Where Ideas grow
Ana Paula Pêgo
Principal Researcher

Ana Paula Pêgo got her Ph.D. in Polymer Chemistry and Biomaterials from the University of Twente, the Netherlands, in 2002. In 2003 she became a researcher at INEB where she is a Principal Investigator since 2012.

By using nanomedicine strategies her group – the nanoBiomaterials for Targeted Therapies (nBTT) Group - aims at providing in situ and in a targeted manner the required signals to promote nervous tissue regeneration. The research on new biomaterials for application in neurosciences includes the development of new polymers for the design of alternative vectors to viruses for efficient nucleic acid delivery and preparation of nerve grafts for spinal cord injury treatment. Societal and ethical issues that concern Regenerative Medicine and NanoMedicine are also a topic in which Ana Pêgo is involved.

She has been appointed the Scientific Director of the Bioimaging Centre for Biomaterials and Regenerative Therapies of INEB and she is an Invited Associate Professor at the Instituto de Ciências Biomédicas Abel Salazar (ICBAS) and at the Faculty of Engineering (FEUP) of the University of Porto.

Selected Publications
Lopes C., Gonçalves N., Gomes C., Saraiva M., Pêgo A.,
BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury. Biomaterials121:83-96, 2017. [Journal: Article] [CI: 11] [IF: 8,8]
DOI: 10.1016/j.biomaterials.2016.12.025 SCOPUS: 85008958194. .

Gomes C., Lopes C., Leitner M., Ebner A., Hinterdorfer P., Pêgo A.,
Atomic Force Microscopy as a Tool to Assess the Specificity of Targeted Nanoparticles in Biological Models of High Complexity. Advanced Healthcare Materials6(21):, 2017. [Journal: Article] [CI: 2] [IF: 5,6]
DOI: 10.1002/adhm.201700597 SCOPUS: 85026363665. .

Leiro V., Garcia J., Moreno P., Spencer A., Fernandez-Villamarin M., Riguera R., Fernandez-Megia E., Paula Pêgo A.,
Biodegradable PEG-dendritic block copolymers: Synthesis and biofunctionality assessment as vectors of siRNA. Journal of Materials Chemistry B5(25):4901-4917, 2017. [Journal: Article] [CI: 7] [IF: 4,8]
DOI: 10.1039/c7tb00279c SCOPUS: 85021637380. .

Gomes C., Varela-Moreira A., Leiro V., Lopes C., Moreno P., Gomez-Lazaro M., Pêgo A.,
A high-throughput bioimaging study to assess the impact of chitosan-based nanoparticle degradation on DNA delivery performance. Acta Biomaterialia46:129-140, 2016. [Journal: Article] [CI: 5] [IF: 6,3]
DOI: 10.1016/j.actbio.2016.09.037 SCOPUS: 84992170399. .

Silva J., Bento A., Barros D., Laundos T., Sousa S., Quelhas P., Sousa M., Pêgo A., Amaral I.,
Fibrin functionalization with synthetic adhesive ligands interacting with a6ß1 integrin receptor enhance neurite outgrowth of embryonic stem cell-derived neural stem/progenitors. Acta Biomaterialia59:243-256, 2017. [Journal: Article] [CI: 2] [IF: 6,4]
DOI: 10.1016/j.actbio.2017.07.013 SCOPUS: 85023776762. .

Rocha D., Ferraz-Nogueira J., Barrias C., Relvas J., Pêgo A.,
Extracellular environment contribution to astrogliosis—lessons learned from a tissue engineered 3D model of the glial scar. Frontiers in Cellular Neuroscience9(SEPTEMBER):, 2015. [Journal: Article] [CI: 6] [IF: 4,6]
DOI: 10.3389/fncel.2015.00377 SCOPUS: 84944455274. .

Rocha D., Brites P., Fonseca C., Pêgo A.,
Poly(trimethylene carbonate-co-e-caprolactone) promotes axonal growth. PLoS ONE9(2):, 2014. [Journal: Article] [CI: 14] [IF: 3,2]
DOI: 10.1371/journal.pone.0088593 SCOPUS: 84896121626. .

Lopes C., Gomes C., Neto E., Sampaio P., Aguiar P., Pêgo A.,
Microfluidic-based platform to mimic the in vivo peripheral administration of neurotropic nanoparticles. Nanomedicine11(24):3205-3221, 2016. [Journal: Article] [CI: 5] [IF: 4,7]
DOI: 10.2217/nnm-2016-0247 SCOPUS: 84998705753. .

Moreno P., Santos J., Gomes C., Varela-Moreira A., Costa A., Leiro V., Mansur H., Peîgo A.,
Delivery of Splice Switching Oligonucleotides by Amphiphilic Chitosan-Based Nanoparticles. Molecular Pharmaceutics13(2):344-356, 2016. [Journal: Article] [CI: 10] [IF: 4,4]
DOI: 10.1021/acs.molpharmaceut.5b00538 SCOPUS: 84957309922. .

Leiro V., Duque Santos S., Lopes C., Paula Pêgo A.,
Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine. Advanced Functional Materials28(12):, 2018. [Journal: Article] [CI: 5] [IF: 13,3 (*)]
DOI: 10.1002/adfm.201700313 SCOPUS: 85019665316. .