Tânia Francisco
Organelle Biogenesis & Function
Junior Researcher
Tânia Francisco obtained her Cellular and Molecular Biology degree from the Universidade Nova de Lisboa in 2006. After finishing her degree, she was a research fellow studying the genomic imprinting in human spermatogenesis at Faculdade de Medicina da Universidade do Porto. In 2008, she joined the Organelle Biogenesis and Function Group at Instituto de Biologia Molecular e Celular, Universidade do Porto, where she developed her PhD thesis under the Biomedical Sciences PhD Program from Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto. Currently, she is a senior researcher and is dedicated to the study of the molecular mechanisms of protein import into mammalian peroxisomes and to the mechanisms that regulate peroxisomal redox homeostasis.
Selected Publications
Francisco T., Pedrosa A.G., Rodrigues T.A., Abalkhail T., Li H., Ferreira M.J., van der Heden van Noort G.J., Fransen M., Hettema E.H., Azevedo J.E.
Noncanonical and reversible cysteine ubiquitination prevents the overubiquitination of PEX5 at the peroxisomal membrane. PLoS Biology22(3):, 2024. [Journal: Article] [IF: 7.8 (*)]
DOI: 10.1371/journal.pbio.3002567 SCOPUS: 85187686049
Ferreira M.J., Rodrigues T.A., Pedrosa A.G., Gales L., Salvador A., Francisco T., Azevedo J.E.
The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis. Redox Biology63:, 2023. [Journal: Article] [CI: 9] [IF: 10.7]
DOI: 10.1016/j.redox.2023.102764 SCOPUS: 85160316858
Ferreira M.J., Rodrigues T.A., Pedrosa A.G., Silva A.R., Vilarinho B.G., Francisco T., Azevedo J.E.
Glutathione and peroxisome redox homeostasis. Redox Biology67:, 2023. [Journal: Review] [CI: 21] [IF: 10.7]
DOI: 10.1016/j.redox.2023.102917 SCOPUS: 85173675911
Pedrosa A.G., Francisco T., Rodrigues T.A., Ferreira M.J., van der Heden van Noort G.J., Azevedo J.E.
The Extraction Mechanism of Monoubiquitinated PEX5 from the Peroxisomal Membrane. Journal of Molecular Biology435(2):, 2023. [Journal: Article] [CI: 8] [IF: 4.7]
DOI: 10.1016/j.jmb.2022.167896 SCOPUS: 85145598058
Ali M., Khan S.Y., Rodrigues T.A., Francisco T., Jiao X., Qi H., Kabir F., Irum B., Rauf B., Khan A.A., Mehmood A., Naeem M.A., Assir M.Z., Shahzad M., Abu-Amero K.K., Akram S.J., Akram J., Riazuddin S., Riazuddin S., Robinson M.L., Baes M., Azevedo J.E., Hejtmancik J.F., Riazuddin S.A.
A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes. Human Genetics140(4):649-666, 2021. [Journal: Article] [CI: 5] [IF: 5,9]
DOI: 10.1007/s00439-020-02238-z SCOPUS: 85098511203
Francisco T., Rodrigues T., Dias A., Barros-Barbosa A., Bicho D., Azevedo J.
Protein transport into peroxisomes: Knowns and unknowns. BioEssays39(10):, 2017. [Journal: Review] [CI: 59] [IF: 4,4]
DOI: 10.1002/bies.201700047 SCOPUS: 85029926379
Rodrigues T., Francisco T., Dias A., Pedrosa A., Grou C., Azevedo J.
A cell-free organelle-based in vitro system for studying the peroxisomal protein import machinery. Nature Protocols11(12):2454-2469, 2016. [Journal: Article] [CI: 12] [IF: 10]
DOI: 10.1038/nprot.2016.147 SCOPUS: 84996598602
Nordgren M., Francisco T., Lismont C., Hennebel L., Brees C., Wang B., van Veldhoven P.P., Azevedo J.E., Fransen M.
Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts. Autophagy11(8):1326-1340, 2015. [Journal: Article] [CI: 73] [IF: 9,1]
DOI: 10.1080/15548627.2015.1061846 SCOPUS: 84943775216
Francisco T., Rodrigues T.A., Freitas M.O., Grou C.P., Carvalho A.F., Sá-Miranda C., Pinto M.P., Azevedo J.E.
A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway. Journal of Biological Chemistry288(40):29151-29159, 2013. [Journal: Article] [CI: 45] [IF: 4,6]
DOI: 10.1074/jbc.M113.487140 SCOPUS: 84885091904
Noncanonical and reversible cysteine ubiquitination prevents the overubiquitination of PEX5 at the peroxisomal membrane. PLoS Biology22(3):, 2024. [Journal: Article] [IF: 7.8 (*)]
DOI: 10.1371/journal.pbio.3002567 SCOPUS: 85187686049
Ferreira M.J., Rodrigues T.A., Pedrosa A.G., Gales L., Salvador A., Francisco T., Azevedo J.E.
The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis. Redox Biology63:, 2023. [Journal: Article] [CI: 9] [IF: 10.7]
DOI: 10.1016/j.redox.2023.102764 SCOPUS: 85160316858
Ferreira M.J., Rodrigues T.A., Pedrosa A.G., Silva A.R., Vilarinho B.G., Francisco T., Azevedo J.E.
Glutathione and peroxisome redox homeostasis. Redox Biology67:, 2023. [Journal: Review] [CI: 21] [IF: 10.7]
DOI: 10.1016/j.redox.2023.102917 SCOPUS: 85173675911
Pedrosa A.G., Francisco T., Rodrigues T.A., Ferreira M.J., van der Heden van Noort G.J., Azevedo J.E.
The Extraction Mechanism of Monoubiquitinated PEX5 from the Peroxisomal Membrane. Journal of Molecular Biology435(2):, 2023. [Journal: Article] [CI: 8] [IF: 4.7]
DOI: 10.1016/j.jmb.2022.167896 SCOPUS: 85145598058
Ali M., Khan S.Y., Rodrigues T.A., Francisco T., Jiao X., Qi H., Kabir F., Irum B., Rauf B., Khan A.A., Mehmood A., Naeem M.A., Assir M.Z., Shahzad M., Abu-Amero K.K., Akram S.J., Akram J., Riazuddin S., Riazuddin S., Robinson M.L., Baes M., Azevedo J.E., Hejtmancik J.F., Riazuddin S.A.
A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes. Human Genetics140(4):649-666, 2021. [Journal: Article] [CI: 5] [IF: 5,9]
DOI: 10.1007/s00439-020-02238-z SCOPUS: 85098511203
Francisco T., Rodrigues T., Dias A., Barros-Barbosa A., Bicho D., Azevedo J.
Protein transport into peroxisomes: Knowns and unknowns. BioEssays39(10):, 2017. [Journal: Review] [CI: 59] [IF: 4,4]
DOI: 10.1002/bies.201700047 SCOPUS: 85029926379
Rodrigues T., Francisco T., Dias A., Pedrosa A., Grou C., Azevedo J.
A cell-free organelle-based in vitro system for studying the peroxisomal protein import machinery. Nature Protocols11(12):2454-2469, 2016. [Journal: Article] [CI: 12] [IF: 10]
DOI: 10.1038/nprot.2016.147 SCOPUS: 84996598602
Nordgren M., Francisco T., Lismont C., Hennebel L., Brees C., Wang B., van Veldhoven P.P., Azevedo J.E., Fransen M.
Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts. Autophagy11(8):1326-1340, 2015. [Journal: Article] [CI: 73] [IF: 9,1]
DOI: 10.1080/15548627.2015.1061846 SCOPUS: 84943775216
Francisco T., Rodrigues T.A., Freitas M.O., Grou C.P., Carvalho A.F., Sá-Miranda C., Pinto M.P., Azevedo J.E.
A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway. Journal of Biological Chemistry288(40):29151-29159, 2013. [Journal: Article] [CI: 45] [IF: 4,6]
DOI: 10.1074/jbc.M113.487140 SCOPUS: 84885091904