Open Session of the

Neurobiology and Neurologic Disorders Integrative Program

14:30-17:30 | 20 September 2018

Auditório da Fundação Serralves, Porto

Dear colleagues,

It is a pleasure to announce the 1st Retreat of the Neurobiology and Neurologic Disorders Integrative Program. This inaugural event will take place on the 20th September 2018 at Fundação de Serralves.

The morning session and lunch are for all members of the Neurobiology and Neurologic Disorders Integrative Program and invited guests. During this session, we will have a few selected talks and the meeting of the group leaders from our integrative program.

In the afternoon, we will have a mini-symposium, which will be open to the entire i3S community, followed by a “Porto de Honra. In the mini-symposium, we will have presentations by Jue Chen (Rockefeller University, Howard Hughes Medical Institute), Ana Luisa Carvalho (CNC, Universidade de Coimbra) and Roderick MacKinnon (Rockefeller University, Howard Hughes Medical Institute).

Jue Chen research aims at revealing the structural and mechanistic insights of ATP-binding cassette (ABC) transporters. These ubiquitous membrane proteins participate in the import or export of molecules across cellular membranes. With significant medical and basic biology relevance, Chen’s research aims at understanding how anti-cancer drugs are ejected by ABC transporters, how CFTR’s unique channel function is regulated and how antigens are transported and loaded onto MHC-I molecules.

Ana Carvalho research aims at understating cellular and molecular mechanisms of synaptic function and plasticity. Understanding the mechanisms that regulate and modulate neuronal synaptic communication has great relevance to our understanding of memory and behavior. In addition, Carvalho’s research also aims at elucidating how synaptic dysfunction underlies neuropsychiatric and neurodegenerative disorders.

Roderick MacKinnon received the 2003 Nobel Prize in Chemistry for structural and mechanistic studies of ion channels. Mackinnon research aims at understanding the principles underlying biological electricity, and how the passage of ions across cell membranes is regulated. More recently, his group has also begun to study how mechanical forces elicit electrical signals, which underlies a wide variety of physiologic processes from sensory detection to cell volume regulation.

We hope that you will be able to join us and enjoy our first retreat

The organizers,

Pedro Brites |  Teresa Summavielle

Chair - João Cabral, i3S, IBMC

14:30     ABC transporters, molecular pumps powered by ATP

Jue Chen, Rockefeller University, Howard Hughes Medical Institute, USA

15:30     Synaptic dysfunction in neuropsychiatric disorders

Ana Luisa Carvalho, University of Coimbra, CNC, Portugal

16:30     Ion channels in cell signaling

Roderick MacKinnon, Rockefeller University, Howard Hughes Medical Institute, USA

REGISTRATION

Registration is free, but mandatory until 17th September.

MORE INFORMATION:

Events Management Unit | Rua Alfredo Allen 208 | 4200-135 Porto, Portugal

Email: events@i3s.up.pt | Tel: +351 220 408 811