Marina Leite
Hematopoiesis and Microenvironments
Junior Researcher
Marina Leite is a post-doctoral fellow from the Epithelial Interactions in Cancer (EPIC) group at IPATIMUP. Marina's current research interests aim to elucidate the cellular and molecular mechanisms by which Helicobacter pylori promote gastric carcinogenesis, mainly through the interaction with receptor tyrosine kinases and cell-cell adhesion molecules. More recently, she is exploring the role of H. pylori-derived outer membrane vesicles (OMV) in the alteration of the host gene expression, focusing on DNA repair genes, that might contribute to the development of H. pylori-associated diseases, mainly gastric cancer. She has published 20 peer-reviewed papers, 5 book chapters, with an h-index of 13, and is a principal investigator in a transnational joint project between FCT and CAPES.
Selected Publications
Melo J., Cavadas B., Pereira L., Figueiredo C., Leite M.,
Melo J., Pinto V., Fernandes T., Malheiro A.R., Osório H., Figueiredo C., Leite M.,
Marques M.S., Costa A.C., Osório H., Pinto M.L., Relvas S., Dinis-Ribeiro M., Carneiro F., Leite M., Figueiredo C.,
Leite M., Marques M.S., Melo J., Pinto M.T., Cavadas B., Aroso M., Gomez-Lazaro M., Seruca R., Figueiredo C.,
Marques M.S., Melo J., Cavadas B., Mendes N., Pereira L., Carneiro F., Figueiredo C., Leite M.,
Figueiredo C., Constanza Camargo M., Leite M., Fuentes-Pananá E.M., Rabkin C.S., Machado J.C.,
Velho S., Fernandes M.S., Leite M., Figueiredo C., Seruca R.,
Leite M., Corso G., Sousa S., Milanezi F., Afonso L.P., Henrique R., Soares J.M., Castedo S., Carneiro F., Roviello F., Oliveira C., Seruca R.,
Pedrazzani C., Corso G., Velho S., Leite M., Pascale V., Bettarini F., Marrelli D., Seruca R., Roviello F.,
Lima M., Dos Anjos Teixeira M., Queirós M.L., Leite M., Santos A.H., Justiça B., Orfão A.,
Transcriptomic remodeling of gastric cells by Helicobacter pylori outer membrane vesicles. Helicobacter29(1):, 2024. [Journal: Article] [IF: 4,4 (*)]
DOI: 10.1111/hel.13031 SCOPUS: 85177562621.
DOI: 10.1111/hel.13031 SCOPUS: 85177562621.
Melo J., Pinto V., Fernandes T., Malheiro A.R., Osório H., Figueiredo C., Leite M.,
Isolation Method and Characterization of Outer Membranes Vesicles of Helicobacter pylori Grown in a Chemically Defined Medium. Frontiers in Microbiology12:, 2021. [Journal: Article] [CI: 12] [IF: 6,1]
DOI: 10.3389/fmicb.2021.654193 SCOPUS: 85108164338.
DOI: 10.3389/fmicb.2021.654193 SCOPUS: 85108164338.
Marques M.S., Costa A.C., Osório H., Pinto M.L., Relvas S., Dinis-Ribeiro M., Carneiro F., Leite M., Figueiredo C.,
Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity. Gut Microbes13(1):1-21, 2021. [Journal: Article] [CI: 8] [IF: 9,4]
DOI: 10.1080/19490976.2021.1921928 SCOPUS: 85105768485.
DOI: 10.1080/19490976.2021.1921928 SCOPUS: 85105768485.
Leite M., Marques M.S., Melo J., Pinto M.T., Cavadas B., Aroso M., Gomez-Lazaro M., Seruca R., Figueiredo C.,
Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions. Cells9(2):, 2020. [Journal: Article] [CI: 17] [IF: 6,6]
DOI: 10.3390/cells9020513 SCOPUS: 85086741184.
DOI: 10.3390/cells9020513 SCOPUS: 85086741184.
Marques M.S., Melo J., Cavadas B., Mendes N., Pereira L., Carneiro F., Figueiredo C., Leite M.,
Afadin downregulation by helicobacter pyloriInduces epithelial to mesenchymal transition in gastric cells. Frontiers in Microbiology9(NOV):, 2018. [Journal: Article] [CI: 19] [IF: 4,3]
DOI: 10.3389/fmicb.2018.02712 SCOPUS: 85056637997.
DOI: 10.3389/fmicb.2018.02712 SCOPUS: 85056637997.
Figueiredo C., Constanza Camargo M., Leite M., Fuentes-Pananá E.M., Rabkin C.S., Machado J.C.,
Pathogenesis of gastric cancer: Genetics and molecular classification. Current Topics in Microbiology and Immunology400:277-304, 2017. [Book Series: Book Chapter] [CI: 97] [IF: 5,8]
DOI: 10.1007/978-3-319-50520-6_12 SCOPUS: 85010908079.
DOI: 10.1007/978-3-319-50520-6_12 SCOPUS: 85010908079.
Velho S., Fernandes M.S., Leite M., Figueiredo C., Seruca R.,
Causes and consequences of microsatellite instability in gastric carcinogenesis. World Journal of Gastroenterology20(44):16433-16442, 2014. [Journal: Article] [CI: 60] [IF: 2,4]
DOI: 10.3748/wjg.v20.i44.16433 SCOPUS: 84918813931.
DOI: 10.3748/wjg.v20.i44.16433 SCOPUS: 84918813931.
Leite M., Corso G., Sousa S., Milanezi F., Afonso L.P., Henrique R., Soares J.M., Castedo S., Carneiro F., Roviello F., Oliveira C., Seruca R.,
MSI phenotype and MMR alterations in familial and sporadic gastric cancer. International Journal of Cancer128(7):1606-1613, 2011. [Journal: Article] [CI: 60] [IF: 5,4]
DOI: 10.1002/ijc.25495 SCOPUS: 79551478326.
DOI: 10.1002/ijc.25495 SCOPUS: 79551478326.
Pedrazzani C., Corso G., Velho S., Leite M., Pascale V., Bettarini F., Marrelli D., Seruca R., Roviello F.,
Evidence of tumor microsatellite instability in gastric cancer with familial aggregation. Familial Cancer8(3):215-220, 2009. [Journal: Article] [CI: 43] [IF: 2,2]
DOI: 10.1007/s10689-008-9231-7 SCOPUS: 68449100164.
DOI: 10.1007/s10689-008-9231-7 SCOPUS: 68449100164.
Lima M., Dos Anjos Teixeira M., Queirós M.L., Leite M., Santos A.H., Justiça B., Orfão A.,
Immunophenotypic characterization of normal blood CD56+loversus CD56+hiNK-cell subsets and its impact on the understanding of their tissue distribution and functional properties. Blood Cells, Molecules, and Diseases27(4):731-743, 2001. [Journal: Article] [CI: 56] [IF: 1,7]
DOI: 10.1006/bcmd.2001.0443 SCOPUS: 0034748087.
DOI: 10.1006/bcmd.2001.0443 SCOPUS: 0034748087.