Where Ideas grow
Salomé Pinho
Group leader
Salomé Pinho received her D.V.M. from the University of Porto in 2004 and developed her PhD research at the Institute of Molecular Pathology and Immunology of Univ. Porto (IPATIMUP) and at Boston Medical School, MA, USA from 2006 to 2009. She performed her postdoctoral work at IPATIMUP in the glycobiology and disease field. At present, she is Researcher (PI) at IPATIMUP/i3S and affiliated Professor at Faculty of Medicine at University of Porto. Her research activity is focused on the understanding of the role of post-translational modifications by glycosylation in the regulation of key proteins´ functions involved in cancer and in chronic inflammatory conditions, envisioning potential clinical applications. She is author of several publications in international peer-reviewed journals (as first and senior author) including Nature Reviews Cancer, Oncogene and Human Molecular Genetics. She supervises a research team composed by Post-Docs, PhD students, Master students and young researchers. She is the Principal Investigator of several national/international funded projects in the field of cancer and inflammatory diseases. She received the Young Investigator Award from the European Association for Cancer Research and is inventor of 2 patents.

Selected Publications

Pinho S.S., Reis C.A.,
Glycosylation in cancer: Mechanisms and clinical implications. Nature Reviews Cancer15(9):540-555, 2015. [Journal: Review] [CI: 807] [IF: 34,2]
DOI: 10.1038/nrc3982 SCOPUS: 84940449986. .

Carvalho S., Catarino T.A., Dias A.M., Kato M., Almeida A., Hessling B., Figueiredo J., Gartner F., Sanches J.M., Ruppert T., Miyoshi E., Pierce M., Carneiro F., Kolarich D., Seruca R., Yamaguchi Y., Taniguchi N., Reis C.A., Pinho S.S.,
Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer. Oncogene35(13):1619-1631, 2016. [Journal: Article] [CI: 52] [IF: 7,5]
DOI: 10.1038/onc.2015.225 SCOPUS: 84937605601. .

Pinho S.S., Carvalho S., Marcos-Pinto R., Magalhães A., Oliveira C., Gu J., Dinis-Ribeiro M., Carneiro F., Seruca R., Reis C.A.,
Gastric cancer: Adding glycosylation to the equation. Trends in Molecular Medicine19(11):664-676, 2013. [Journal: Review] [CI: 65] [IF: 10,1]
DOI: 10.1016/j.molmed.2013.07.003 SCOPUS: 84886951831. .

Carvalho S., Reis C.A., Pinho S.S.,
Cadherins Glycans in Cancer: Sweet Players in a Bitter Process. Trends in Cancer2(9):519-531, 2016. [Journal: Review] [CI: 16]
DOI: 10.1016/j.trecan.2016.08.003 SCOPUS: 84989821862. .

Dias A.M., Dourado J., Lago P., Cabral J., Marcos-Pinto R., Salgueiro P., Almeida C.R., Carvalho S., Fonseca S., Lima M., Vilanova M., Dinis-Ribeiro M., Reis C.A., Pinho S.S.,
Dysregulation of T cell receptor N-glycosylation: A molecular mechanism involved in ulcerative colitis. Human Molecular Genetics23(9):2416-2427, 2014. [Journal: Article] [CI: 19] [IF: 6,4]
DOI: 10.1093/hmg/ddt632 SCOPUS: 84897565140. .

Dias A.M., Almeida C.R., Reis C.A., Pinho S.S.,
Studying T cells N -glycosylation by imaging flow cytometry. Methods in Molecular Biology1389:167-176, 2016. [Book Series: Article] [CI: 4]
DOI: 10.1007/978-1-4939-3302-0_11 SCOPUS: 84990063211. .

Carvalho S., Oliveira T., Bartels M.F., Miyoshi E., Pierce M., Taniguchi N., Carneiro F., Seruca R., Reis C.A., Strahl S., Pinho S.S.,
O-mannosylation and N-glycosylation: Two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer. Oncotarget7(40):65231-65246, 2016. [Journal: Article] [CI: 13] [IF: 5,2]
DOI: 10.18632/oncotarget.11245 SCOPUS: 84993660248. .

Pinho S.S., Reis C.A., Paredes J., Magalhães A.M., Ferreira A.C., Figueiredo J., Xiaogang W., Carneiro F., Gärtner F.F., Seruca R.,
The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin. Human Molecular Genetics18(14):2599-2608, 2009. [Journal: Article] [CI: 74] [IF: 7,4]
DOI: 10.1093/hmg/ddp194 SCOPUS: 67649859659. .

Pinho S.S., Seruca R., Gärtner F., Yamaguchi Y., Gu J., Taniguchi N., Reis C.A.,
Modulation of E-cadherin function and dysfunction by N-glycosylation. Cellular and Molecular Life Sciences68(6):1011-1020, 2011. [Journal: Review] [CI: 98] [IF: 6,6]
DOI: 10.1007/s00018-010-0595-0 SCOPUS: 79953721653. .

Paredes J., Figueiredo J., Albergaria A., Oliveira P., Carvalho J., Ribeiro A.S., Caldeira J., Costa A.M., Simões-Correia J., Oliveira M.J., Pinheiro H., Pinho S.S., Mateus R., Reis C.A., Leite M., Fernandes M.S., Schmitt F., Carneiro F., Figueiredo C., Oliveira C., Seruca R.,
Epithelial E- and P-cadherins: Role and clinical significance in cancer. Biochimica et Biophysica Acta - Reviews on Cancer1826(2):297-311, 2012. [Journal: Review] [CI: 129] [IF: 9]
DOI: 10.1016/j.bbcan.2012.05.002 SCOPUS: 84861800037. .

Pereira C.C., Durães C., Coelho R., Grácio D., Silva M., Peixoto A., Lago P., Pereira M., Catarino T., Pinho S., Teixeira J.P., Macedo G., Annese V., Magro F.,
Association between polymorphisms in antioxidant genes and inflammatory bowel disease. PLoS ONE12(1):, 2017. [Journal: Article] [CI: 9] [IF: 2,8]
DOI: 10.1371/journal.pone.0169102 SCOPUS: 85008394516. .