Where Ideas grow
José Bessa
Principal Researcher
JBessa completed his PhD degree in Developmental Biology at ICBAS (University of Porto; 2008), acquiring advanced knowledge in the development of Drosophila and Zebrafish visual systems, under the supervision of Dr. FCasares. As a postdoc, JBessa has joined the lab of Dr. JLGomez-Skarmeta, an expert in zebrafish Functional Genomics. Currently JBessa is developing an independent research line on transcriptional cis-regulation and gene function in the zebrafish pancreas.

Selected Publications

Seixas A., Loureiro J., Costa C., Ordóñez-Ugalde A., Marcelino H., Oliveira C., Loureiro J., Dhingra A., Brandão E., Cruz V., Timóteo A., Quintáns B., Rouleau G., Rizzu P., Carracedo Á., Bessa J., Heutink P., Sequeiros J., Sobrido M., Coutinho P., Silveira I.,
A Pentanucleotide ATTTC Repeat Insertion in the Non-coding Region of DAB1, Mapping to SCA37, Causes Spinocerebellar Ataxia. American Journal of Human Genetics101(1):87-103, 2017. [Journal: Article] [CI: 15] [IF: 8,9]
DOI: 10.1016/j.ajhg.2017.06.007 SCOPUS: 85021415706. .

Ariza-Cosano A., Bensimon-Brito A., Gómez-Skarmeta J., Bessa J.,
sox21a directs lateral line patterning by modulating FGF signaling. Developmental Neurobiology75(1):80-92, 2015. [Journal: Article] [CI: 2] [IF: 2,5]
DOI: 10.1002/dneu.22211 SCOPUS: 84919392179. .

Rodríguez-Seguí S., Bessa J.,
Gatekeepers of pancreas: TEAD and YAP. Oncotarget6(18):15736-15737, 2015. [Journal: Editorial] [CI: 1] [IF: 5]
DOI: 10.18632/oncotarget.4607 SCOPUS: 84937964234. .

Cebola I., Rodríguez-Seguí S., Cho C., Bessa J., Rovira M., Luengo M., Chhatriwala M., Berry A., Ponsa-Cobas J., Maestro M., Jennings R., Pasquali L., Morán I., Castro N., Hanley N., Gomez-Skarmeta J., Vallier L., Ferrer J.,
TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Nature Cell Biology17(5):615-626, 2015. [Journal: Article] [CI: 71] [IF: 18,7]
DOI: 10.1038/ncb3160 SCOPUS: 84928938629. .

Spieler D., Kaffe M., Knauf F., Bessa J., Tena J., Giesert F., Schormair B., Tilch E., Lee H., Horsch M., Czamara D., Karbalai N., Toerne C., Waldenberger M., Gieger C., Lichtner P., Claussnitzer M., Naumann R., Müller-Myhsok B., Torres M., Garrett L., Rozman J., Klingenspor M., Gailus-Durner V., Fuchs H., De Angelis M., Beckers J., Hölter S., Meitinger T., Hauck S., Laumen H., Wurst W., Casares F., Gómez-Skarmeta J., Winkelmann J.,
Restless Legs Syndrome-Associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Research24(4):592-603, 2014. [Journal: Article] [CI: 42] [IF: 14,6]
DOI: 10.1101/gr.166751.113 SCOPUS: 84898747287. .

Bessa J., Luengo M., Rivero-Gil S., Ariza-Cosano A., Maia A., Ruiz-Ruano F., Caballero P., Naranjo S., Carvajal J., Gómez-Skarmeta J.,
A mobile insulator system to detect and disrupt cis-regulatory landscapes in vertebrates. Genome Research24(3):487-495, 2014. [Journal: Article] [CI: 3] [IF: 14,6]
DOI: 10.1101/gr.165654.113 SCOPUS: 84895553255. .

Regadas I., Matos M., Monteiro F., Gömez-Skarmeta J., Lima D., Bessa J., Casares F., Reguenga C.,
Several Cis-regulatory Elements Control mRNA Stability, Translation Efficiency, and Expression Pattern of Prrxl1(Paired Related Homeobox Protein-like 1). Journal of Biological Chemistry288(51):36285-36301, 2013. [Journal: Article] [CI: 6] [IF: 4,6]
DOI: 10.1074/jbc.M113.491993 SCOPUS: 84890912110. .

Ariza-Cosano A., Visel A., Pennacchio L., Fraser H., Gómez-Skarmeta J., Irimia M., Bessa J.,
Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression. BMC Genomics13(1):, 2012. [Journal: Article] [CI: 15] [IF: 4,4]
DOI: 10.1186/1471-2164-13-713 SCOPUS: 84871117732. .

Royo J., Bessa J., Hidalgo C., Fernández-Miñán A., Tena J., Roncero Y., Gómez-Skarmeta J., Casares F.,
Identification and analysis of conserved cis-regulatory regions of the MEIS1 gene. PLoS ONE7(3):, 2012. [Journal: Article] [CI: 12] [IF: 3,7]
DOI: 10.1371/journal.pone.0033617 SCOPUS: 84858638769. .

Bessa J., Tena J., De La Calle-Mustienes E., Fernández-Miñán A., Naranjo S., Fernández A., Montoliu L., Akalin A., Lenhard B., Casares F., Gómez-Skarmeta J.,
Zebrafish Enhancer Detection (ZED) vector: A new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish. Developmental Dynamics238(9):2409-2417, 2009. [Journal: Article] [CI: 85] [IF: 2,8]
DOI: 10.1002/dvdy.22051 SCOPUS: 70349085853. .