Where Ideas grow
Sandra Ribeiro
Neurobiology & Neurologic Disorders Program vice-Coordinator
Sandra de Macedo Ribeiro has a background in Structural Biology, holds a degree in Biochemistry from the University of Porto (Portugal) and a Ph.D. from the Technical University of Munich Germany. Her training in Protein Crystallography started in 1992 as an Erasmus student at the University of Aarhus (Denmark) and proceeded during her Ph.D research at the Max-Planck Institut fuer Biochemie, Martinsried, Germany. In 2001-2002, following a post-Doctoral fellowship at IBMC-CSIC (Barcelona, Spain), Sandra moved to the University of Algarve (Portugal) as a Biochemistry Professor and later to the Center of Neuroscience and Cell Biology (Coimbra, Portugal) where she lead the Protein Structure Group. In 2006, Sandra joined the Institute for Molecular and Cellular Biology (Porto, Portugal), where she leads the Protein Crystallography Group. Research in Sandra Macedo Ribeiro lab focuses on the structural and functional characterization of biomedically relevant proteins, with a special emphasis on understanding the modulatory role of intermolecular interactions on proteins associated with neurodegenerative diseases.

Selected Publications

Piovesan D., Tabaro F., Micetic I., Necci M., Quaglia F., Oldfield C.J., Aspromonte M.C., Davey N.E., Davidovic R., Dosztányi Z., Elofsson A., Gasparini A., Hatos A., Kajava A.V., Kalmar L., Leonardi E., Lazar T., Macedo-Ribeiro S., Macossay-Castillo M., Meszaros A., Minervini G., Murvai N., Pujols J., Roche D.B., Salladini E., Schad E., Schramm A., Szabo B., Tantos A., Tonello F., Tsirigos K.D., Veljkovic N., Ventura S., Vranken W., Warholm P., Uversky V.N., Dunker A.K., Longhi S., Tompa P., Tosatto S.C.E.,
DisProt 7.0: A major update of the database of disordered proteins. Nucleic Acids Research45(D1):D219-D227, 2017. [Journal: Article] [CI: 123] [IF: 11,6]
DOI: 10.1093/nar/gkw1056 SCOPUS: 85016112986.


Silva A., Almeida B., Fraga J.S., Taboada P., Martins P.M., Macedo-Ribeiro S.,
Distribution of Amyloid-Like and Oligomeric Species from Protein Aggregation Kinetics. Angewandte Chemie - International Edition56(45):14042-14045, 2017. [Journal: Article] [CI: 7] [IF: 12,1]
DOI: 10.1002/anie.201707345 SCOPUS: 85032264546.


Merski M., Moreira C., Abreu R.M.V., Ramos M.J., Fernandes P.A., Martins L.M., Pereira P.J.B., Macedo-Ribeiro S.,
Molecular motion regulates the activity of the mitochondrial serine protease HtrA2. Cell Death and Disease8(10):, 2017. [Journal: Article] [CI: 5] [IF: 5,6]
DOI: 10.1038/cddis.2017.487 SCOPUS: 85031277139.


Silva A., de Almeida A.V., Macedo-Ribeiro S.,
Polyglutamine expansion diseases: More than simple repeats. Journal of Structural Biology201(2):139-154, 2018. [Journal: Article] [CI: 9] [IF: 3,8]
DOI: 10.1016/j.jsb.2017.09.006 SCOPUS: 85029698528.


Matos C.A., Nóbrega C., Louros S.R., Almeida B., Ferreiro E., Valero J., De Almeida L.P., Macedo-Ribeiro S., Carvalho A.L.,
Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models. Journal of Cell Biology212(4):465-480, 2016. [Journal: Article] [CI: 19] [IF: 8]
DOI: 10.1083/jcb.201506025 SCOPUS: 84959536774.


Santos J.A., Alonso-Garciá N., Macedo-Ribeiro S., Barbosa Pereira P.J.,
The unique regulation of iron-sulfur cluster biogenesis in a Gram-positive bacterium. Proceedings of the National Academy of Sciences of the United States of America111(22):, 2014. [Journal: Article] [CI: 25] [IF: 9,7]
DOI: 10.1073/pnas.1322728111 SCOPUS: 84901821729.


Almeida B., Fernandes S., Abreu I.A., Macedo-Ribeiro S.,
Trinucleotide repeats: A structural perspective. Frontiers in Neurology4 JUN:, 2013. [Journal: Review] [CI: 33]
DOI: 10.3389/fneur.2013.00076 SCOPUS: 84883533687.


Scarff C.A., Sicorello A., Tomé R.J.L., MacEdo-Ribeiro S., Ashcroft A.E., Radford S.E.,
A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3. International Journal of Mass Spectrometry345-347:63-70, 2013. [Journal: Article] [CI: 12] [IF: 2,2]
DOI: 10.1016/j.ijms.2012.08.032 SCOPUS: 84878844824.


Rocha R., Pereira P.J.B., Santos M.A.S., Macedo-Ribeiro S.,
Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen. Proceedings of the National Academy of Sciences of the United States of America108(34):14091-14096, 2011. [Journal: Article] [CI: 29] [IF: 9,7]
DOI: 10.1073/pnas.1102835108 SCOPUS: 80052182956.