Where Ideas grow
Alexandra Moreira
Principal Researcher
Alexandra Moreira holds a D. Phil. in Molecular Biology, University of Oxford, UK and a degree in Biochemistry, Faculty of Sciences, University of Lisbon. She currently holds a Principal Investigator position at the University of Porto and is the leader of the group Gene Regulation. Together with her research activities, A. Moreira lectures at ICBAS, teaches at several MSc and PhD courses and is a member of the Scientific Board of the Molecular and Cell Biology PhD Program, University Porto. A. Moreira has served as a member of the IBMC Executive Committee in the past. The objective of her research group is to understand the molecular mechanisms involved in the integration of RNAPII transcription and alternative pre-mRNA processing, with a focus on those events that are physiologically relevant in health and disease, using state-of-the-art molecular biology methodologies.
Selected Publications
Liu X., Freitas J., Zheng D., Oliveira M., Hoque M., Martins T., Henriques T., Tian B., Moreira A.,
Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster. RNA23(12):1807-1816, 2017. [Journal: Article] [CI: 7] [IF: 4,5]
DOI: 10.1261/rna.062661.117 SCOPUS: 85034084061. .

Rodrigues P., Ribeiro A., Perrod C., Landry J., Araújo L., Pereira-Castro I., Benes V., Moreira A., Xavier-Ferreira H., Meireles C., Alves N.,
Thymic epithelial cells require p53 to support their long-term function in thymopoiesis in mice. Blood130(4):478-488, 2017. [Journal: Article] [CI: 3] [IF: 15,1]
DOI: 10.1182/blood-2016-12-758961 SCOPUS: 85026293874. .

Braz S., Cruz A., Lobo A., Bravo J., Moreira-Ribeiro J., Pereira-Castro I., Freitas J., Relvas J., Summavielle T., Moreira A.,
Expression of Rac1 alternative 3' UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms1860(6):685-694, 2017. [Journal: Article] [CI: 1] [IF: 5,2]
DOI: 10.1016/j.bbagrm.2017.03.002 SCOPUS: 85018940086. .

Domingues R., Lago-Baldaia I., Pereira-Castro I., Fachini J., Oliveira L., Drpic D., Lopes N., Henriques T., Neilson J., Carmo A., Moreira A.,
CD5 expression is regulated during human T-cell activation by alternative polyadenylation, PTBP1, and miR-204. European Journal of Immunology46(6):1490-1503, 2016. [Journal: Article] [CI: 3] [IF: 4,2]
DOI: 10.1002/eji.201545663 SCOPUS: 84973661630. .

Curinha A., Braz S., Pereira-Castro I., Cruz A., Moreira A.,
Implications of polyadenylation in health and disease. Nucleus5(6):508-519, 2014. [Journal: Article] [CI: 39] [IF: 3]
DOI: 10.4161/nucl.36360 SCOPUS: 84921902866. .

Da Glória V., De Araújo M., Santos A., Leal R., De Almeida S., Carmo A., Moreira A.,
T cell activation regulates CD6 alternative splicing by transcription dynamics and SRSF1. Journal of Immunology193(1):391-399, 2014. [Journal: Article] [CI: 13] [IF: 4,9]
DOI: 10.4049/jimmunol.1400038 SCOPUS: 84903626125. .

Pinto P., Henriques T., Freitas M., Martins T., Domingues R., Wyrzykowska P., Coelho P., Carmo A., Sunkel C., Proudfoot N., Moreira A.,
RNA polymerase II kinetics in polo polyadenylation signal selection. EMBO Journal30(12):2431-2444, 2011. [Journal: Article] [CI: 69] [IF: 9,2]
DOI: 10.1038/emboj.2011.156 SCOPUS: 79958859723. .

Castro M., Oliveira M., Nunes R., Fabre S., Barbosa R., Peixoto A., Brown M., Parnes J., Bismuth G., Moreira A., Rocha B., Carmo A.,
Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse. Journal of Immunology178(7):4351-4361, 2007. [Journal: Article] [CI: 35] [IF: 6,1]
DOI: 10.4049/jimmunol.178.7.4351 SCOPUS: 33947649690. .

Castelo-Branco P., Furger A., Wollerton M., Smith C., Moreira A., Proudfoot N.,
Polypyrimidine tract binding protein modulates efficiency of polyadenylation. Molecular and Cellular Biology24(10):4174-4183, 2004. [Journal: Article] [CI: 124] [IF: 7,8]
DOI: 10.1128/MCB.24.10.4174-4183.2004 SCOPUS: 2942629589. .

Moreira A., Takagaki Y., Brackenridge S., Wollerton M., Manley J., Proudfoot N.,
The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms. Genes and Development12(16):2522-2534, 1998. [Journal: Article] [CI: 125] [IF: 19,1]
DOI: 10.1101/gad.12.16.2522 SCOPUS: 0032529163. .

Llamazares S., Moreira A., Tavares A., Girdham C., Spruce B., Gonzalez C., Karess R., Glover D., Sunkel C.,
Polo encodes a protein kinase homolog required for mitosis in Drosophila. Genes and Development5(12):2153-2165, 1991. [Journal: Article] [CI: 266]
DOI: 10.1101/gad.5.12a.2153 SCOPUS: 0025840258. .