Hélder Cruz
Pain Research
Junior Researcher
Helder Cardoso-Cruz is a researcher at the Institute for Molecular and Cell Biology (IBMC) and Faculty of Medicine of Oporto (FMUP) in Portugal. His research interest is the relationship between pain and cognitive functions, namely the prefrontal-hippocampus dynamics during working-memory processing. His research involves an interdisciplinary approach, combining extracellular multi-channel electrophysiology techniques, behavior performance evaluation, optogenetics brain stimulation, development of analytical tools for the study of neuronal dynamics, and design and implementation of algorithms for decoding neuronal data. He obtained his B.Sc. degree in Applied Biology at the University of Minho (2001, Braga, Portugal). In 2002, he moved to Oporto to joint Vasco Galhardo laboratory where he pursued his graduate studies. The M.Sc. degree was obtained in 2008 at the Faculty of Sciences of the University of Oporto with the thesis The thalamo-cortical oscillations: algorithms to search neuronal patterns. In 2008, he was awarded a FCT fellowship to carry out doctoral studies under supervision of Professor Vasco Galhardo. In 2012, he obtained his doctorate degree (FMUP, Portugal) with the thesis Cortical and subcortical oscillatory dynamics in nociceptive information processing: sensorial and cognitive aspects.
Selected Publications
Cardoso-Cruz H., Paiva P., Monteiro C., Galhardo V.,
Selective optogenetic inhibition of medial prefrontal glutamatergic neurons reverses working memory deficits induced by neuropathic pain. Pain160(4):805-823, 2019. [Journal: Article] [IF: 6,0 (*)]
DOI: 10.1097/j.pain.0000000000001457 SCOPUS: 85063251954. .
Cardoso-Cruz H., Dourado M., Monteiro C., Matos M., Galhardo V.,
Activation of dopaminergic D2/D3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury. Journal of Neuroscience34(17):5861-5873, 2014. [Journal: Article] [CI: 16] [IF: 6,3]
DOI: 10.1523/JNEUROSCI.0021-14.2014 SCOPUS: 84899483174. .
Cardoso-Cruz H., Lima D., Galhardo V.,
Impaired spatial memory performance in a rat model of neuropathic pain is associated with reduced hippocampus-prefrontal cortex connectivity. Journal of Neuroscience33(6):2465-2480, 2013. [Journal: Article] [CI: 58] [IF: 6,7]
DOI: 10.1523/JNEUROSCI.5197-12.2013 SCOPUS: 84873294842. .
Monteiro C., Cardoso-Cruz H., Matos M., Dourado M., Lima D., Galhardo V.,
Increased fronto-hippocampal connectivity in the Prrxl1 knockout mouse model of congenital hypoalgesia. Pain157(9):2045-2056, 2016. [Journal: Article] [CI: 2] [IF: 5,4]
DOI: 10.1097/j.pain.0000000000000611 SCOPUS: 84984605078. .
Cardoso-Cruz H., Sousa M., Vieira J., Lima D., Galhardo V.,
Prefrontal cortex and mediodorsal thalamus reduced connectivity is associated with spatial working memory impairment in rats with inflammatory pain. Pain154(11):2397-2406, 2013. [Journal: Article] [CI: 36] [IF: 5,8]
DOI: 10.1016/j.pain.2013.07.020 SCOPUS: 84886313692. .
Silva A., Cardoso-Cruz H., Silva F., Galhardo V., Antunes L.,
Comparison of anesthetic depth indexes based on thalamocortical local field potentials in rats. Anesthesiology112(2):355-363, 2010. [Journal: Article] [CI: 42] [IF: 5,5]
DOI: 10.1097/ALN.0b013e3181ca3196 SCOPUS: 77449114783. .
Cardoso-Cruz H., Lima D., Galhardo V.,
Instability of spatial encoding by CA1 hippocampal place cells after peripheral nerve injury. European Journal of Neuroscience33(12):2255-2264, 2011. [Journal: Article] [CI: 12] [IF: 3,6]
DOI: 10.1111/j.1460-9568.2011.07721.x SCOPUS: 80955180955. .
Cardoso-Cruz H., Sameshima K., Lima D., Galhardo V.,
Dynamics of circadian thalamocortical flow of information during a peripheral neuropathic pain condition. Frontiers in Integrative Neuroscience5:, 2011. [Journal: Article] [CI: 12]
DOI: 10.3389/fnint.2011.00043 SCOPUS: 82255171062. .
Monteiro C., Cardoso-Cruz H., Galhardo V.,
Animal models of congenital hypoalgesia: Untapped potential for assessing pain-related plasticity. Neuroscience Letters702:51-60, 2019. [Journal: Review] [IF: 2,2 (*)]
DOI: 10.1016/j.neulet.2018.11.045 SCOPUS: 85058222328. .
Cardoso-Cruz H., Dourado M., Monteiro C., Galhardo V.,
Blockade of dopamine D2 receptors disrupts intrahippocampal connectivity and enhances pain-related working memory deficits in neuropathic pain rats. European Journal of Pain (United Kingdom)22(5):1002-1015, 2018. [Journal: Article] [CI: 1] [IF: 3,2]
DOI: 10.1002/ejp.1186 SCOPUS: 85041040353. .
Dourado M., Cardoso-Cruz H., Monteiro C., Galhardo V.,
Effect of motor impairment on analgesic efficacy of dopamine D2/3 receptors in a rat model of neuropathy. Journal of Experimental Neuroscience2016(10):51-57, 2016. [Journal: Article] [CI: 2]
DOI: 10.4137/JEn.s36492 SCOPUS: 85015234903. .
Selective optogenetic inhibition of medial prefrontal glutamatergic neurons reverses working memory deficits induced by neuropathic pain. Pain160(4):805-823, 2019. [Journal: Article] [IF: 6,0 (*)]
DOI: 10.1097/j.pain.0000000000001457 SCOPUS: 85063251954. .
Cardoso-Cruz H., Dourado M., Monteiro C., Matos M., Galhardo V.,
Activation of dopaminergic D2/D3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury. Journal of Neuroscience34(17):5861-5873, 2014. [Journal: Article] [CI: 16] [IF: 6,3]
DOI: 10.1523/JNEUROSCI.0021-14.2014 SCOPUS: 84899483174. .
Cardoso-Cruz H., Lima D., Galhardo V.,
Impaired spatial memory performance in a rat model of neuropathic pain is associated with reduced hippocampus-prefrontal cortex connectivity. Journal of Neuroscience33(6):2465-2480, 2013. [Journal: Article] [CI: 58] [IF: 6,7]
DOI: 10.1523/JNEUROSCI.5197-12.2013 SCOPUS: 84873294842. .
Monteiro C., Cardoso-Cruz H., Matos M., Dourado M., Lima D., Galhardo V.,
Increased fronto-hippocampal connectivity in the Prrxl1 knockout mouse model of congenital hypoalgesia. Pain157(9):2045-2056, 2016. [Journal: Article] [CI: 2] [IF: 5,4]
DOI: 10.1097/j.pain.0000000000000611 SCOPUS: 84984605078. .
Cardoso-Cruz H., Sousa M., Vieira J., Lima D., Galhardo V.,
Prefrontal cortex and mediodorsal thalamus reduced connectivity is associated with spatial working memory impairment in rats with inflammatory pain. Pain154(11):2397-2406, 2013. [Journal: Article] [CI: 36] [IF: 5,8]
DOI: 10.1016/j.pain.2013.07.020 SCOPUS: 84886313692. .
Silva A., Cardoso-Cruz H., Silva F., Galhardo V., Antunes L.,
Comparison of anesthetic depth indexes based on thalamocortical local field potentials in rats. Anesthesiology112(2):355-363, 2010. [Journal: Article] [CI: 42] [IF: 5,5]
DOI: 10.1097/ALN.0b013e3181ca3196 SCOPUS: 77449114783. .
Cardoso-Cruz H., Lima D., Galhardo V.,
Instability of spatial encoding by CA1 hippocampal place cells after peripheral nerve injury. European Journal of Neuroscience33(12):2255-2264, 2011. [Journal: Article] [CI: 12] [IF: 3,6]
DOI: 10.1111/j.1460-9568.2011.07721.x SCOPUS: 80955180955. .
Cardoso-Cruz H., Sameshima K., Lima D., Galhardo V.,
Dynamics of circadian thalamocortical flow of information during a peripheral neuropathic pain condition. Frontiers in Integrative Neuroscience5:, 2011. [Journal: Article] [CI: 12]
DOI: 10.3389/fnint.2011.00043 SCOPUS: 82255171062. .
Monteiro C., Cardoso-Cruz H., Galhardo V.,
Animal models of congenital hypoalgesia: Untapped potential for assessing pain-related plasticity. Neuroscience Letters702:51-60, 2019. [Journal: Review] [IF: 2,2 (*)]
DOI: 10.1016/j.neulet.2018.11.045 SCOPUS: 85058222328. .
Cardoso-Cruz H., Dourado M., Monteiro C., Galhardo V.,
Blockade of dopamine D2 receptors disrupts intrahippocampal connectivity and enhances pain-related working memory deficits in neuropathic pain rats. European Journal of Pain (United Kingdom)22(5):1002-1015, 2018. [Journal: Article] [CI: 1] [IF: 3,2]
DOI: 10.1002/ejp.1186 SCOPUS: 85041040353. .
Dourado M., Cardoso-Cruz H., Monteiro C., Galhardo V.,
Effect of motor impairment on analgesic efficacy of dopamine D2/3 receptors in a rat model of neuropathy. Journal of Experimental Neuroscience2016(10):51-57, 2016. [Journal: Article] [CI: 2]
DOI: 10.4137/JEn.s36492 SCOPUS: 85015234903. .