Where Ideas Grow
Rita F Santos
Junior Researcher

Rita F Santos graduated in Biomedical Sciences from the Polytechnic Institute of Porto in 2012 and then got a master degree in Molecular and Cellular Biology at the University of Aveiro. Rita developed her master thesis at the IBMC under the supervision of Alexandre Carmo. Her main interest in investigating the features that regulate the immune response lead her to pursue her studies in the field and enroll in the Ph.D. program in Molecular and Cellular Biology from ICBAS. During the Ph.D., Rita dissected the functional role of the T cell surface protein CD6 in the regulation of T cell activation with a special interest in the importance of this molecule during the course of an autoimmune disease. After finishing her Ph.D., in September of 2020, Rita joined the Stem Cells in Regenerative Biology and Repair group, led by Prof. Perpétua Pinto-do-Ó, at INEB in order to study the mechanisms behind the hematopoiesis process.

Selected Publications

Santos R.F., Oliveira L., Brown M.H., Carmo A.M.,
Domain-specific CD6 monoclonal antibodies identify CD6 isoforms generated by alternative-splicing. Immunology157(4):296-303, 2019. [Journal: Article] [CI: 4] [IF: 5]
DOI: 10.1111/imm.13087 SCOPUS: 85068083912.

Freitas R.F., Basto A., Almeida S.C.P., Santos R.F., Gonçalves C.M., Corria-Osorio J., Carvalho T., Carmo A.M., Oliveira V.G., Leon K., Graca L.,
Modulation of CD4 T cell function via CD6-targeting. EBioMedicine47:427-435, 2019. [Journal: Article] [CI: 4] [IF: 5,7]
DOI: 10.1016/j.ebiom.2019.08.008 SCOPUS: 85072256661.

Gonçalves C.M., Henriques S.N., Santos R.F., Carmo A.M.,
CD6, a rheostat-type signalosome that tunes T cell activation. Frontiers in Immunology9:, 2018. [Journal: Review] [CI: 10] [IF: 4,7]
DOI: 10.3389/fimmu.2018.02994 SCOPUS: 85059925855.

Pereira C.B., Bocková M., Santos R.F., Santos A.M., de Araújo M.M., Oliveira L., Homola J., Carmo A.M.,
The scavenger receptor SSc5D physically interacts with bacteria through the SRCR-containing N-terminal domain. Frontiers in Immunology7(OCT):, 2016. [Journal: Article] [CI: 12] [IF: 6,4]
DOI: 10.3389/fimmu.2016.00416 SCOPUS: 84997514499.

Santos R.F., Oliveira L., Carmo A.M.,
Tuning T cell activation: The function of CD6 at the immunological synapse and in T cell responses. Current Drug Targets17(6):630-639, 2016. [Journal: Article] [CI: 29] [IF: 3,2]
DOI: 10.2174/1389450116666150531152439 SCOPUS: 84964055216.

Brisslert M., Bian L., Svensson M.N.D., Santos R.F., Jonsson I.M., Barsukov I., Erlandsson M., Andersson K., Carmo A.M., Bokarewa M.I.,
S100A4 regulates the Src-tyrosine kinase dependent differentiation of Th17 cells in rheumatoid arthritis. Biochimica et Biophysica Acta - Molecular Basis of Disease1842(11):2049-2059, 2014. [Journal: Article] [CI: 7] [IF: 4,9]
DOI: 10.1016/j.bbadis.2014.07.003 SCOPUS: 84907983758.