Where Ideas Grow
Joana Teixeira
Junior Researcher

I am a postdoctoral researcher at the Instituto de Investigação e Inovação em Saúde of the University of Porto. My research interests lie in understanding the molecular mechanisms underlying diseases associated with non-coding traits. Using a combination of genome editing, cell biology, and bioinformatic tools, I aim to elucidate the role of non-coding DNA sequences in the cis-regulation process and their contribution to human diseases. In 2022, I completed my PhD in Molecular and Cell Biology at the University of Porto. During my PhD, I investigated the impact of disrupting pancreatic cis-regulatory elements (CREs) on the development of pancreatic cancer (PC). By analyzing histone modifications, transcription, chromatin accessibility, and interactions, I identified zebrafish pancreas CREs and their human functional equivalents. This work led to the discovery of disease-associated sequences across species, including potential PC-associated CREs. Our findings were published in the prestigious journal Nature Communications (IF=17.7, Q1), and I presented them at four oral communications in national and international conferences. Throughout my academic career, I have contributed to several publications as a first author, including those in Current Pharmacogenomics and Personalized Medicine, Environmental Microbiology Reports (IF=3.5, Q1), and Medical Microbiology and Immunology (IF=3.2, Q1). Additionally, I have co-authored papers in Cell Reports (IF=9.4, Q1), European Journal of Public Health (IF=2.2, Q1), and Pediatric Infectious Disease Journal (IF=2.3, Q1). Currently, I am co-supervising a PhD student and a Master student, and in 2021, I co-supervised a BSc Erasmus student.