People
Florence Janody
Cytoskeletal Regulation & Cancer
Principal Researcher

Florence Janody performed her Ph.D. in Cell Biology, Structural Biology and Microbiology at the Developmental Biology Institute of Marseille Luminy (IBDML) in the laboratory of Dr. Nathalie Dostatni before joining the laboratory of Dr. Jessica Treisman for a Postdoctoral training at Skirball Institute in New York (USA) in 2000. During these trainings, her main interest has been to understand how signal transduction cascades regulate gene expression. In a mosaic genetic screen for novel genes involved in signalling activity, she identified loss of function mutation for genes encoding Actin Binding Proteins (ABP). She established her independency in 2006 at Instituto Gulbenkian de Ciência (IGC) in Portugal, with the goal of demonstrating a role of the actin microfilament system in controlling the activity of signal transduction pathways involved in cell proliferation and survival. Her lab has demonstrated a reciprocal dialogue between the actin cytoskeleton and cancer pathways underlying benign tumour development. She moved her lab in January 2018 to Instituto de Patologia e Imunologia Molecular da Universidade do Porto (Ipatimup)/ Instituto de Investigação e Inovação em Saúde (i3S) with the goal of deciphering the molecular and cellular mechanisms by which cytoskeletal deregulation underlies benign tumour development and their progression into invasive cancer using the fruit fly Drosophila melanogaster; inducible human cell lines, tumour samples and computational modelling.

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Selected Publications
Janody F.,
The Big Bang of tissue growth: Apical cell constriction turns into tissue expansion. Journal of Cell Biology217(3):807-808, 2018. [Journal: Note] [IF: 8,8 (*)]
DOI: 10.1083/jcb.201801076 SCOPUS: 85042848294. .

Tavares S., Vieira A., Taubenberger A., Araújo M., Martins N., Brás-Pereira C., Polónia A., Herbig M., Barreto C., Otto O., Cardoso J., Pereira-Leal J., Guck J., Paredes J., Janody F.,
Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells. Nature Communications8:, 2017. [Journal: Article] [CI: 14] [IF: 12,4]
DOI: 10.1038/ncomms15237 SCOPUS: 85019618841. .

Brás-Pereira C., Potier D., Jacobs J., Aerts S., Casares F., Janody F.,
dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis. PLoS Genetics12(7):, 2016. [Journal: Article] [CI: 4] [IF: 6,1]
DOI: 10.1371/journal.pgen.1006204 SCOPUS: 84982854129. .

Caldeira J., Figueiredo J., Brás-Pereira C., Carneiro P., Moreira A., Pinto M., Relvas J., Carneiro F., Barbosa M., Casares F., Janody F., Seruca R.,
E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade. Human Molecular Genetics24(20):5891-5900, 2015. [Journal: Article] [CI: 10] [IF: 6]
DOI: 10.1093/hmg/ddv312 SCOPUS: 84943762566. .

Brás-Pereira C., Casares F., Janody F.,
The retinal determination gene dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex. Development142(8):1470-1479, 2015. [Journal: Article] [CI: 10] [IF: 6,1]
DOI: 10.1242/dev.113340 SCOPUS: 84926380808. .

Gaspar P., Holder M., Aerne B., Janody F., Tapon N.,
Zyxin antagonizes the FERM protein expanded to couple f-actin and yorkie-dependent organ growth. Current Biology25(6):679-689, 2015. [Journal: Article] [CI: 25] [IF: 9]
DOI: 10.1016/j.cub.2015.01.010 SCOPUS: 84926322744. .

Fernández B., Jezowska B., Janody F.,
Drosophila actin-Capping Protein limits JNK activation by the src proto-oncogene. Oncogene33(16):2027-2039, 2014. [Journal: Article] [CI: 23] [IF: 8,5]
DOI: 10.1038/onc.2013.155 SCOPUS: 84899417132. .

Amândio A., Gaspar P., Whited J., Janody F.,
Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels. PLoS ONE9(5):, 2014. [Journal: Article] [CI: 6] [IF: 3,2]
DOI: 10.1371/journal.pone.0096326 SCOPUS: 84900398117. .

Fernández B., Gaspar P., Brás-Pereira C., Jezowska B., Rebelo S., Janody F.,
Actin-capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Development138(11):2337-2346, 2011. [Journal: Article] [CI: 179] [IF: 6,6]
DOI: 10.1242/dev.063545 SCOPUS: 79956327002. .

Jezowska B., Fernández B., Amândio A., Duarte P., Mendes C., Brás-Pereira C., Janody F.,
A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis. Developmental Biology360(1):143-159, 2011. [Journal: Article] [CI: 7] [IF: 4,1]
DOI: 10.1016/j.ydbio.2011.09.016 SCOPUS: 80755133315. .