Teresa Summavielle
Addiction Biology
Group leader
Teresa Summavielle (IBMC) has a degree in Biochemistry and a PhD in development of the nervous system under exposure to psychostimulant drugs. She is the Head of the Addiction Biology Group at i3S.This research group explores the mechanisms of neurotoxicity induced by exposure to different drugs of abuse. Her major publications focused the effects of ecstasy in the adolescent brain, more recently she become interested in the effects of psychostimulants at the level of neuronal morphology and also in neuroinflammation. Neuroprotection was always a major goal of her research. She coordinates courses in Neurobiology of Addiction in two doctoral programs (University of Porto) and she is an invited Professor at the Allied Scholl of Health in Porto (ESS-PP). She has also a particular interest in Science Communication as a tool to prevent drug abuse in the adolescent.
Selected Publications
Andrade E.B., Magalhães A., Puga A., Costa M., Bravo J., Portugal C.C., Ribeiro A., Correia-Neves M., Faustino A., Firon A., Trieu-Cuot P., Summavielle T., Ferreira P.,
A mouse model reproducing the pathophysiology of neonatal groupαB streptococcal infection. Nature Communications9(1):, 2018. [Journal: Article] [CI: 8] [IF: 11,9]
DOI: 10.1038/s41467-018-05492-y SCOPUS: 85051277907. .
Braz S.O., Cruz A., Lobo A., Bravo J., Moreira-Ribeiro J., Pereira-Castro I., Freitas J., Relvas J.B., Summavielle T., Moreira A.,
Expression of Rac1 alternative 3' UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms1860(6):685-694, 2017. [Journal: Article] [CI: 2] [IF: 5,2]
DOI: 10.1016/j.bbagrm.2017.03.002 SCOPUS: 85018940086. .
Fernandes S., Salta S., Bravo J., Silva A.P., Summavielle T.,
Acetyl-L-Carnitine Prevents Methamphetamine-Induced Structural Damage on Endothelial Cells via ILK-Related MMP-9 Activity. Molecular Neurobiology53(1):408-422, 2016. [Journal: Article] [CI: 15] [IF: 6,2]
DOI: 10.1007/s12035-014-8973-5 SCOPUS: 84953357442. .
Coelho-Santos V., Socodato R., Portugal C., Leitão R.A., Rito M., Barbosa M., Couraud P.O., Romero I.A., Weksler B., Minshall R.D., Fontes-Ribeiro C., Summavielle T., Relvas J.B., Silva A.P.,
Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells. Cellular and Molecular Life Sciences73(24):4701-4716, 2016. [Journal: Article] [CI: 15] [IF: 5,8]
DOI: 10.1007/s00018-016-2301-3 SCOPUS: 84976878471. .
Teixeira-Castro A., Jalles A., Esteves S., Kang S., Da Silva Santos L., Silva-Fernandes A., Neto M.F., Brielmann R.M., Bessa C., Duarte-Silva S., Miranda A., Oliveira S., Neves-Carvalho A., Bessa J., Summavielle T., Silverman R.B., Oliveira P., Morimoto R.I., Maciel P.,
Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain138(11):3221-3237, 2015. [Journal: Article] [CI: 35] [IF: 10,1]
DOI: 10.1093/brain/awv262 SCOPUS: 84947806720. .
Venâncio C., Félix L., Almeida V., Coutinho J., Antunes L., Peixoto F., Summavielle T.,
Acute ketamine impairs mitochondrial function and promotes superoxide dismutase activity in the rat brain. Anesthesia and Analgesia120(2):320-328, 2015. [Journal: Article] [CI: 28] [IF: 3,8]
DOI: 10.1213/ANE.0000000000000539 SCOPUS: 84922337300. .
Ribeiro Do Couto B., Daza-Losada M., Rodríguez-Arias M., Nadal R., Guerri C., Summavielle T., Miñarro J., Aguilar M.A.,
Adolescent pre-exposure to ethanol and 3,4-methylenedioxymethylamphetamine (MDMA) increases conditioned rewarding effects of MDMA and drug-induced reinstatement. Addiction Biology17(3):588-600, 2012. [Journal: Article] [CI: 21] [IF: 5,9]
DOI: 10.1111/j.1369-1600.2011.00382.x SCOPUS: 84860240599. .
Baptista S., Bento A.R., Gonalves J., Bernardino L., Summavielle T., Lobo A., Fontes-Ribeiro C., Malva J.O., Agasse F., Silva A.P.,
Neuropeptide y promotes neurogenesis and protection against methamphetamine-induced toxicity in mouse dentate gyrus-derived neurosphere cultures. Neuropharmacology62(7):2413-2423, 2012. [Journal: Article] [CI: 30] [IF: 4,1]
DOI: 10.1016/j.neuropharm.2012.02.015 SCOPUS: 84859111071. .
Alves E., Summavielle T., Alves C.J., Gomes-da-Silva J., Barata J.C., Fernandes E., Bastos M.D.L., Tavares M.A., Carvalho F.,
Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria. Journal of Neuroscience27(38):10203-10210, 2007. [Journal: Article] [CI: 57] [IF: 7,5]
DOI: 10.1523/JNEUROSCI.2645-07.2007 SCOPUS: 34548842751. .
Alves E., Summavielle T., Alves C.J., Custódio J.B.A., Fernandes E., De Lourdes Bastos M., Tavares M.A., Carvalho F.,
Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: Influence of monoamine oxidase type A. Addiction Biology14(2):185-193, 2009. [Journal: Article] [CI: 34] [IF: 4,7]
DOI: 10.1111/j.1369-1600.2008.00143.x SCOPUS: 61849137910. .
A mouse model reproducing the pathophysiology of neonatal groupαB streptococcal infection. Nature Communications9(1):, 2018. [Journal: Article] [CI: 8] [IF: 11,9]
DOI: 10.1038/s41467-018-05492-y SCOPUS: 85051277907. .
Braz S.O., Cruz A., Lobo A., Bravo J., Moreira-Ribeiro J., Pereira-Castro I., Freitas J., Relvas J.B., Summavielle T., Moreira A.,
Expression of Rac1 alternative 3' UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms1860(6):685-694, 2017. [Journal: Article] [CI: 2] [IF: 5,2]
DOI: 10.1016/j.bbagrm.2017.03.002 SCOPUS: 85018940086. .
Fernandes S., Salta S., Bravo J., Silva A.P., Summavielle T.,
Acetyl-L-Carnitine Prevents Methamphetamine-Induced Structural Damage on Endothelial Cells via ILK-Related MMP-9 Activity. Molecular Neurobiology53(1):408-422, 2016. [Journal: Article] [CI: 15] [IF: 6,2]
DOI: 10.1007/s12035-014-8973-5 SCOPUS: 84953357442. .
Coelho-Santos V., Socodato R., Portugal C., Leitão R.A., Rito M., Barbosa M., Couraud P.O., Romero I.A., Weksler B., Minshall R.D., Fontes-Ribeiro C., Summavielle T., Relvas J.B., Silva A.P.,
Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells. Cellular and Molecular Life Sciences73(24):4701-4716, 2016. [Journal: Article] [CI: 15] [IF: 5,8]
DOI: 10.1007/s00018-016-2301-3 SCOPUS: 84976878471. .
Teixeira-Castro A., Jalles A., Esteves S., Kang S., Da Silva Santos L., Silva-Fernandes A., Neto M.F., Brielmann R.M., Bessa C., Duarte-Silva S., Miranda A., Oliveira S., Neves-Carvalho A., Bessa J., Summavielle T., Silverman R.B., Oliveira P., Morimoto R.I., Maciel P.,
Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain138(11):3221-3237, 2015. [Journal: Article] [CI: 35] [IF: 10,1]
DOI: 10.1093/brain/awv262 SCOPUS: 84947806720. .
Venâncio C., Félix L., Almeida V., Coutinho J., Antunes L., Peixoto F., Summavielle T.,
Acute ketamine impairs mitochondrial function and promotes superoxide dismutase activity in the rat brain. Anesthesia and Analgesia120(2):320-328, 2015. [Journal: Article] [CI: 28] [IF: 3,8]
DOI: 10.1213/ANE.0000000000000539 SCOPUS: 84922337300. .
Ribeiro Do Couto B., Daza-Losada M., Rodríguez-Arias M., Nadal R., Guerri C., Summavielle T., Miñarro J., Aguilar M.A.,
Adolescent pre-exposure to ethanol and 3,4-methylenedioxymethylamphetamine (MDMA) increases conditioned rewarding effects of MDMA and drug-induced reinstatement. Addiction Biology17(3):588-600, 2012. [Journal: Article] [CI: 21] [IF: 5,9]
DOI: 10.1111/j.1369-1600.2011.00382.x SCOPUS: 84860240599. .
Baptista S., Bento A.R., Gonalves J., Bernardino L., Summavielle T., Lobo A., Fontes-Ribeiro C., Malva J.O., Agasse F., Silva A.P.,
Neuropeptide y promotes neurogenesis and protection against methamphetamine-induced toxicity in mouse dentate gyrus-derived neurosphere cultures. Neuropharmacology62(7):2413-2423, 2012. [Journal: Article] [CI: 30] [IF: 4,1]
DOI: 10.1016/j.neuropharm.2012.02.015 SCOPUS: 84859111071. .
Alves E., Summavielle T., Alves C.J., Gomes-da-Silva J., Barata J.C., Fernandes E., Bastos M.D.L., Tavares M.A., Carvalho F.,
Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria. Journal of Neuroscience27(38):10203-10210, 2007. [Journal: Article] [CI: 57] [IF: 7,5]
DOI: 10.1523/JNEUROSCI.2645-07.2007 SCOPUS: 34548842751. .
Alves E., Summavielle T., Alves C.J., Custódio J.B.A., Fernandes E., De Lourdes Bastos M., Tavares M.A., Carvalho F.,
Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: Influence of monoamine oxidase type A. Addiction Biology14(2):185-193, 2009. [Journal: Article] [CI: 34] [IF: 4,7]
DOI: 10.1111/j.1369-1600.2008.00143.x SCOPUS: 61849137910. .