People
Hugo Osório
Proteomics
Assistant Researcher
Proteomics
Assistant Researcher
Hugo Osório is team coordinator of the Proteomics Scientific Platform at i3S and a researcher at the Glycobiology in Cancer group. He is also an Affiliated Professor at the Faculty of Medicine of the University of Porto. He graduated in Biochemistry at University of Porto in 1999 and finished his PhD in Biomedical Sciences in 2004 at ICBAS-UP. He is specialized in proteomics and mass spectrometry applied to health and life sciences. His major research activity is focused in the search for novel protein biomarkers with diagnostic application in cancer with an emphasis in protein post-translational modifications namely glycosylation. Hugo Osorio has 54 publications in international peer-reviewed journals and three book chapters. His research work has around 1000 citations and an h-index of 15 (Scopus).
Selected Publications
Zhang H., Freitas D., Kim H., Fabijanic K., Li Z., Chen H., Mark M., Molina H., Martin A., Bojmar L., Fang J., Rampersaud S., Hoshino A., Matei I., Kenific C., Nakajima M., Mutvei A., Sansone P., Buehring W., Wang H., Jimenez J., Cohen-Gould L., Paknejad N., Brendel M., Manova-Todorova K., Magalhães A., Ferreira J., Osório H., Silva A., Massey A., Cubillos-Ruiz J., Galletti G., Giannakakou P., Cuervo A., Blenis J., Schwartz R., Brady M., Peinado H., Bromberg J., Matsui H., Reis C., Lyden D.,
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nature Cell Biology20(3):332-343, 2018. [Journal: Article] [CI: 49] [IF: 19,1 (*)]
DOI: 10.1038/s41556-018-0040-4 SCOPUS: 85042193942. .
Korsak B., Almeida G., Rocha S., Pereira C., Mendes N., Osório H., Pereira P., Rodrigues J., Schneider R., Sarmento B., Tomé J., Oliveira C.,
Porphyrin modified trastuzumab improves efficacy of HER2 targeted photodynamic therapy of gastric cancer. International Journal of Cancer141(7):1478-1489, 2017. [Journal: Article] [CI: 2] [IF: 7,4]
DOI: 10.1002/ijc.30844 SCOPUS: 85022335625. .
Osório H., Reis C.,
Mass spectrometry methods for studying glycosylation in cancer. Methods in Molecular Biology1007:301-316, 2013. [Book Series: Article] [CI: 14]
DOI: 10.1007/978-1-62703-392-3-13 SCOPUS: 84883156078. .
Catera M., Borelli V., Malagolini N., Chiricolo M., Venturi G., Reis C., Osorio H., Abruzzo P., Capri M., Monti D., Ostan R., Franceschi C., Dall'Olio F.,
Identification of novel plasma glycosylation-associated markers of aging. Oncotarget7(7):7455-7468, 2016. [Journal: Article] [CI: 10] [IF: 5,2]
DOI: 10.18632/oncotarget.7059 SCOPUS: 84958817824. .
Reis C., Osorio H., Silva L., Gomes C., David L.,
Alterations in glycosylation as biomarkers for cancer detection. Journal of Clinical Pathology63(4):322-329, 2010. [Journal: Review] [CI: 248] [IF: 2,5]
DOI: 10.1136/jcp.2009.071035 SCOPUS: 77950410995. .
Barbosa A., Osório H., Sims K., Almeida T., Alves M., Bielawski J., Amorim M., Moradas-Ferreira P., Hannun Y., Costa V.,
Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. Molecular Microbiology81(2):515-527, 2011. [Journal: Article] [CI: 31] [IF: 5]
DOI: 10.1111/j.1365-2958.2011.07714.x SCOPUS: 79960193275. .
Almeida M., Mesquita F., Cruz R., Osório H., Custódio R., Brito C., Vingadassalom D., Martins M., Leong J., Holden D., Cabanes D., Sousa S.,
Src-dependent tyrosine phosphorylation of non-muscle myosin heavy chain-IIA restricts Listeria monocytogenes cellular infection. Journal of Biological Chemistry290(13):8383-8395, 2015. [Journal: Article] [CI: 5] [IF: 4,3]
DOI: 10.1074/jbc.M114.591313 SCOPUS: 84925760833. .
Maia L., Magalhães R., Freitas J., Taipa R., Pires M., Osório H., Dias D., Pessegueiro H., Correia M., Coelho T.,
CNS involvement in V30M transthyretin amyloidosis: Clinical, neuropathological and biochemical findings. Journal of Neurology Neurosurgery and Psychiatry86(2):159-167, 2015. [Journal: Article] [CI: 44] [IF: 6,4]
DOI: 10.1136/jnnp-2014-308107 SCOPUS: 84921404034. .
Branquinho R., Sousa C., Lopes J., Pintado M., Peixe L., Osório H.,
Differentiation of Bacillus pumilus and Bacillus safensis Using MALDI-TOF-MS. PLoS ONE9(10):, 2014. [Journal: Article] [CI: 19] [IF: 3,2]
DOI: 10.1371/journal.pone.0110127 SCOPUS: 84907978977. .
Gomes C., Almeida A., Ferreira J., Silva L., Santos-Sousa H., Pinto-De-Sousa J., Santos L., Amado F., Schwientek T., Levery S., Mandel U., Clausen H., David L., Reis C., Osório H.,
Glycoproteomic analysis of serum from patients with gastric precancerous lesions. Journal of Proteome Research12(3):1454-1466, 2013. [Journal: Article] [CI: 41] [IF: 5]
DOI: 10.1021/pr301112x SCOPUS: 84874635340. .
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nature Cell Biology20(3):332-343, 2018. [Journal: Article] [CI: 49] [IF: 19,1 (*)]
DOI: 10.1038/s41556-018-0040-4 SCOPUS: 85042193942. .
Korsak B., Almeida G., Rocha S., Pereira C., Mendes N., Osório H., Pereira P., Rodrigues J., Schneider R., Sarmento B., Tomé J., Oliveira C.,
Porphyrin modified trastuzumab improves efficacy of HER2 targeted photodynamic therapy of gastric cancer. International Journal of Cancer141(7):1478-1489, 2017. [Journal: Article] [CI: 2] [IF: 7,4]
DOI: 10.1002/ijc.30844 SCOPUS: 85022335625. .
Osório H., Reis C.,
Mass spectrometry methods for studying glycosylation in cancer. Methods in Molecular Biology1007:301-316, 2013. [Book Series: Article] [CI: 14]
DOI: 10.1007/978-1-62703-392-3-13 SCOPUS: 84883156078. .
Catera M., Borelli V., Malagolini N., Chiricolo M., Venturi G., Reis C., Osorio H., Abruzzo P., Capri M., Monti D., Ostan R., Franceschi C., Dall'Olio F.,
Identification of novel plasma glycosylation-associated markers of aging. Oncotarget7(7):7455-7468, 2016. [Journal: Article] [CI: 10] [IF: 5,2]
DOI: 10.18632/oncotarget.7059 SCOPUS: 84958817824. .
Reis C., Osorio H., Silva L., Gomes C., David L.,
Alterations in glycosylation as biomarkers for cancer detection. Journal of Clinical Pathology63(4):322-329, 2010. [Journal: Review] [CI: 248] [IF: 2,5]
DOI: 10.1136/jcp.2009.071035 SCOPUS: 77950410995. .
Barbosa A., Osório H., Sims K., Almeida T., Alves M., Bielawski J., Amorim M., Moradas-Ferreira P., Hannun Y., Costa V.,
Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. Molecular Microbiology81(2):515-527, 2011. [Journal: Article] [CI: 31] [IF: 5]
DOI: 10.1111/j.1365-2958.2011.07714.x SCOPUS: 79960193275. .
Almeida M., Mesquita F., Cruz R., Osório H., Custódio R., Brito C., Vingadassalom D., Martins M., Leong J., Holden D., Cabanes D., Sousa S.,
Src-dependent tyrosine phosphorylation of non-muscle myosin heavy chain-IIA restricts Listeria monocytogenes cellular infection. Journal of Biological Chemistry290(13):8383-8395, 2015. [Journal: Article] [CI: 5] [IF: 4,3]
DOI: 10.1074/jbc.M114.591313 SCOPUS: 84925760833. .
Maia L., Magalhães R., Freitas J., Taipa R., Pires M., Osório H., Dias D., Pessegueiro H., Correia M., Coelho T.,
CNS involvement in V30M transthyretin amyloidosis: Clinical, neuropathological and biochemical findings. Journal of Neurology Neurosurgery and Psychiatry86(2):159-167, 2015. [Journal: Article] [CI: 44] [IF: 6,4]
DOI: 10.1136/jnnp-2014-308107 SCOPUS: 84921404034. .
Branquinho R., Sousa C., Lopes J., Pintado M., Peixe L., Osório H.,
Differentiation of Bacillus pumilus and Bacillus safensis Using MALDI-TOF-MS. PLoS ONE9(10):, 2014. [Journal: Article] [CI: 19] [IF: 3,2]
DOI: 10.1371/journal.pone.0110127 SCOPUS: 84907978977. .
Gomes C., Almeida A., Ferreira J., Silva L., Santos-Sousa H., Pinto-De-Sousa J., Santos L., Amado F., Schwientek T., Levery S., Mandel U., Clausen H., David L., Reis C., Osório H.,
Glycoproteomic analysis of serum from patients with gastric precancerous lesions. Journal of Proteome Research12(3):1454-1466, 2013. [Journal: Article] [CI: 41] [IF: 5]
DOI: 10.1021/pr301112x SCOPUS: 84874635340. .