Where Ideas Grow
Helder Novais e Bastos
Clinical Affiliate Member

Helder Novais Bastos obtained a degree in Medicine in 2008, by Faculdade de Ciências Médicas da Universidade Nova de Lisboa (FCM-UNL), Portugal. He underwent undergraduate research in José Rueff’s lab, at Department of Genetics of FCM-UNL, from 2004 to 2008, where he carried-out an hospital-based case-control study to investigate the involvement of polymorphisms of several genes of the homologous recombination DNA repair pathway (XRCC3, XRCC2, NBS1 and RAD51) in thyroid cancer susceptibility. In 2009, he completed and passed the Post-graduate course in Travel Medicine (15 ECTS). The same year, he joined the School of Medicine and Life and Health Sciences Research Institute (ICVS) at University of Minho as an invited assistant and reseracher, respectively, having collaborated with several curricular units and activities of pregraduate and postgraduate curricular program. At ICVS, he was studying the cellular and molecular mechanisms involved in host-pathogen interaction during different stages of infection with Mycobacterium tuberculosis.

From 2010 to 2016, he underwent specialization in Pulmunology at Hospital São João, Porto. During his specialty training, he was also admitted to the PhD programme in Medicine at University of Minho, Portugal, having concluded and defended his PhD thesis in 2017.

Helder Novais Bastos was awarded with the following prizes and bursaries: Prize Thomé Villar Sociedade Portuguesa de Pneumologia (SPP) / Pfizer Vaccines 2017, Bursary D. Manuel de Mello 2013, Prize Robalo Cordeiro SPP 2012, 2015 and 2016 for his research projects; Prize SPP/Laboratórios Vitória 2013 and 2014 for the best portuguese oral presentation at the European Respiratory Conference; Bursary Young Specialists of Pneumology AstraZeneca / SPP 2012 for the best case report in obstructive airway diseases; and 1st Prize of Epidemiology of the X JOCEM (Jornadas Científicas de Estudantes de Medicina, 2008) for his work in genetic association studies in thyroid cancer risk.

He is an active member of European Respiratory Society (ERS) and Portuguese Pneumology Society (SPP).

In 2018, Helder Novais Bastos joined the Faculty of Medicine of University of Porto (FMUP) as invited Assistant Professor, and the i3S at Immune Regulation research group. He is currently a Pulmonologist at Hospital São João, where he works at interventional pulmonology and endoscopy sector, as well at the interstitial lung disease group and the thoracic oncology unit.

Selected Publications

Rodrigues I., Gomes R.E., Coutinho L.M., Rego M.T., Machado F., Morais A., Bastos H.N.,
Diagnostic yield and safety of transbronchial lung cryobiopsy and surgical lung biopsy in interstitial lung diseases: a systematic review and meta-analysis. European Respiratory Review31(166):, 2022. [Journal: Review] [CI: 9] [IF: 7,5]
DOI: 10.1183/16000617.0280-2021 SCOPUS: 85139272580.

Gonçales R.A., Bastos H.N., Duarte-Oliveira C., Antunes D., Sokhatska O., Jacob M., Rolo R., Campos C.F., Sasaki S.D., Donato A., Mapelli S.N., Costa S., Moura C.S., Delgado L., Morais A., Torrado E., van de Veerdonk F.L., Weichhart T., Lambris J.D., Silvestre R., Garlanda C., Mantovani A., Cunha C., Carvalho A.,
Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis. American Journal of Respiratory and Critical Care Medicine206(9):1140-1152, 2022. [Journal: Article] [CI: 5] [IF: 24,7]
DOI: 10.1164/rccm.202112-2771OC SCOPUS: 85139726848.

Sousa J., Cá B., Maceiras A.R., Simões-Costa L., Fonseca K.L., Fernandes A.I., Ramos A., Carvalho T., Barros L., Magalhães C., Chiner-Oms Á., Machado H., Veiga M.I., Singh A., Pereira R., Amorim A., Vieira J., Vieira C.P., Bhatt A., Rodrigues F., Rodrigues P.N.S., Gagneux S., Castro A.G., Guimarães J.T., Bastos H.N., Osório N.S., Comas I., Saraiva M.,
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1ß production. Nature Communications11(1):, 2020. [Journal: Article] [CI: 41] [IF: 14,9]
DOI: 10.1038/s41467-020-15832-6 SCOPUS: 85083842157.

Trovisco R., Freitas C., Serino M., Ferreira P., Martins B., Coelho D., Melo N., Fernandes G., Magalhães A., Bastos H.N.,
Predictors of lung entrapment in malignant pleural effusion. Pulmonology:, 2022. [Journal: Article] [CI: 1] [IF: 11,7]
DOI: 10.1016/j.pulmoe.2022.08.001 SCOPUS: 85138786045.

Costa M.I., Cipriano A., Santos F.V., Valdoleiros S.R., Furtado I., Machado A., Abreu M., Bastos H.N.,
Clinical profile and microbiological aetiology diagnosis in adult patients hospitalized with community-acquired pneumonia. Pulmonology28(5):358-367, 2022. [Journal: Article] [CI: 1] [IF: 11,7]
DOI: 10.1016/j.pulmoe.2020.11.003 SCOPUS: 85098653159.

Bastos H.N., Osório N.S., Gagneux S., Comas I., Saraiva M.,
The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflammation and clinical outcomes. Frontiers in Immunology8(JAN):, 2018. [Journal: Review] [CI: 17] [IF: 4,7]
DOI: 10.3389/fimmu.2017.01948 SCOPUS: 85042558392.

Bastos H.N., Osório N.S., Castro A.G., Ramos A., Carvalho T., Meira L., Araújo D., Almeida L., Boaventura R., Fragata P., Chaves C., Costa P., Portela M., Ferreira I., Magalhães S.P., Rodrigues F., Sarmento-Castro R., Duarte R., Guimarães J.T., Saraiva M.,
A prediction rule to stratify mortality risk of patients with pulmonary tuberculosis. PLoS ONE11(9):, 2016. [Journal: Article] [CI: 30] [IF: 2,8]
DOI: 10.1371/journal.pone.0162797 SCOPUS: 84992386220.