Where Ideas grow
Joana Caldeira
Project Leader

In 2005, Joana Caldeira graduated in Microbiology at the Biotechnology College of the Portuguese Catholic University and in 2011 got her PhD in Biomedicine (Faculty of Medicine of the University of Porto). After finishing university, she went to Centro Andaluz de Biologia del Desarrollo (Seville, Spain) where she worked as a research assistant for almost one year. She started her PhD thesis there, in a collaboration between Dr. Fernando Casares´ and Dr. Raquel Seruca's lab. During this period, Joana's main focus was oncobiology, using Drosophila as an animal model to study novel genes involved in Gastric Cancer. 

In 2012, she joined INEB in a collaboration between Prof. Mário Barbosa and her former supervisor Dr. Raquel Seruca. Since then, she has been interested in understanding the role of the extracellular matrix (both in cancer and in regeneration) and exploring the way it can be manipulated to recapitulate initial developmental stages, improving current regenerative therapies, namely of intervertebral disc disease. 

Joana has received funding from international agencies like EUROSPINE and ON Foundation, and has been honored with the L'Oréal Portugal Medal of Honor for Women in Science 2018. In 2020 she was awarded with the 1st prize of the EIT Jumpstarter, an european pre-accelerator business programme. Besides supervising national and international MSc and PhD theses she has participated in several science communication initiatives either as a mentor, project coordinator or collaborator. Currently, Joana is also the chair of the i3S Fundraising Team.

Selected Publications

Fiordalisi M., Silva A.J., Barbosa M., Gonçalves R., Caldeira J.,
Decellularized Scaffolds for Intervertebral Disc Regeneration. Trends in Biotechnology38(9):947-951, 2020. [Journal: Short Survey] [IF: 14,3 (*)]
DOI: 10.1016/j.tibtech.2020.05.002 SCOPUS: 85085290982.

Caldeira J., Santa C., Osório H., Molinos M., Manadas B., Goncalves R., Barbosa M.,
Matrisome Profiling during Intervertebral Disc Development and Ageing. Scientific Reports7(1):, 2017. [Journal: Article] [CI: 10] [IF: 4,1]
DOI: 10.1038/s41598-017-11960-0 SCOPUS: 85029508543.

Silva A.C., Rodrigues S.C., Caldeira J., Nunes A.M., Sampaio-Pinto V., Resende T.P., Oliveira M.J., Barbosa M.A., Thorsteinsdóttir S., Nascimento D.S., Pinto-do-Ó P.,
Three-dimensional scaffolds of fetal decellularized hearts exhibit enhanced potential to support cardiac cells in comparison to the adult. Biomaterials104:52-64, 2016. [Journal: Article] [CI: 21] [IF: 8,4]
DOI: 10.1016/j.biomaterials.2016.06.062 SCOPUS: 84978822623.

Pereira C.L., Teixeira G.Q., Ribeiro-Machado C., Caldeira J., Costa M., Figueiredo F., Fernandes R., Aguiar P., Grad S., Barbosa M.A., Goncalves R.M.,
Mesenchymal Stem/Stromal Cells seeded on cartilaginous endplates promote Intervertebral Disc Regeneration through Extracellular Matrix Remodeling. Scientific Reports6:, 2016. [Journal: Article] [CI: 24] [IF: 4,3]
DOI: 10.1038/srep33836 SCOPUS: 84988672665.

Molinos M., Almeida C.R., Caldeira J., Cunha C., Gonçalves R.M., Barbosa M.A.,
Inflammation in intervertebral disc degeneration and regeneration. Journal of the Royal Society Interface12(104):, 2015. [Journal: Review] [CI: 144] [IF: 3,8]
DOI: 10.1098/rsif.2014.1191 SCOPUS: 84923260818.

Caldeira J., Figueiredo J., Brás-Pereira C., Carneiro P., Moreira A.M., Pinto M.T., Relvas J.B., Carneiro F., Barbosa M., Casares F., Janody F., Seruca R.,
E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade. Human Molecular Genetics24(20):5891-5900, 2015. [Journal: Article] [CI: 13] [IF: 6]
DOI: 10.1093/hmg/ddv312 SCOPUS: 84943762566.

Caldeira J., Simões-Correia J., Paredes J., Sousa S., Corso G., Marrelli D., Roviello F., Pereira P.S., Weil D., Oliveira C., Casares F., Seruca R.,
CPEB1, a novel gene silenced in gastric cancer: A Drosophila approach. Gut61(8):1115-1123, 2012. [Journal: Article] [CI: 35] [IF: 10,7]
DOI: 10.1136/gutjnl-2011-300427 SCOPUS: 84863719147.

Paredes J., Figueiredo J., Albergaria A., Oliveira P., Carvalho J., Ribeiro A.S., Caldeira J., Costa A.M., Simões-Correia J., Oliveira M.J., Pinheiro H., Pinho S.S., Mateus R., Reis C.A., Leite M., Fernandes M.S., Schmitt F., Carneiro F., Figueiredo C., Oliveira C., Seruca R.,
Epithelial E- and P-cadherins: Role and clinical significance in cancer. Biochimica et Biophysica Acta - Reviews on Cancer1826(2):297-311, 2012. [Journal: Review] [CI: 137] [IF: 9]
DOI: 10.1016/j.bbcan.2012.05.002 SCOPUS: 84861800037.

Dichtel-Danjoy M.L., Caldeira J., Casares F.,
SoxF is part of a novel negative-feedback loop in the wingless pathway that controls proliferation in the Drosophila wing disc. Development136(5):761-769, 2009. [Journal: Article] [CI: 18] [IF: 7,2]
DOI: 10.1242/dev.032854 SCOPUS: 65549091070.

Pereira P.S., Teixeira A., Pinho S., Ferreira P., Fernandes J., Oliveira C., Seruca R., Suriano G., Casares F.,
E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia. Human Molecular Genetics15(10):1704-1712, 2006. [Journal: Article] [CI: 25] [IF: 8,1]
DOI: 10.1093/hmg/ddl093 SCOPUS: 33745184835.