Where Ideas grow

1st Symposium on
Oligonucleotide Technologies and Therapeutics@Portugal – OTP2021

8-9 July 2021 | i3S, Porto, Portugal

 

The First Symposium on Oligonucleotide Technologies and Therapeutics in Portugal (OTP2020) has been organized and was expected to take place in Porto at i3S, in December 2020. Due to the uncertainty caused by the COVID-19 situation, the organizing committee has decided to postpone this first event to July 2021. 

 

 

The first Symposium on Oligonucleotide Technologies and Therapeutics in Portugal (OTP2021) wants to bring together national and international scientists from academia and industry, as well as the medical community, interested in nucleic-acids-based technologies and therapeutics. We expect to cover a wide range of topics in different sessions dedicated to:

I- Nucleic Acids Chemistry, Structures and Technologies
II- Delivery and Targeting
III- Discovery and Development (pre-clinical and clinical)

We aim to contribute to the creation of a network and forum by gathering national young and established scientists in the country, both from academia and industry, together with leading international guest speakers. We encourage you to take this opportunity to discuss your research and to submit your abstract for oral or poster presentation.

Venue

The meeting will be held at i3S - Instituto de Investigação e Inovação em Saúde, University of Porto

Rua Alfredo Allen, 208; 4200-135 Porto, Portugal
Tel: +351 220 408 800 | Site: http://www.i3s.up.pt/ | E-mail: events@i3s.up.pt
GPS coordinates: 41º 10' 30.008'' N, 8º 36' 12.488'' W.

 


 

Travel Information

 

A. Arriving at Porto by train
Take the train to Campanhã train station or São Bento train station. Metro or buses are available from both stations to the venue. However, the metro is the easiest way to reach i3S.

From Campanhã train station:
Metro: All lines are possible (A, B, C, E, and F) | Destination Station: Trindade and then change to line D – yellow (destination Hospital São João) – and leave at the station: Pólo Universitário | Average time: 16 minutes | For more information:http://www.metrodoporto.pt/en/. Obs: when changing to line D you need to re-validate your ticket again.

From São Bento train station:
Metro: Line D – yellow | Destination Station: Hospital São João; leave at the station: Pólo Universitário (no connections – direct line) | Average time: 10 minutes | For more information: http://www.metrodoporto.pt/en/

 

B. Arriving at Porto by car
The i3S Institute – GPS coordinates are: 41º 10′ 30.008” N, 8º 36′ 12.488” W.
Please note that i3S does not offer parking space.

Organization

Organizing Committee
Pedro Moreno (INEB/i3S)
Sofia Santos (INEB/i3S)
Nuno Azevedo (FEUP, LEPABE)
Rita Sobral Santos (FEUP, LEPABE)
Nuno Guimarães (FEUP, LEPABE)
Sandra Alves (Instituto Nacional de Saúde Dr. Ricardo Jorge/CECA-ICETA)
Liliana Matos (Instituto Nacional de Saúde Dr. Ricardo Jorge/CECA-ICETA)
Daniel Vasconcelos (Imperial College London/MiNA Therapeutics, UK)

 

Scientific Committee
Pedro Moreno (INEB/i3S)
Sofia Santos (INEB/i3S)
Ana P. Pêgo (INEB/i3S)
Nuno Azevedo (FEUP, LEPABE)
Rita Sobral Santos (FEUP, LEPABE)
Nuno Guimarães (FEUP, LEPABE)
Sandra Alves (Instituto Nacional de Saúde Dr. Ricardo Jorge/CECA-ICETA)
Liliana Matos (Instituto Nacional de Saúde Dr. Ricardo Jorge/CECA-ICETA)
Daniel Vasconcelos (Imperial College London/MiNA Therapeutics, UK)
Bruno Godinho (UMass, RNA Institute, USA)

 

Program

DAY 1 - 8 July 2021

Preliminary program (confirmed speakers and general theme of the talk)

 

This two-day meeting will be organized in 3 sessions

MORNING

Session I – Nucleic acids chemistry, structures and technologies
Synthesis and modifications of nucleoside, nucleotides and oligonucleotides; conjugates; DNA/RNA nanotechnology; aptamers; sensors/diagnostics.

 

Confirmed Speakers 

Muthiah Manoharan, Alnylam Pharmaceuticals, USA
(Living in the World of RNAi Therapeutics: A Triumph of Biomimetic Chemistry)

Nuno M. Xavier, Univ. Lisboa, PT
(Medicinal chemistry of nucleosides/nucleotides)

Carina Almeida, INIAV, PT
(Aptamers for toxin detection)

Marcel Hollenstein, Institut Pasteur, FR
(Chemically modified nucleoside analogs in functional nucleic acids)

Jorgen Kjems, iNANO, Arrhus University, DK
(Chemically modified nucleoside analogs in functional nucleic acids)

 

AFTERNOON

Session II – Delivery and Targeting
Mammalian and bacterial cell uptake; nanoparticle-based delivery; conjugate-based delivery; tissue targeting; intracellular trafficking.

Stefaan De Smedt, UGent, BE
(Intracellular delivery of nucleic acids)

Ana P. Pêgo, i3S, UPorto, PT
(Polymeric and dendrimeric nucleic acids delivery systems)


Poster sessions (to be defined)

 

Dinner

 


DAY 2 - 9 July 2021

 

MORNING

Continuation, Session II – Delivery and Targeting

Steven Dowdy, Univ. California, San Diego School of Medicine, USA
(Delivery of macromolecular therapeutics / RNAi)

João Gonçalves, iMed-Univ.Lisboa, PT
(siRNA-nanobody conjugates for HIV infection)

 

Session III – Discovery and Development
Examples of existing and novel targets; preclinical and clinical applications of oligonucleotide therapeutics (e.g. siRNA, antisense ON, miRNA, anti-miRNA/antagomiRs, splice-switching oligos); animal models in oligo drug development; safety-toxicological considerations.

Brett P. Monia, IONIS Pharmaceuticals, USA
(antisense strategies to treat neurological diseases)
Sónia Silva, CEB , UMinho, PT
(antisense ONs against candida albicans)

 

AFTERNOON

Continuation, Session III – Discovery and Development

Luís Almeida, CNC, Univ.Coimbra, PT
(Antisense ONs for CNS disorders)

Aurélie Goyenvalle, University of Versailles, FR
(Antisense therapy for DMD and other neuromuscular disorders - Tricyclo-DNA ASO)

Lourdes Ruiz Desviat, Universidad Autónoma de Madrid, ES
(Antisense oligonucleotides use for Inborn Errors of Metabolism)

Teresa Coelho, Hospital Sto António, Centro Hospitalar do Porto, PT
(Oligonucleotide-based drugs for ATTR amyloidosis – clinical development)

 

Round Table (to be defined...)

 

Speakers

Confirmed speakers:

SESSION I - Nucleic Acids Chemistry, Structures and Technologies

Muthiah (Mano) Manoharan (Senior Vice President of Drug Innovation Chemistry, Scientific Advisory Board Member, and Distinguished Research Scientist at Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.)

Marcel Hollenstein (Coordinator of Bioorganic Chemistry of Nucleic Acids Group, Institut Pasteur, Paris, France)

Nuno M. Xavier (Assistant Researcher at Centro de Química Estrutural (CQE), Faculty of Sciences, University of Lisbon (FCUL), Portugal)

Carina Almeida (Associate Researcher of the National Institute of Agrarian and Veterinary Research (INIAV), Portugal. Co-founder of Biomode S.A.)

Jorgen Kjems (Professor, Interdisciplinary Nanoscience Centre (iNANO), Department of Molecular Biology and Genetics, Aarhus University, Denmark)

 

SESSION II - Delivery and Targeting

Steven F. Dowdy (Professor, Univ. of California San Diego, School of Medicine, USA. Board member of Oligonucleotide Therapeutics Society)

Stefaan De Smedt (Professor, University of Ghent, Belgium. Pro-dean of the faculty of Pharmaceutical Sciences, Director of Ghent Research Group on Nanomedicines, Director of Laboratory of General Biochemistry and Physical Pharmacy)

Ana P. Pêgo (Coordinator of the nBTT - nanoBiomaterials for Targeted Therapies Group at i3S - Instituto de investigação e Inovação em Saúde, Universidade do Porto, Portugal)

João Gonçalves (Head of the Biopharmaceutical and Molecular Biotechnology Unit at the iMed-Research Institute for Medicines and Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon, Portugal.

 

SESSION III - Discovery and Development

Brett P. Monia (CEO, IONIS Pharmaceuticals, USA)

Luís Almeida (Assistant Professor at Faculty of Pharmacy, University of Coimbra and Principal Investigator and head of Molecular Therapy of Brain Disorders group at CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.)

Aurélie Goyenvalle (Group Leader in the Unit of Therapies for Neuromuscular Diseases at Université de Versailles St- Quentin U1179 INSERM, France)

Lourdes Ruiz Desviat (Associate Professor at the Department of Molecular Biology, University Autonoma of Madrid; Director of the research institute “Centro de Biología Molecular Severo Ochoa”, Madrid, Spain. Group leader in the research line “Physiopathology studies and therapeutical approaches in animal and cellular models of neurometabolic diseases”.)

Sónia Silva (Assistant Researcher at the Biofilm Research Lab, Dept. Biological Engineering, Univ. Minho, Braga)

Teresa Coelho (Neurologist and Neurophysiologist, Andrade’s Unit for Familial Amyloidosis, Santo Antonio Hospital, Centro Hospitalar Universitário do Porto)

 

Abstract Submission

Abstract submission opening will be announced SOON. 

Authors are invited to submit abstracts to either poster or oral communication. Among abstracts submitted for oral presentation (12 min + 3 min discussion) the Scientific Committee will make a selection to be included in the main program. The remaining abstracts should be prepared as posters for the poster viewing session.

 

Abstracts should be structured according to the template, under the headings below:

Title
Title should be in bold Times New Roman font (font size: 14; 1pt spacing between lines).

Authors
Type initials and surnames of the authors (Times New Roman; font size:12; centred; 1pt spacing between lines). Underline the name of the presenting author. Include superscripted letters by alphabetical order referring to the affiliations.

Affiliation
This should include the name of department or laboratory, followed by the name of the organisation (university/company), city and country (Times New Roman; font size:10; justified; 1pt spacing between lines and 6pt spacing between paragraphs). One affiliation per line.

Abstract body
This should be in Times New Roman font (font size: 12; justified; 1pt spacing between lines and 6pt spacing between paragraphs). Abstract must be structured as: introduction, materials and methods, results, conclusions.

Graphs and tables are optional.

References (if necessary)
Along the text the references should be numbered and in between square brackets. In the references list they should be in Times New Roman font (font size: 11; justified; 1pt spacing between lines) and in Vancouver style.

Acknowledgements (if necessary)
This should be in Times New Roman font (font size: 11; justified; 1pt spacing between lines). Include the title in bold.

Additional Rules
The margins should be set to Normal (sup.: 2,5cm; Inf.: 2.5cm; Left.: 3cm; Right.: 3cm). Abstract length is limited to one page A4, including tables and graphs, and all of the topics above.

 

Registration

Registration opening will be announced SOON. 
Limited to 135 participants (first come first serve basis)

 

Fees:
Registration fee includes coffee breaks, lunches and symposium material.

- Undergraduate, MSc, PhD Student: 85€
- Academia/Clinicians: 125€
- Industry/Non-Academia: 250€

Registration for social event/dinner: 25€ (book early as availability is limited)

Accommodation

Eurostars Oporto****
R. Mte. Guilherme Camarinha 212, 4200-537 Porto
https://www.eurostarshotels.com.pt/eurostars-oporto.html

 

Hotel Ibis Porto Sao Joao**
R. Dr. Plácido da Costa, 4200-450 Porto
An agreement is in place between IBIS and OTP organization offering the following conditions:
Individual Room (1 double bed) with breakfast (taxes included) – 64.20 €/noite
Double Room (2 single beds) with breakfast (taxes included) – 73.40 €/noite
Triple Room (3 single beds) with breakfast (taxes included) – 97.60 €/noite
Use the below link to book with the special prices:
mailto:h3227@accor.com?subject=Evento 1st Symposium on Oligonucleotide Technologies and Therapeutics 3 a 04-12-2020

 

Porto City Hotel ***
Rua de Faria Guimarães 211-215, União de Freguesias do Centro, 4000-206 Porto
Close to Subway Station “Faria Guimarães”

 

Hotel Tryp Porto Centro***
Rua da Alegria 685, Bonfim, 4000-046 Porto
Close to Subway Station “Marquês”

Sponsors

CO-ORGANIZED BY: 

 


SUPPORTED BY:

  

European Union’s Horizon 2020 research and innovation programme under grant agreement No 810685


Sponsors are still welcomed
Contact: pedro.moreno@ineb.up.pt


Events Management Unit | Rua Alfredo Allen 208 | 4200-135 Porto, Portugal
Email: events@i3s.up.pt | Tel: +351 220 408 800