Where Ideas Grow
Tânia Francisco
Junior Researcher
Tânia Francisco obtained her Cellular and Molecular Biology degree from the ?Universidade Nova de Lisboa? in 2006. After finishing her degree, she was a research fellow studying the genomic imprinting in human spermatogenesis at ?Faculdade de Medicina da Universidade do Porto?. In 2008, she joined the Organelle Biogenesis and Function Group at ?Instituto de Biologia Molecular e Celular ? Universidade do Porto?, where she developed her PhD thesis under the Biomedical Sciences PhD Program from ?Instituto de Ciências Biomédicas Abel Salazar ? Universidade do Porto?. Currently, she is a PostDoctoral researcher still focused on the molecular mechanisms of protein import into mammalian peroxisomes.

Selected Publications

Ferreira M.J., Rodrigues T.A., Pedrosa A.G., Gales L., Salvador A., Francisco T., Azevedo J.E.,
The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis. Redox Biology63:, 2023. [Journal: Article] [CI: 6] [IF: 11,4 (*)]
DOI: 10.1016/j.redox.2023.102764 SCOPUS: 85160316858.

Pedrosa A.G., Francisco T., Rodrigues T.A., Ferreira M.J., van der Heden van Noort G.J., Azevedo J.E.,
The Extraction Mechanism of Monoubiquitinated PEX5 from the Peroxisomal Membrane. Journal of Molecular Biology435(2):, 2023. [Journal: Article] [CI: 4] [IF: 5,6 (*)]
DOI: 10.1016/j.jmb.2022.167896 SCOPUS: 85145598058.

Ali M., Khan S.Y., Rodrigues T.A., Francisco T., Jiao X., Qi H., Kabir F., Irum B., Rauf B., Khan A.A., Mehmood A., Naeem M.A., Assir M.Z., Ali M.H., Shahzad M., Abu-Amero K.K., Akram S.J., Akram J., Riazuddin S., Riazuddin S., Robinson M.L., Baes M., Azevedo J.E., Hejtmancik J.F., Riazuddin S.A.,
A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes. Human Genetics140(4):649-666, 2021. [Journal: Article] [CI: 5] [IF: 5,9]
DOI: 10.1007/s00439-020-02238-z SCOPUS: 85098511203.

Barros-Barbosa A., Ferreira M.J., Rodrigues T.A., Pedrosa A.G., Grou C.P., Pinto M.P., Fransen M., Francisco T., Azevedo J.E.,
Membrane topologies of PEX13 and PEX14 provide new insights on the mechanism of protein import into peroxisomes. FEBS Journal286(1):205-222, 2019. [Journal: Article] [CI: 29] [IF: 4,4]
DOI: 10.1111/febs.14697 SCOPUS: 85057492540.

Pedrosa A.G., Francisco T., Bicho D., Dias A.F., Barros-Barbosa A., Hagmann V., Dodt G., Rodrigues T.A., Azevedo J.E.,
Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol. Journal of Biological Chemistry293(29):11553-11563, 2018. [Journal: Article] [CI: 31] [IF: 4,1]
DOI: 10.1074/jbc.RA118.003669 SCOPUS: 85050390152.

Francisco T., Rodrigues T.A., Dias A.F., Barros-Barbosa A., Bicho D., Azevedo J.E.,
Protein transport into peroxisomes: Knowns and unknowns. BioEssays39(10):, 2017. [Journal: Review] [CI: 54] [IF: 4,4]
DOI: 10.1002/bies.201700047 SCOPUS: 85029926379.

Rodrigues T.A., Francisco T., Dias A.F., Pedrosa A.G., Grou C.P., Azevedo J.E.,
A cell-free organelle-based in vitro system for studying the peroxisomal protein import machinery. Nature Protocols11(12):2454-2469, 2016. [Journal: Article] [CI: 10] [IF: 10]
DOI: 10.1038/nprot.2016.147 SCOPUS: 84996598602.

Freitas M.O., Francisco T., Rodrigues T.A., Lismont C., Domingues P., Pinto M.P., Grou C.P., Fransen M., Azevedo J.E.,
The peroxisomal protein import machinery displays a preference for monomeric substrates. Open Biology5(4):, 2015. [Journal: Article] [CI: 29] [IF: 4,8]
DOI: 10.1098/rsob.140236 SCOPUS: 84934927612.

Nordgren M., Francisco T., Lismont C., Hennebel L., Brees C., Wang B., van Veldhoven P.P., Azevedo J.E., Fransen M.,
Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts. Autophagy11(8):1326-1340, 2015. [Journal: Article] [CI: 70] [IF: 9,1]
DOI: 10.1080/15548627.2015.1061846 SCOPUS: 84943775216.

Francisco T., Rodrigues T.A., Freitas M.O., Grou C.P., Carvalho A.F., Sá-Miranda C., Pinto M.P., Azevedo J.E.,
A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway. Journal of Biological Chemistry288(40):29151-29159, 2013. [Journal: Article] [CI: 41] [IF: 4,6]
DOI: 10.1074/jbc.M113.487140 SCOPUS: 84885091904.