Jorge Ripoll Rozada
Macromolecular Structure
Collaborator
Dr Jorge Ripoll graduated from the University of A Coruña (Spain) with a Bachelor of Biology degree in 2006. After that, he joined as a predoctoral student to the Molecular Motors Group at the IBBTEC (Santander, Spain) where he received his PhD in Molecular Biology and Biomedicine from the University of Cantabria in 2013. His PhD was focused on the enzymatic and functional regulation of a traffic ATPase belonging to the Type IV Secretion System. Since February of 2014, Jorge is a postdoctoral researcher to the Biomolecular Structure group at the IBMC (Porto, Portugal). His current research focusses on protein structure and function of potential drug targets from mycobacterial human pathogens. He is also interested in the molecular details of specific coagulation factor IIa recognition and inhibition by natural macromolecular anticoagulants from haematophagous parasites.
Selected Publications
Agten S.M., Watson E.E., Ripoll-Rozada J., Dowman L.J., Wu M.C.L., Alwis I., Jackson S.P., Pereira P.J.B., Payne R.J.,
Calisto B.M., Ripoll-Rozada J., Dowman L.J., Franck C., Agten S.M., Parker B.L., Veloso R.C., Vale N., Gomes P., de Sanctis D., Payne R.J., Pereira P.J.B.,
Watson E.E., Ripoll-Rozada J., Lee A.C., Wu M.C.L., Franck C., Pasch T., Premdjee B., Sayers J., Pinto M.F., Martins P.M., Jackson S.P., Pereira P.J.B., Payne R.J.,
Ripoll-Rozada J., Costa M., Manso J.A., Maranha A., Miranda V., Sequeira A., Rita Ventura M., Macedo-Ribeiro S., Pereira P.J.B., Empadinhas N.,
Watson E.E., Liu X., Thompson R.E., Ripoll-Rozada J., Wu M., Alwis I., Gori A., Loh C.T., Parker B.L., Otting G., Jackson S., Pereira P.J.B., Payne R.J.,
Thompson R.E., Liu X., Ripoll-Rozada J., Alonso-García N., Parker B.L., Pereira P.J.B., Payne R.J.,
Pirone L., Ripoll-Rozada J., Leone M., Ronca R., Lombardo F., Fiorentino G., Andersen J.F., Pereira P.J.B., Arcà B., Pedone E.,
Ripoll-Rozada J., García-Cazorla Y., Getino M., Machón C., Sanabria-Ríos D., de la Cruz F., Cabezón E., Arechaga I.,
Cabezón E., Ripoll-Rozada J., Peña A., de la Cruz F., Arechaga I.,
Ripoll-Rozada J., Peña A., Rivas S., Moro F., De La Cruz F., Cabezo E., Arechaga I.,
Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods. Angewandte Chemie - International Edition60(10):5348-5356, 2021. [Journal: Article] [CI: 8] [IF: 16,8]
DOI: 10.1002/anie.202015127 SCOPUS: 85099868534.
DOI: 10.1002/anie.202015127 SCOPUS: 85099868534.
Calisto B.M., Ripoll-Rozada J., Dowman L.J., Franck C., Agten S.M., Parker B.L., Veloso R.C., Vale N., Gomes P., de Sanctis D., Payne R.J., Pereira P.J.B.,
Sulfotyrosine-Mediated Recognition of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological Substrates. Cell chemical biology28(1):26-33.e8, 2021. [Journal: Article] [CI: 12] [IF: 9]
DOI: 10.1016/j.chembiol.2020.10.002 SCOPUS: 85097103852.
DOI: 10.1016/j.chembiol.2020.10.002 SCOPUS: 85097103852.
Watson E.E., Ripoll-Rozada J., Lee A.C., Wu M.C.L., Franck C., Pasch T., Premdjee B., Sayers J., Pinto M.F., Martins P.M., Jackson S.P., Pereira P.J.B., Payne R.J.,
Rapid assembly and profiling of an anticoagulant sulfoprotein library. Proceedings of the National Academy of Sciences of the United States of America116(28):13873-13878, 2019. [Journal: Article] [CI: 23] [IF: 9,4]
DOI: 10.1073/pnas.1905177116 SCOPUS: 85066962891.
DOI: 10.1073/pnas.1905177116 SCOPUS: 85066962891.
Ripoll-Rozada J., Costa M., Manso J.A., Maranha A., Miranda V., Sequeira A., Rita Ventura M., Macedo-Ribeiro S., Pereira P.J.B., Empadinhas N.,
Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides. Proceedings of the National Academy of Sciences of the United States of America116(3):835-844, 2019. [Journal: Article] [CI: 6] [IF: 9,4]
DOI: 10.1073/pnas.1813450116 SCOPUS: 85060031004.
DOI: 10.1073/pnas.1813450116 SCOPUS: 85060031004.
Watson E.E., Liu X., Thompson R.E., Ripoll-Rozada J., Wu M., Alwis I., Gori A., Loh C.T., Parker B.L., Otting G., Jackson S., Pereira P.J.B., Payne R.J.,
Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics. ACS Central Science4(4):468-476, 2018. [Journal: Article] [CI: 30] [IF: 12,8]
DOI: 10.1021/acscentsci.7b00612 SCOPUS: 85045964682.
DOI: 10.1021/acscentsci.7b00612 SCOPUS: 85045964682.
Thompson R.E., Liu X., Ripoll-Rozada J., Alonso-García N., Parker B.L., Pereira P.J.B., Payne R.J.,
Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors. Nature Chemistry9(9):909-917, 2017. [Journal: Article] [CI: 66] [IF: 26,2]
DOI: 10.1038/NCHEM.2744 SCOPUS: 85028339870.
DOI: 10.1038/NCHEM.2744 SCOPUS: 85028339870.
Pirone L., Ripoll-Rozada J., Leone M., Ronca R., Lombardo F., Fiorentino G., Andersen J.F., Pereira P.J.B., Arcà B., Pedone E.,
Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae. Journal of Biological Chemistry292(30):12632-12642, 2017. [Journal: Article] [CI: 19] [IF: 4]
DOI: 10.1074/jbc.M117.788042 SCOPUS: 85026312710.
DOI: 10.1074/jbc.M117.788042 SCOPUS: 85026312710.
Ripoll-Rozada J., García-Cazorla Y., Getino M., Machón C., Sanabria-Ríos D., de la Cruz F., Cabezón E., Arechaga I.,
Type IV traffic ATPase TrwD as molecular target to inhibit bacterial conjugation. Molecular Microbiology100(5):912-921, 2016. [Journal: Article] [CI: 40] [IF: 3,9]
DOI: 10.1111/mmi.13359 SCOPUS: 84969802767.
DOI: 10.1111/mmi.13359 SCOPUS: 84969802767.
Cabezón E., Ripoll-Rozada J., Peña A., de la Cruz F., Arechaga I.,
Towards an integrated model of bacterial conjugation. FEMS Microbiology Reviews39(1):81-95, 2015. [Journal: Review] [CI: 194] [IF: 13,7]
DOI: 10.1111/1574-6976.12085 SCOPUS: 84932107470.
DOI: 10.1111/1574-6976.12085 SCOPUS: 84932107470.
Ripoll-Rozada J., Peña A., Rivas S., Moro F., De La Cruz F., Cabezo E., Arechaga I.,
Regulation of the type IV secretion ATPase TrwD by magnesium: Implications for catalytic mechanism of the secretion ATPase superfamily. Journal of Biological Chemistry287(21):17408-17414, 2012. [Journal: Article] [CI: 17] [IF: 4,7]
DOI: 10.1074/jbc.M112.357905 SCOPUS: 84861210647.
DOI: 10.1074/jbc.M112.357905 SCOPUS: 84861210647.