Where Ideas Grow
Sara Ricardo
Visiting Scientists

Sara Ricardo completed the PhD degree in molecular pathology and genetics in 2011/09/08 by Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar. She has a solid background in the pathology field, working in the diagnostic pathology lab of Ipatimup for the first 10 years of her career. During this time, she developed the Msc and PhD degree as a researcher in the Breast Pathology field. After completion the PhD degree, she started working as a post-doc researcher in the Differentiation and Cancer group at i3s/ipatimup and shifted from breast to ovary cancer research, maintaining the scientific area in the gynaecological oncology field.

The major significant reseach outputs in ovarian cancer research are: (1) Defenition of glyco‐mucin profiles with higher specificity level than CA125 assay (DOI:10.1016/j.molonc.2014.10.005); (2) First design of a MUC16 TR vaccine construct and production of a MUC16 mAb (DOI: 10.1093/glycob/cwv056); (3) Mucin and truncated O-glycan footprint of the majoraty ovarian cancer cell lines of serous origin do not reflect the phenotype of serous ovarian carcinomas (DOI: 10.3390/ijms19072045); (4) Defenition of mesothelin is a key player in peritoneal dissemination (DOI: 10.1038/s41389-020-00246-2); (5) Generation of two high-grade serous carcinoma cell lines, with a double-chemoresistant (Carboplatin and Paclitaxel) phenotype (DOI: 10.3389/fonc.2021.752127).

In 2017, Sara Ricardo started her path as independent researcher but she her trajectory in ovarian research field started in 2012, during her postdoctoral training, setting an important footprint in ovarian cancer molecular pathology, defining, for the first time, a glyco-mucin profile that identifies malignant ovarian tumors with higher specificity than CA125 alone. She is now recognised an expert in molecular pathology of ovarian tumors, participating as evaluator in national and European research projects calls (e.g. ERC grants) and as reviewer of high impact journal (e.g. Nature Communications, Frontiers Oncology, Cancers). Recently she was awarder, as supervisor, two PhD fellowships from FCT (Ref. 2021.05081.BD; Ref. 2020.04720.BD), co-coordinates a FCT project since 2017 (PTDC/MEC-ONC/29503/2017) and is a PI of a research project since 2018 (HOPE, OC Patient donative). She has been involved as supervisor of many graduated/undergraduate students and jury member of several academic thesis/dissertations. Besides her position as a researcher, Sara Ricardo is an assistant professor at IUCS-CESPU, coordinating the Biopathology curricular unit, professor of histology and biomedical investigation, and member the committee of biomedical sciences Bsc and PhD degrees. She integrates a national commission for the assessment and accreditation of higher education courses at A3ES. She has authored or co-authored 33 publications in international peer-reviewed journals (H-index of 19).

Selected Publications

Nunes M., Duarte D., Vale N., Ricardo S.,
Pitavastatin and Ivermectin Enhance the Efficacy of Paclitaxel in Chemoresistant High-Grade Serous Carcinoma. Cancers14(18):, 2022. [Journal: Article] [CI: 6] [IF: 5,2]
DOI: 10.3390/cancers14184357 SCOPUS: 85138730639.


Nunes M., Silva P.M.A., Coelho R., Pinto C., Resende A., Bousbaa H., Almeida G.M., Ricardo S.,
Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein. Frontiers in Oncology11:, 2021. [Journal: Article] [CI: 9] [IF: 5,7]
DOI: 10.3389/fonc.2021.752127 SCOPUS: 85118608070.


Almeida-Nunes D.L., Mendes-Frias A., Silvestre R., Dinis-Oliveira R.J., Ricardo S.,
Immune Tumor Microenvironment in Ovarian Cancer Ascites. International Journal of Molecular Sciences23(18):, 2022. [Journal: Review] [CI: 9] [IF: 5,6]
DOI: 10.3390/ijms231810692 SCOPUS: 85138371537.


Nunes M., Pacheco F., Coelho R., Leitão D., Ricardo S., David L.,
Mesothelin Expression Is Not Associated with the Presence of Cancer Stem Cell Markers SOX2 and ALDH1 in Ovarian Cancer. International Journal of Molecular Sciences23(3):, 2022. [Journal: Article] [IF: 5,6]
DOI: 10.3390/ijms23031016 SCOPUS: 85122857215.


Coelho R., Ricardo S., Amaral A.L., Huang Y.L., Nunes M., Neves J.P., Mendes N., López M.N., Bartosch C., Ferreira V., Portugal R., Lopes J.M., Almeida R., Heinzelmann-Schwarz V., Jacob F., David L.,
Regulation of invasion and peritoneal dissemination of ovarian cancer by mesothelin manipulation. Oncogenesis9(6):, 2020. [Journal: Article] [CI: 27] [IF: 7,5]
DOI: 10.1038/s41389-020-00246-2 SCOPUS: 85087314253.


Nunes M., Abreu M.H., Bartosch C., Ricardo S.,
Recycling the purpose of old drugs to treat ovarian cancer. International Journal of Molecular Sciences21(20):1-24, 2020. [Journal: Review] [CI: 12] [IF: 5,9]
DOI: 10.3390/ijms21207768 SCOPUS: 85093658021.


Coelho R., Marcos-Silva L., Mendes N., Pereira D., Brito C., Jacob F., Steentoft C., Mandel U., Clausen H., David L., Ricardo S.,
Mucins and truncated O-glycans unveil phenotypic discrepancies between serous ovarian cancer cell lines and primary tumours. International Journal of Molecular Sciences19(7):, 2018. [Journal: Article] [CI: 22] [IF: 4,2]
DOI: 10.3390/ijms19072045 SCOPUS: 85050135212.


Coelho R., Marcos-Silva L., Ricardo S., Ponte F., Costa A., Lopes J.M., David L.,
Peritoneal dissemination of ovarian cancer: Role of MUC16-mesothelin interaction and implications for treatment. Expert Review of Anticancer Therapy18(2):177-186, 2018. [Journal: Review] [CI: 27] [IF: 2,6]
DOI: 10.1080/14737140.2018.1418326 SCOPUS: 85043386275.


Ricardo S., Marcos-Silva L., David L.,
Mucin carriers of TF in ovarian cancer. Journal of Cancer Research and Clinical Oncology142(8):1867-1868, 2016. [Journal: Letter] [CI: 1] [IF: 3,5]
DOI: 10.1007/s00432-016-2186-4 SCOPUS: 84976333418.


Ricardo S., Marcos-Silva L., Valente C., Coelho R., Gomes R., David L.,
Mucins MUC16 and MUC1 are major carriers of SLea and SLex in borderline and malignant serous ovarian tumors. Virchows Archiv468(6):715-722, 2016. [Journal: Article] [CI: 16] [IF: 2,8]
DOI: 10.1007/s00428-016-1929-6 SCOPUS: 84961842101.


Marcos-Silva L., Ricardo S., Chen K., Blixt O., Arigi E., Pereira D., Høgdall E., Mandel U., Bennett E.P., Vakhrushev S.Y., David L., Clausen H.,
A novel monoclonal antibody to a defined peptide epitope in MUC16. Glycobiology25(11):1172-1182, 2015. [Journal: Article] [CI: 13] [IF: 3,3]
DOI: 10.1093/glycob/cwv056 SCOPUS: 84946146517.


Ricardo S., Marcos-Silva L., Pereira D., Pinto R., Almeida R., Söderberg O., Mandel U., Clausen H., Felix A., Lunet N., David L.,
Detection of glyco-mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours. Molecular Oncology9(2):503-512, 2015. [Journal: Article] [CI: 51] [IF: 5,4]
DOI: 10.1016/j.molonc.2014.10.005 SCOPUS: 84921309842.