereira-Terra P, Tavares I (2010). Neuronal hyperactivity at the spinal cord and periaqueductal grey during painful diabetic neuropathy: effects of gabapentin. Eur. J. Pain, Aug;14(7):693-9. doi: 10.1016/j.ejpain.2009.11.011.. 39. Marques-Lopes J, Pinho D, Albino-Teixeira A, Tavares I. (2010). The hyperalgesic effects induced by the injection of angiotensin II into the caudal ventrolateral medulla are mediated by the pontine A5 noradrenergic cell group. Brain Res., 1325:41-52. 40. Martins I, Araújo S, Fadel J, Wilson SP, Lima D, Tavares I. (2010).Reversal of neuropathic pain by HSV-1-mediated decrease of noradrenaline in a pain facilitatory area of the brain. Pain, 151:137-145. 41. Pinho D, Morato M,Couto MR, Marques-Lopes J, Tavares I, Albino-Teixeira A. (2010). Does chronic pain alter the normal interaction between cardiovascular and pain regulatory systems Pain modulation in the hypertensive-monoarthritic rat. J. Pain, Aug 23. [Epub ahead of print] 42. Gonçalves N, Rebelo S, Tavares I. (2010) Fetal pain: causes and consequences. Acta Med Port 23:419-426. 43. Ribeiro MM, Pinto AR, Domingues MM, Serrano I, Heras M, Bardaji ER, Tavares I, Castanho MA. Chemical conjugation of the neuropeptide kyotorphin and ibuprofen enhances brain targeting and analgesia. Mol Pharm. 2011 Oct 3;8(5):1929-40. 44. Martins I, Cabral L, Pinto A, Wilson SP, Lima D, Tavares I. Reversal of inflammatory pain by HSV-1-mediated overexpression of enkephalin in the caudal ventrolateral medulla. Eur J Pain. 2011 Nov;15(10):1008-14. 45. Morgado C, Silva L, Pereira-Terra P, Tavares I. Changes in serotoninergic and noradrenergic descending pain pathways during painful diabetic neuropathy: the preventive action of IGF1. Neurobiol Dis. 2011 Jul;43(1):275-84. 46. Morgado C, Pereira-Terra P, Tavares I. α-Lipoic acid normalizes nociceptive neuronal activity at the spinal cord of diabetic rats. Diabetes Obes Metab. 2011 Aug;13(8):736-41. 47. Ribeiro MM, Pinto A, Pinto M, Heras M, Martins I, Correia A, Bardaji E, Tavares I, Castanho M. Inhibition of nociceptive responses after systemic administration of amidated kyotorphin. Br J Pharmacol. 2011 Jul;163(5):964-73. 48. Morgado C, Pereira-Terra P, Cruz CD, Tavares I. Minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia-induced changes in the expression of the potassium chloride co-transporter 2 (KCC2) at the spinal cord. Diabetes Obes Metab. 2011 Feb;13(2):150-9. 49. Pinho D, Morato M, Couto MR, Marques-Lopes J, Tavares I, Albino-Teixeira A. Does chronic pain alter the normal interaction between cardiovascular and pain regulatory systems Pain modulation in the hypertensive-monoarthritic rat. J Pain. 2011 Feb;12(2):194-204. 50. Marques-Lopes J, Martins I, Pinho D, Morato M, Wilson SP, Albino-Teixeira A,Tavares I. Decrease in the expression of N-methyl-D-aspartate receptors in the nucleus tractus solitarii induces antinociception and increases blood pressure. J Neurosci Res. 2012 Feb;90(2):356-66. 51. Silva M, Amorim D, Almeida A, Tavares I, Pinto-Ribeiro F, Morgado C. Pronociceptive changes in the activity of rostroventromedial medulla (RVM) pain modulatory cells in the streptozotocin-diabetic rat. Brain Res Bull. 2013 Jul;96:39-44. 52. Martins I, de Vries MG, Teixeira-Pinto A, Fadel J, Wilson SP, Westerink BH, Tavares I. Noradrenaline increases pain facilitation from the brain during inflammatory pain. Neuropharmacology. 2013 Aug;71:299-307. 53. Ribeiro MM, Santos SS, Sousa DS, Oliveira M, Santos SM, Heras M, Bardaji E,Tavares I, Castanho MA. Side-effects of analgesic kyotorphin derivatives: advantages over clinical opioid drugs. Amino Acids. 2013 Jul;45(1):171-8. 54. Silva M, Amorim D, Almeida A, Tavares I, Pinto-Ribeiro F, Morgado C. Pronociceptive changes in the activity of rostroventromedial medulla (RVM) pain modulatory cells in the streptozotocin-diabetic rat. Brain Res Bull. 2013 Jul;96:39-44. doi: 10.1016/j.brainresbull.2013.04.008. Epub 2013 Apr 30. 55. Martins D, Tavares I, Morgado C. "Hotheaded": the role OF TRPV1 in brain functions. Neuropharmacology. 2014 Oct;85:151-7. doi: 10.1016/j.neuropharm.2014.05.034. Epub 2014 Jun 2. 56. Serrano ID, Ramu VG, Pinto AR, Freire JM, Tavares I, Heras M, Bardaji ER, Castanho MA. Correlation between membrane translocation and analgesic efficacy in kyotorphin derivatives. Biopolymers. 2015 Jan;104(1):1-10. doi: 10.1002/bip.22580. 57. Raposo D, Morgado C, Pereira-Terra P, Tavares I. Nociceptive spinal cord neurons of laminae I-III exhibit oxidative stress damage during diabetic neuropathy which is prevented by early antioxidant treatment with epigallocatechin-gallate (EGCG). Brain Res Bull. 2015 Jan;110:68-75. doi: 10.1016/j.brainresbull.2014.12.004. Epub 2014 Dec 16. 58. Santos SM, Garcia-Nimo L, Sá Santos S, Tavares I, Cocho JA, Castanho MA. Neuropeptide Kyotorphin (Tyrosyl-Arginine) has Decreased Levels in the Cerebro-Spinal Fluid of Alzheimer's Disease Patients: Potential Diagnostic and Pharmacological Implications. Front Aging Neurosci. 2013 Oct 30;5:68. doi: 10.3389/fnagi.2013.00068. eCollection 2013. 59. Martins I, Carvalho P, de Vries MG, Teixeira-Pinto A, Wilson SP, Westerink B, Tavares IGABA acting on GABAB receptors located in a medullary pain facilitatory area enhances nociceptive behaviors evoked by intraplantar formalin injection. Pain. 2015 Apr 24. [Epub ahead of print] 60. Melo A, Tavares I, Sousa N, Pêgo JM. Can the dopaminergic-related effects of general anesthetics be linked to mechanisms involved in drug abuse and addiction Acta Anaesthesiol Scand. 2015 May 7. doi: 10.1111/aas.12530. [Epub ahead of print] Registo de patentes 1. New L-tyrosyl-L-arginine compounds useful to prevent and/or treat tau-induced cytotoxicity e.g. corticobasal degeneration, frontotemporal dementia with Parkinsonism linked to chromosome 17, Pick's disease and Parkinson's disease Patent Number(s): WO2009123486-A1 ; EP2271332-A1 ; WO2009123486-A8 ; US2011294741-A1 BERNARDO DE SOUSA J M, CASTANHO M A R, CEREJO M I H, CHATERJEE S, COROMINAS M H, DOS SANTOS A M B, MENDES DA SILVA CALADO P, MOREIRA DE OLIVEIRA VIEIRA H, PINHEIRO R F A, PINTO M S C, RIBEIRO M M B, ROCA C F A, RODRIGUES C S R, RODRIGUEZ E B, TAVARES I F, DOS SANTOS A M, RODRIGUES C, PINHEIRO R F, RIBEIRO M M, CASTANHO M A, RODRIGUEZ E, TAVARES I, PINTO M S, CHATTERJEE S, VIEIRA H M M, DE SOUSA J M B, MENDES D S C P, CASTANHO M A R B, PINTO M S C T 2. Use of L-Tyr-L-Arg derivatives for prevention and treatment of pain comprising chronic pain and acute pain Patent Number(s): WO2009123487-A1 ; EP2271659-A1 ; CA2720375-A1 ; US2011082087-A1 RIBEIRO M M B, CASTANHO M A R, ROCA C F A, MOREIRA DE OLIVEIRA VIEIRA H, BERNARDO DE SOUSA J M, CEREJO M I H, MENDES DA SILVA CALADO P, CHATTERJEE S, RODRIGUEZ E B, COROMINAS M H, TAVARES I F, PINTO M S C T, CORREIA A D A, DE SIMAOES MEL M N D S, SIMOES DE MELO M N D, MENDES D S C P, SIMAOES DE MEL M N D S, CASTANHO M A R B