Where Ideas Grow

19th Portugaliæ Genetica - Phenotypic Manifestation of Genetic Heterogeneity
24-25 March 2022 | Online (Lisbon time - WEST time) 

 

WELCOME
After the challenges of the last two years, we are happy to finally announce the return of Portugaliae Genetica! We remain faithful to the previously proposed theme and look forward to welcoming you to join us in March 2022. The 19th Edition of Portugaliæ Genetica is devoted to the broad theme "Phenotypic Manifestation of Genetic Heterogeneity" and will have a transversal program covering exciting topics bridging population genetics, evolution, and functional genomics with health applications. In particular, it will cover inter and intra-species genetic diversity and its impact in diseases such as cancer, autism, and neurodegenerative diseases; the role of genome evolution in phenotypic outcomes, and interspecies bridging in disease modeling. The event hopes to contribute to the promotion of collaboration between researchers across these fields.

 

Poster >> 
 

Organization

Organizing Committee:
Iva Gomes, i3S, IPATIMUP 
Manuela Oliveira, i3S, IPATIMUP 
Mónica Marques, i3S, IPATIMUP 
Verónica Gomes, i3S, IPATIMUP 

Scientific Committee:
Iva Gomes, i3S, IPATIMUP 
Luísa Azevedo, i3S, IPATIMUP 

Invited Scientific Committee:
Elsa Logarinho, i3S, IBMC 
José Bessa, i3S, IBMC  

Program

THURSDAY, 24TH MARCH 2022 (All-day online event)

 

09:00 Welcome Note
Iva Gomes | IPATIMUP, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal

Opening Session
António Amorim | IPATIMUP, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal

 

SESSION 1 | Phenotypic outcomes of genome evolution
Chair 1: Luísa Azevedo | IPATIMUP, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal

9:15 Fitness peaks of orthologous proteins are not the same: lessons for protein design 
Fyodor Kondrashov | Institute of Science and Technology (IST), Klosterneuburg, Austria

10:15 Phenotypes Lost ... in the Water
Filipe Castro | CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Porto, Portugal

11.00 BREAK AND (VIRTUAL) POSTER SESSION

11.30 The evolution of organ development
Margarida Cardoso Moreira | The Francis Crick Institute, London, United Kingdom

12.15 Genetic and environmental determinants of phenotypic variation in complex traits. 
Patrícia Beldade | cE3c - Centre for Ecology, Evolution and Environmental Changes, Faculty of Sciences, University of Lisbon, Portugal

13.00 LUNCH BREAK AND (VIRTUAL) POSTER SESSION
 

 
SESSION 2 | Genetic heterogeneity in animal models 
Chair 2: José Bessa | IBMC, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal
 

14.15 Natural and unnatural genomic variation in zebrafish and goldfish
Shawn Burgess | National Institutes of Health (NIH), MD, USA

15.15 The European rabbit (Oryctolagus cuniculus) is an amazing model for almost everything. 
Pedro Esteves | CIBIO-InBIO- Research Centre in Biodiversity and Genetic Resources, Porto, Portugal

Short Communication Session #1

16.00 Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers.
Marta Duque | IBMC, i3S - Instituto de Investigação e Inovação em Saúde, ICBAS- Instituto de Ciências Biomédicas Abel Salazar University of Porto, Portugal

16.15 Approximate Bayesian Computation modeling of the successful out-of-Africa migration of modern humans. 
Catarina Branco | Biomedical Research Center (CINBIO), Department of Biochemistry, Genetics and Immunology, University of Vigo, Spain

16.30 Identifying the best-fitting substitution model of protein evolution accounting for structural constraints. 
David Ferreiro | Biomedical Research Center (CINBIO), Department of Biochemistry, Genetics and Immunology, University of Vigo, Spain

16.45 Evolutionary fluctuations of the HIV-1 protease folding stability. 
Miguel Arenas | Biomedical Research Center (CINBIO and Department of Biochemistry, Genetics and Immunology, University of Vigo, Spain, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal

 

FRIDAY, 25TH MARCH 2022 (MORNING SESSION, ONLINE)

SESSION 3 | Impact of genetic heterogeneity in diseases
Chair 3: António Amorim | IPATIMUP, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal

9.00 Immunosurveillance: a major driver of intra-tumor genetic heterogeneity
José Carlos Machado | IPATIMUP, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal

10.00 Rodent malaria models: Insights into parasite biology and implications on vaccines design
Joana Tavares | IBMC, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal 

10.45 From genes to treatments in Machado-Joseph disease: a tale of worms, mice and men
Patricia Maciel | University of Minho, Braga, Portugal

11.30 BREAK AND (VIRTUAL) POSTER SESSION

12.00 Presentation by Pfizer: Gene Therapy – State of the art
Ana Miranda | Medical Advisor Rare Disease

12.15 Presentation by ILC: From Spatial Discovery to Spatial Signatures, at Scale
Ivan Masetto | Field Application Scientist

Short Communication Session #2

12.30 Nucleotide polymorphisms associated to increased risk of pancreatic cancer modulate pancreatic enhancer’s function. 
Joana Teixeira | IBMC, i3S - Instituto de Investigação e Inovação em Saúde, ICBAS- Instituto de Ciências Biomédicas Abel Salazar University of Porto, Portugal

12.45 Scuba Cancers: heterogeneity of cockle transmissible cancers. 
Alicia Bruzos | CiMUS – Research Center of Molecular Medicine, University of Santiago de Compostela, 2ECIMAT – Toralla Marine Science Station, Universidade de Vigo, Spain. 

13.00 LUNCH BREAK AND (VIRTUAL) POSTER SESSION


 
AFTERNOON SESSION: Online & Mariano Gago Auditorium, IPATIMUP/i3S

SESSION 4 | Interspecies bridging in disease modeling
Chair 4: Elsa Logarinho | IBMC, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal

14.30 Genomic evolution of cancer models: Perils and opportunities
Uri Ben-David | Department of Human Molecular Genetics & Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Israel

15.30 Autism spectrum disorders: an example of genetic heterogeneity
Angel Carracedo | University of Santiago de Compostela, Spain

16.30 Quality and validity in animal research
Anna Olsson | IBMC, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal

 

17.15 Closing Session, Oral and Poster Awards
Iva Gomes | IPATIMUP, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal 
António Amorim | IPATIMUP, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal
 

Abstract Submission

The call for abstracts will be open until the 13th of February (notification of acceptance until the 18th of February).
The meeting will include poster sessions and the selection of 4 abstracts for short oral communications as part of the program, during which contributors will have the opportunity to introduce and attract attention to their research. During submission of abstracts, candidates can select their preference for oral or poster presentation format.

The best poster and the best oral communication will be awarded a prize sponsored by Pfizer. For more details, please read the regulation in attach.

 

Abstracts Guidelines:
- Title is limited to 150 characters (including spaces).
- Abstracts are limited to 1500 characters (including spaces; authors and affiliations excluded).
- Define all non-standard abbreviations at first use.
- Images cannot be included in the abstract.
- Abstracts should be submitted through the web interface.

The participants should use the layout provided here:

Abstract Template | Download  >> 

Abstract submission form >>
 

Registration

Fees:
i3S members & students - €25
External participants - €35

Registration Deadline: 25th February 2022
Payment Deadline: 28th February 2022

Please note that the meeting will be held live (Lisbon time - WEST time) and recordings will not be available.
A certificate of attendance will be issued after the meeting for participants that attend the event. The certificate will not be issued in case of a no-show.

 

Registration form >> 

Details for payment will be sent in the confirmation registration e-mail. 
 

Sponsors

Institutional support

  


Platinum sponsors


Silver sponsors

   


Bronze sponsors

  


More information:
Events Management Unit | Rua Alfredo Allen 208 | 4200-135 Porto, Portugal
Email: events@i3s.up.pt | Tel: +351 220 408 811