Where Ideas grow
Andreia Almeida
PhD Student

I am graduated in Biomedical Engineering at the University of Porto (UP) since 2016 and started a PhD in Biomedical Sciences at INEB/i3S, Institute of Biomedical Engineering/Institute for Investigation and Innovation in Health (UP) in 2017, in collaboration with Vall d'Hebron Research Institute (ES) and University of Minho (PT). Also, during my PhD, I conducted three short term scientific missions at Technion - Israel Institute of Technology (IL), University of Seville (ES) and MJRPharmaJet Industry (DE). The main focus of my PhD project is to design a new chitosan amphiphilic derivative with ability to form micelles by self-assembly. These polymeric micelles are able to efficiently encapsulate hydrophobic molecules, as many anticancer drugs, in order to improve its solubility and oral bioavailability. I have extended my expertise on physico-chemical characterization of polymers, as well as in in vitro cell culture studies andin vivo animal models.

Selected Publications

Almeida A., Araújo M., Novoa-Carballal R., Andrade F., Gonçalves H., Reis R.L., Lúcio M., Schwartz S., Sarmento B.,
Novel amphiphilic chitosan micelles as carriers for hydrophobic anticancer drugs. Materials Science and Engineering C112:, 2020. [Journal: Article] [CI: 8] [IF: 5,9 (*)]
DOI: 10.1016/j.msec.2020.110920 SCOPUS: 85082759835.

Eliyahu S., Almeida A., Macedo M.H., das Neves J., Sarmento B., Bianco-Peled H.,
The effect of freeze-drying on mucoadhesion and transport of acrylated chitosan nanoparticles. International Journal of Pharmaceutics573:, 2020. [Journal: Article] [CI: 5] [IF: 4,8 (*)]
DOI: 10.1016/j.ijpharm.2019.118739 SCOPUS: 85076199707.

Heep G., Almeida A., Marcano R., Vieira D., Mainardes R.M., Khalil N.M., Sarmento B.,
Zein-casein-lysine multicomposite nanoparticles are effective in modulate the intestinal permeability of ferulic acid. International Journal of Biological Macromolecules138:244-251, 2019. [Journal: Article] [CI: 5] [IF: 5,2]
DOI: 10.1016/j.ijbiomac.2019.07.030 SCOPUS: 85070731306.

Almeida A., Silva D., Gonçalves V., Sarmento B.,
Synthesis and characterization of chitosan-grafted-polycaprolactone micelles for modulate intestinal paclitaxel delivery. Drug Delivery and Translational Research8(2):387-397, 2018. [Journal: Article] [CI: 18] [IF: 3,1]
DOI: 10.1007/s13346-017-0357-8 SCOPUS: 85042686155.

Silva D.S., Dos Santos D.M., Almeida A., Marchiori L., Campana-Filho S.P., Ribeiro S.J.L., Sarmento B.,
N-(2-hydroxy)-propyl-3-trimethylammonium, o-mysristoyl chitosan enhances the solubility and intestinal permeability of anticancer curcumin. Pharmaceutics10(4):, 2018. [Journal: Article] [CI: 8] [IF: 4,8]
DOI: 10.3390/pharmaceutics10040245 SCOPUS: 85057076206.

Sgorla D., Lechanteur A., Almeida A., Sousa F., Melo E., Bunhak É., Mainardes R., Khalil N., Cavalcanti O., Sarmento B.,
Development and characterization of lipid-polymeric nanoparticles for oral insulin delivery. Expert Opinion on Drug Delivery15(3):213-222, 2018. [Journal: Article] [CI: 16] [IF: 5,4]
DOI: 10.1080/17425247.2018.1420050 SCOPUS: 85039164036.

Almeida A., Sarmento B., Rodrigues F.,
Insights on in vitro models for safety and toxicity assessment of cosmetic ingredients. International Journal of Pharmaceutics519(1-2):178-185, 2017. [Journal: Review] [CI: 21] [IF: 3,9]
DOI: 10.1016/j.ijpharm.2017.01.024 SCOPUS: 85010022043.

Silva D.S., Almeida A., Prezotti F., Cury B., Campana-Filho S.P., Sarmento B.,
Synthesis and characterization of 3,6-O,O’- dimyristoyl chitosan micelles for oral delivery of paclitaxel. Colloids and Surfaces B: Biointerfaces152:220-228, 2017. [Journal: Article] [CI: 23] [IF: 4]
DOI: 10.1016/j.colsurfb.2017.01.029 SCOPUS: 85009982285.

Lechanteur A., Almeida A., Sarmento B.,
Elucidation of the impact of cell culture conditions of Caco-2 cell monolayer on barrier integrity and intestinal permeability. European Journal of Pharmaceutics and Biopharmaceutics119:137-141, 2017. [Journal: Article] [CI: 14] [IF: 4,5]
DOI: 10.1016/j.ejpb.2017.06.013 SCOPUS: 85020550395.

Silva D.S., Almeida A., Prezotti F.G., Facchinatto W.M., Colnago L.A., Campana-Filho S.P., Sarmento B.,
Self-aggregates of 3,6-O,O’-dimyristoylchitosan derivative are effective in enhancing the solubility and intestinal permeability of camptothecin. Carbohydrate Polymers177:178-186, 2017. [Journal: Article] [CI: 10] [IF: 5,2]
DOI: 10.1016/j.carbpol.2017.08.114 SCOPUS: 85028727784.