creating a
healthier future

2nd General Meeting ADHER´N RISE CA18240

NEW DATES: 15-16 July 2021

Due to the SARS-CoV-2/COVID-19 pandemic situation, an on-site meeting cannot take place. Therefore, an online version of the meeting will take place.



The Action aims to promote, stimulate and translate research on Adhesion-G protein-coupled receptors (aGPCRs) ‘from bench to bedside’ in Europe. Adhesion-GPCRs are a class of structurally and functionally highly intriguing cell surface receptors with essential functions in health and disease, which have remained understudied for a long time and thus, display a vastly unexploited pharmacological potential. Only the past years have seen an increase in efforts to unravel the mysteries of this enigmatic family of GPCRs. Scientists, as well as clinicians from different fields with divergent expertise and interests, begin to recognise the relevance of aGPCRs and get involved in aspects of aGPCR research. As a consequence, the community is young, only just forming and not well organised.

The Second General Meeting wants to bring together the COST Action community and foster a network of dedicated non-tenured Early Career Investigators (ECIs), clinicians and representatives of pharmaceutical companies, provide communication platforms and opportunities to interact.

We expect to cover a wide range of topics in different sessions dedicated to:
I - Structure-function relation
II- Physiology and clinical relevance
III- Innovation and technology development
IV - Sequence repertoire and evolution of Ahesion GPCRs 

We encourage you to take this opportunity to discuss your research and to submit your abstract for oral or poster presentation.




Local Organiser
André Maia (Local organizer)
Head of Scientific Platform
BioSciences Screening, i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal


Scientific Committee
André Maia, i3S
Simone Promel 
Ines Liebscher
Katja Spiess
Biljana Stankovic
Jan Weber
Katarina Trajkovic





Day 1 (Thursday, July 15th) 

8:45 (PT)/09:45 (CET) – 09:00 (PT)/10:00 (CET)  Welcome from Dr. Andre Maia (local organiser, MC Representative, WG4 leader) and Prof. Ines Liebscher (Scientific Representative ADHER’N RISE) and Prof. Simone Promel (Chair ADHER’N RISE).


SESSION I - Technical Advances in aGPCR reserach
Chairs: Mark Soave & Caroline Wilde

9:00 (PT)/10:00 (CET) - 09:45 (PT)/10:45 (CET) - Keynote talk: Challenges and solutions to disentangle adhesion GPCR functions 
Tobias Langenhan, Leipzig University, Germany

09:45 (PT)/10:45 (CET) - 10:00 (PT)/11:00 (CET) - Break 

10:00 (PT)/11:00 (CET) - 10:25 (PT)/11:25 (CET) - Selected talk: In silico drug repurposing of small organic molecules and peptide ligands for GPR56 receptor
Milan Sencanski

10:25 (PT)/11:25 (CET) - 10:50 (PT)/11:50 (CET) - Selected talk: GPCRomics of Homeostatic and Disease-Associated Human Microglia
Cheng-Chih Hsiao

10:50 (PT)/11:50 (CET) - 11:05 (PT)/12:05 (CET) - Break 

11:05 (PT)/12:05 (CET) - 11:30 (PT)/12:30 (CET) -  Selected talk: Quantitative assessment of constitutive G protein-coupled receptor activity with BRET-based G protein biosensors
Hannes Schihada

11:30 (PT)/12:30 (CET) - 13:00 (PT)/14:00 (CET) - Lunch break 


SESSION II - Physiology of aGPCR
Chair: Katja Spiess & Maja Nybo

13:00 (PT)/14:00 (CET) - 13:45 (PT)/14:45 (CET)  -  Keynote talk: Building bodies: Adhesion-GPCRs at the front, back and sides
Caroline Formstone, King´s College London, UK

13:45 (PT)/14:45 (CET) - 14:00 (PT)/15:00 (CET) - Break 

14:00 (PT)/15:00 - 14:25 (PT)/15:25 (CET) - Selected talk: Adgra3 required for male fertility through regulations of fluid reabsorption and calcium/phosphate homeostasis
Maja Lind Nybo 

14:25 (PT)/15:25 (CET) - 14:50 (PT)/15:50 (CET) - Selected talk: Unravelling the role of adhesion G-protein-coupled receptor Gpr126 signalling in the blood-brain barrier
Monica Giannotta 

14:50(PT)/15:50 (CET) - 15:15 (PT)/16:15 (CET) - Selected talk: Characterisation of CG15744 (remoulade), a novel adhesion GPCR in Drosophila melanogaster
Genevieve Auger

15:15 (PT)/16:15 (CET) - 15:30 (PT)/16:30 (CET) - Break

15:30 (PT)/16:30 (CET) - 15:55 (PT)/16:55 (CET) - Selected talk: The non-autonomous role of the adhesion GPCR Mayo/CG11318 in the ion regulation of larval hemolymph of Drosophila melanogaster
Fernando Contreras

15:55 (PT)/16:55 (CET) - 16:20 (PT)/17:20 (CET) - Selected talk: Mumps virus exploitation of adhesion G protein-coupled receptor ADGRA3 (GPR125)
Katja Spiess 

16:20 (PT)/17:20 (CET) - 17:00 (PT)/18:00 (CET) - Break

17:00 (PT)/18:00 (CET) - 18:00 (PT)/19:00 (CET) - Poster session


Day 2 (Friday, July 16th) 


SESSION III - Networking within and outside the COST Action

9:00 (PT)/10:00 (CET) – 11:00 (PT)/12:00 (CET)  -  Workgroup meetings

WG 1: Biljana Stankovic
WG 2: Ines Liebscher
WG 3: Jan Weber
WG 4: André Maia
WG 5: Ana Rotter

11:00 (PT)/12:00 (CET) – 11:30 (PT)/12:30 (CET) -  Workgroup meetings wrap-up & announcements

11:30 (PT)/12:30 (CET) - 12:30 (PT)/13:30 (CET) - Invited talk: Dr. GPCR: how to marry GPCRs, communication and entrepreneurship
Yamina Berchiche, Dr GPCR, Boston, USA

12.30 (PT)/13:30 (CET) – 13:00 (PT)/14:00 (CET) - Lunch

13:00 (PT)/14:00 (CET) – 14:50 (PT)/15:50 (CET) - MC Meeting (by invitation only)


SESSION IV - Insights in structure and function of aGPCR
Chairs: Amal Hassan & Tanya Whitfield

15:00 (PT)/16:00 (CET) - 15:45 (PT)/16:45 (CET)  -  Keynote talk: A molecular understanding for the activation of adhesion GPCR transmembrane region
Demet Arac, University of Chicago, USA

15:45 (PT)/16:45 (CET) - 16:00 (PT)/17:00 (CET) - Break

16:00 (PT)/17:00 (CET) - 16:25 (PT)/17:25 (CET) - Selected talk: Homology modeling of GPR114/ADGRG5 with Rosetta elucidates possible interactions between ECL2 and GAIN Domain
Fabian Liessmann 

16:25 (PT)/17:25 (CET) - 16:50 (PT)/17:50 (CET) - Selected talk: Phenotypic screening in zebrafish larvae reveals candidate modulators of the adhesion GPCR Adgrg6 (Gpr126)
Ansar Azad 

16:50 (PT)/17:50 (CET) - 17:05 (PT)/18:05 (CET) - Break

17:05 (PT)/18:05 (CET) - 17:30 (PT)/18:30 (CET) -  Selected talk: Defining the mechanical forces needed to activate the adhesion G protein-coupled receptor GPR126/ADGRG6
Jakob Mitgau

17:30 (PT)/18:30 (CET) - 17:35 (PT)/18:35 (CET) - Closing Remarks

Abstract Submission

Instructions for abstract format and layout:
– The entire abstract must fit one single A4 page, including title, authors and affiliations.
– The abstract body may have a maximum of 2500 characters with spaces for text plus references, size-11 font.
– No figures or schematics are allowed.
– Authors should follow the abstract layout provided here.

Abstract Submission deadline: 13th June 2021


Registration is free but mandatory.

Due to the SARS-CoV-2/COVID-19 pandemic situation an on-site meeting cannot take place. Therefore, an on-line version of the meeting will take place.


Registration deadline has been extended.





More information
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