Where Ideas grow
Jaime Freitas
Research Scientist

Jaime Freitas completed his PhD at Wageningen University and Research (The Netherlands) and the University of California-Davis (USA) on the development of assays to increase the insight into the mechanisms of toxic interference with the thyroid hormone (TH) receptors and provide a basis for the high-throughput screening of TH-like drugs. While finishing his PhD thesis, Jaime Freitas joined the EU-funded project NANOFOL at the IBMC (Portugal), with the aim of developing a nanodevice to target activated immune cells in Rheumatoid Arthritis. Due to his growing interest in the molecular mechanisms of RA, Jaime Freitas joined the Gene Regulation group at the IBMC (Portugal) and later moved to the University of Rutgers (USA), to learn how to use state-of-the-art bioinformatic tools to elucidate the role of transcription kinetics in essential RNA-processing mechanisms using custom sequencing methods. Currently, Jaime Freitas is a Junior Researcher in the Microenvironment in New Therapies group at i3S (Portugal) working in the translational-oriented R2Bone project, specifically, in non-coding RNA-based therapies for bone regeneration and inflammation in RA. 

Selected Publications

Brás J.P., Bravo J., Freitas J., Barbosa M.A., Santos S.G., Summavielle T., Almeida M.I.,
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity. Cell Death and Disease11(6):, 2020. [Journal: Article] [CI: 2] [IF: 6,3 (*)]
DOI: 10.1038/s41419-020-2626-6 SCOPUS: 85085909806.

Moura S.R., Bras J.P., Freitas J., Osório H., Barbosa M.A., Santos S.G., Almeida M.I.,
miR-99a in bone homeostasis: Regulating osteogenic lineage commitment and osteoclast differentiation. Bone134:, 2020. [Journal: Article] [CI: 3] [IF: 4,1 (*)]
DOI: 10.1016/j.bone.2020.115303 SCOPUS: 85080990375.

Plácido A., Bueno J., Barbosa E.A., Moreira D.C., Dias J.D.N., Cabral W.F., Albuquerque P., Bessa L.J., Freitas J., Kuckelhaus S.A.S., Lima F.C.D.A., Batagin-Neto A., Brand G.D., Relvas J.B., Leite J.R.S.A., Eaton P.,
The antioxidant peptide salamandrin-i: First bioactive peptide identified from skin secretion of salamandra genus (salamandra salamandra). Biomolecules10(4):, 2020. [Journal: Article] [CI: 1] [IF: 4,1 (*)]
DOI: 10.3390/biom10040512 SCOPUS: 85082731024.

Freitas J., Santos S.G., Gonçalves R.M., Teixeira J.H., Barbosa M.A., Almeida M.I.,
Genetically engineered-MSC therapies for non-unions, delayed unions and critical-size bone defects. International Journal of Molecular Sciences20(14):, 2019. [Journal: Article] [CI: 7] [IF: 4,6]
DOI: 10.3390/ijms20143430 SCOPUS: 85070503845.

Oliveira M.S., Freitas J., Pinto P.A.B., De Jesus A., Tavares J., Pinho M., Domingues R.G., Henriques T., Lopes C., Conde C., Sunkel C.E., Moreira A.,
Cell cycle kinase polo is controlled by a widespread 3=untranslated region regulatory sequence in Drosophila melanogaster. Molecular and Cellular Biology39(15):, 2019. [Journal: Article] [CI: 2] [IF: 3,6]
DOI: 10.1128/MCB.00581-18 SCOPUS: 85070024885.

Carvalho D.O., Freitas J., Nogueira P., Henriques S.N., Carmo A.M., Castro M.A., Guido L.F.,
Xanthohumol inhibits cell proliferation and induces apoptosis in human thyroid cells. Food and Chemical Toxicology121:450-457, 2018. [Journal: Article] [CI: 3] [IF: 3,8]
DOI: 10.1016/j.fct.2018.09.021 SCOPUS: 85054021358.

Braz S.O., Cruz A., Lobo A., Bravo J., Moreira-Ribeiro J., Pereira-Castro I., Freitas J., Relvas J.B., Summavielle T., Moreira A.,
Expression of Rac1 alternative 3' UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms1860(6):685-694, 2017. [Journal: Article] [CI: 2] [IF: 5,2]
DOI: 10.1016/j.bbagrm.2017.03.002 SCOPUS: 85018940086.

Liu X., Freitas J., Zheng D., Oliveira M.S., Hoque M., Martins T., Henriques T., Tian B., Moreira A.,
Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster. RNA23(12):1807-1816, 2017. [Journal: Article] [CI: 23] [IF: 4,5]
DOI: 10.1261/rna.062661.117 SCOPUS: 85034084061.

Nogueira E., Freitas J., Loureiro A., Nogueira P., Gomes A.C., Preto A., Carmo A.M., Moreira A., Cavaco-Paulo A.,
Neutral PEGylated liposomal formulation for efficient folate-mediated delivery of MCL1 siRNA to activated macrophages. Colloids and Surfaces B: Biointerfaces155:459-465, 2017. [Journal: Article] [CI: 12] [IF: 4]
DOI: 10.1016/j.colsurfb.2017.04.023 SCOPUS: 85019046361.

Nogueira E., Cruz C.F., Loureiro A., Nogueira P., Freitas J., Moreira A., Carmo A.M., Gomes A.C., Preto A., Cavaco-Paulo A.,
Assessment of liposome disruption to quantify drug delivery in vitro. Biochimica et Biophysica Acta - Biomembranes1858(2):163-167, 2016. [Journal: Article] [CI: 4] [IF: 3,5]
DOI: 10.1016/j.bbamem.2015.11.008 SCOPUS: 84948166510.

Nogueira E., Mangialavori I.C., Loureiro A., Azoia N.G., Sárria M.P., Nogueira P., Freitas J., Härmark J., Shimanovich U., Rollett A., Lacroix G., Bernardes G.J.L., Guebitz G., Hebert H., Moreira A., Carmo A.M., Rossi J.P.F.C., Gomes A.C., Preto A., Cavaco-Paulo A.,
Peptide Anchor for Folate-Targeted Liposomal Delivery. Biomacromolecules16(9):2904-2910, 2015. [Journal: Article] [CI: 29] [IF: 5,6]
DOI: 10.1021/acs.biomac.5b00823 SCOPUS: 84941584525.

Nogueira E., Lager F., Le Roux D., Nogueira P., Freitas J., Charvet C., Renault G., Loureiro A., Almeida C.R., Ohradanova-Repic A., Machacek C., Bernardes G.J.L., Moreira A., Stockinger H., Burnet M., Carmo A.M., Gomes A.C., Preto A., Bismuth G., Cavaco-Paulo A.,
Enhancing methotrexate tolerance with folate tagged liposomes in arthritic mice. Journal of Biomedical Nanotechnology11(12):2243-2252, 2015. [Journal: Article] [CI: 38] [IF: 3,9]
DOI: 10.1166/jbn.2015.2170 SCOPUS: 84941551653.

Nogueira E., Loureiro A., Nogueira P., Freitas J., Almeida C.R., Härmark J., Hebert H., Moreira A., Carmo A.M., Preto A., Gomes A.C., Cavaco-Paulo A.,
Liposome and protein based stealth nanoparticles. Faraday Discussions166:417-429, 2013. [Journal: Review] [CI: 25] [IF: 4,2]
DOI: 10.1039/c3fd00057e SCOPUS: 84887481690.

Freitas J., Miller N., Mengeling B.J., Xia M., Huang R., Houck K., Rietjens I.M.C.M., Furlow J.D., Murk A.J.,
Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform. Current Chemical Genomics and Translational Medicine8(1):36-46, 2014. [Journal: Article] [CI: 17]
DOI: 10.2174/2213988501408010036 SCOPUS: 84989270930.

Gutleb A.C., Freitas J., Murk A.J., Verhaegen S., Ropstad E., Udelhoven T., Hoffmann L., Audinot J.N.,
NanoSIMS50 - A powerful tool to elucidate cellular localization of halogenated organic compounds. Analytical and Bioanalytical Chemistry404(9):2693-2698, 2012. [Journal: Article] [CI: 8] [IF: 3,7]
DOI: 10.1007/s00216-012-6066-8 SCOPUS: 84870927176.

Freitas J., Cano P., Craig-Veit C., Goodson M.L., David Furlow J., Murk A.J.,
Detection of thyroid hormone receptor disruptors by a novel stable in vitro reporter gene assay. Toxicology in Vitro25(1):257-266, 2011. [Journal: Article] [CI: 103] [IF: 2,8]
DOI: 10.1016/j.tiv.2010.08.013 SCOPUS: 78650522817.

Muller A., Freitas J., Silva E., Le Gall-Reculé G., Zwingelstein F., Abrantes J., Esteves P.J., Alves P.C., van der Loo W., Kolodziejek J., Nowotny N., Thompson G.,
Evolution of rabbit haemorrhagic disease virus (RHDV) in the European rabbit (Oryctolagus cuniculus) from the Iberian Peninsula. Veterinary Microbiology135(3-4):368-373, 2009. [Journal: Article] [CI: 43] [IF: 2,9]
DOI: 10.1016/j.vetmic.2008.09.057 SCOPUS: 62149127401.

van den Berg A., Freitas J., Keles F., Snoek M., van Marle J., Jansen H.M., Lutter R.,
Cytoskeletal architecture differentially controls post-transcriptional processing of IL-6 and IL-8 mRNA in airway epithelial-like cells. Experimental Cell Research312(9):1496-1506, 2006. [Journal: Article] [CI: 10] [IF: 3,8]
DOI: 10.1016/j.yexcr.2006.01.010 SCOPUS: 33646137375.