Carla Lopes
Glial Cell Biology
Junior Researcher
C. Lopes has an extensive experience in the field of Drosophila developmental biology, genetics and cell cycle regulation. C. Lopes graduated in Biology (Microbiology and Genetics, University of Lisbon) and obtained her PhD from the University of Porto (ICBAS, 2005), under the supervision of Professor Claudio Sunkel. Her research addressed the molecular mechanisms underlying chromosome misegregation during cell division, using Drosophila as a model. C. Lopes developed her post-doctoral work under the supervison of Fernando Casares at the Andalusian Centre for Developmental Biology. She studied how proliferation and patterning are coupled during development. Since June 2013 C. Lopes is head of the Neurodevelopment and Degeneration Group at IBMC. The group studies the function of cell cycle regulators in nervous system development and homeostasis, using Drosophila as a model system and gene-function and biochemical approaches to attain biological knowledge on neurodevelopment associated processes and diseases.
Selected Publications
Vollmer J., Fried P., Sánchez-Aragón M., Lopes C., Casares F., Iber D.,
A quantitative analysis of growth control in the Drosophila eye disc. Development143(9):1482-1490, 2016. [Journal: Article] [CI: 9] [IF: 5,8]
DOI: 10.1242/dev.129775 SCOPUS: 84964847429. .
Piñeiro C., Lopes C., Casares F.,
A conserved transcriptional network regulates lamina development in the Drosophila visual system. Development141(14):2838-2847, 2014. [Journal: Article] [CI: 9] [IF: 6,5]
DOI: 10.1242/dev.108670 SCOPUS: 84903977990. .
Royo J., Maeso I., Irimia M., Gao F., Peter I., Lopes C., D'Aniello S., Casares F., Davidson E., Garcia-Fernández J., Gómez-Skarmeta J.,
Transphyletic conservation of developmental regulatory state in animal evolution. Proceedings of the National Academy of Sciences of the United States of America108(34):14186-14191, 2011. [Journal: Article] [CI: 53] [IF: 9,7]
DOI: 10.1073/pnas.1109037108 SCOPUS: 80052152362. .
Lopes C., Casares F.,
Hth maintains the pool of eye progenitors and its downregulation by Dpp and Hh couples retinal fate acquisition with cell cycle exit. Developmental Biology339(1):78-88, 2010. [Journal: Article] [CI: 42] [IF: 4,1]
DOI: 10.1016/j.ydbio.2009.12.020 SCOPUS: 77649188502. .
Maia A., Lopes C., Sunkel C.,
BubR1 and CENP-E have antagonistic effects upon the stability of microtubule-kinetochore attachments in Drosophila S2 cell mitosis. Cell Cycle6(11):1367-1378, 2007. [Journal: Article] [CI: 25] [IF: 3,3]
DOI: 10.4161/cc.6.11.4271 SCOPUS: 34547702755. .
Lopes C., Sampaio P., Williams B., Goldberg M., Sunkel C.,
The Drosophila Bub3 protein is required for the mitotic checkpoint and for normal accumulation of cyclins during G2 and early stages of mitosis. Journal of Cell Science118(1):187-198, 2005. [Journal: Article] [CI: 32] [IF: 6,5]
DOI: 10.1242/jcs.01602 SCOPUS: 14044275563. .
Logarinho E., Bousbaa H., Dias J., Lopes C., Amorim I., Antunes-Martins A., Sunkel C.,
Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cells. Journal of Cell Science117(9):1757-1771, 2004. [Journal: Article] [CI: 85] [IF: 6,9]
DOI: 10.1242/jcs.01033 SCOPUS: 2342429609. .
Lopes C., Sunkel C.,
The spindle checkpoint: From normal cell division to tumorigenesis. Archives of Medical Research34(3):155-165, 2003. [Journal: Review] [CI: 15] [IF: 1,3]
DOI: 10.1016/S0188-4409(03)00024-9 SCOPUS: 0037824791. .
Basu J., Bousbaa H., Logarinho E., Li Z., Williams B., Lopes C., Sunkel C., Goldberg M.,
Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. Journal of Cell Biology146(1):13-28, 1999. [Journal: Article] [CI: 163] [IF: 12,9]
DOI: 10.1083/jcb.146.1.13 SCOPUS: 0033549477. .
A quantitative analysis of growth control in the Drosophila eye disc. Development143(9):1482-1490, 2016. [Journal: Article] [CI: 9] [IF: 5,8]
DOI: 10.1242/dev.129775 SCOPUS: 84964847429. .
Piñeiro C., Lopes C., Casares F.,
A conserved transcriptional network regulates lamina development in the Drosophila visual system. Development141(14):2838-2847, 2014. [Journal: Article] [CI: 9] [IF: 6,5]
DOI: 10.1242/dev.108670 SCOPUS: 84903977990. .
Royo J., Maeso I., Irimia M., Gao F., Peter I., Lopes C., D'Aniello S., Casares F., Davidson E., Garcia-Fernández J., Gómez-Skarmeta J.,
Transphyletic conservation of developmental regulatory state in animal evolution. Proceedings of the National Academy of Sciences of the United States of America108(34):14186-14191, 2011. [Journal: Article] [CI: 53] [IF: 9,7]
DOI: 10.1073/pnas.1109037108 SCOPUS: 80052152362. .
Lopes C., Casares F.,
Hth maintains the pool of eye progenitors and its downregulation by Dpp and Hh couples retinal fate acquisition with cell cycle exit. Developmental Biology339(1):78-88, 2010. [Journal: Article] [CI: 42] [IF: 4,1]
DOI: 10.1016/j.ydbio.2009.12.020 SCOPUS: 77649188502. .
Maia A., Lopes C., Sunkel C.,
BubR1 and CENP-E have antagonistic effects upon the stability of microtubule-kinetochore attachments in Drosophila S2 cell mitosis. Cell Cycle6(11):1367-1378, 2007. [Journal: Article] [CI: 25] [IF: 3,3]
DOI: 10.4161/cc.6.11.4271 SCOPUS: 34547702755. .
Lopes C., Sampaio P., Williams B., Goldberg M., Sunkel C.,
The Drosophila Bub3 protein is required for the mitotic checkpoint and for normal accumulation of cyclins during G2 and early stages of mitosis. Journal of Cell Science118(1):187-198, 2005. [Journal: Article] [CI: 32] [IF: 6,5]
DOI: 10.1242/jcs.01602 SCOPUS: 14044275563. .
Logarinho E., Bousbaa H., Dias J., Lopes C., Amorim I., Antunes-Martins A., Sunkel C.,
Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cells. Journal of Cell Science117(9):1757-1771, 2004. [Journal: Article] [CI: 85] [IF: 6,9]
DOI: 10.1242/jcs.01033 SCOPUS: 2342429609. .
Lopes C., Sunkel C.,
The spindle checkpoint: From normal cell division to tumorigenesis. Archives of Medical Research34(3):155-165, 2003. [Journal: Review] [CI: 15] [IF: 1,3]
DOI: 10.1016/S0188-4409(03)00024-9 SCOPUS: 0037824791. .
Basu J., Bousbaa H., Logarinho E., Li Z., Williams B., Lopes C., Sunkel C., Goldberg M.,
Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. Journal of Cell Biology146(1):13-28, 1999. [Journal: Article] [CI: 163] [IF: 12,9]
DOI: 10.1083/jcb.146.1.13 SCOPUS: 0033549477. .