From early the evidence that the same piece of DNA gives origin to so many different cells, tissues and organisms puzzled me. Because of that I took a Biology degree at Faculty of Sciences at University of Porto. After that I was admitted to the GABBA PhD program, 9th edition, which gave me the opportunity to focus my studies in stem cell epigenetics in Neil Brockdorff lab first at the Biochemistry Department from the University of Oxford. I returned to Portugal in 2011 as an EMBO postdoctoral fellow and then as FCT postdoc at IBMC in Porto studying cell signaling and development of glial cells in a collaborative project between Cell growth and Differentiation and Glial Cell Biology labs. In 2019 I started a postdoc position at the Stem Cells & Neurogenesis merging my interests in transcriptional regulation and neural development. My current focus is on the characterization of the Gene Regulatory Network of the proneural transcription factor Ascl1 in the ventral telencephalon, where Ascl1 drives a GABAergic neurogenesis program characterized by high lineage expansion. In this context, I am particularly interested in how a cell autonomous cross-talk with the Notch pathway may impact the temporal regulation of Ascl1 target genes along the neuronal lineage, in response to distinct Notch signalling levels. For this, I am combining mouse genetics, genomics, and transcriptional assays.
Selected Publications
DOI: 10.1371/journal.pgen.1006647 SCOPUS: 85016620416.
Tavares L., Pereira E., Correia A., Santos M.A., Amaral N., Martins T., Relvas J.B., Pereira P.S.,
DOI: 10.1002/glia.22806 SCOPUS: 84928206519.
Tavares L., Dimitrova E., Oxley D., Webster J., Poot R., Demmers J., Bezstarosti K., Taylor S., Ura H., Koide H., Wutz A., Vidal M., Elderkin S., Brockdorff N.,
DOI: 10.1016/j.cell.2011.12.029 SCOPUS: 84857367297.
Landeira D., Sauer S., Poot R., Dvorkina M., Mazzarella L., Jørgensen H.F., Pereira C.F., Leleu M., Piccolo F.M., Spivakov M., Brookes E., Pombo A., Fisher C., Skarnes W.C., Snoek T., Bezstarosti K., Demmers J., Klose R.J., Casanova M., Tavares L., Brockdorff N., Merkenschlager M., Fisher A.G.,
DOI: 10.1038/ncb2065 SCOPUS: 77953120646.
López-Oarra A.M., Gusmão L., Tavares L., Baeza C., Amorim A., Mesa M.S., Prata M.J., Arroyo-Pardo E.,
DOI: 10.1111/j.1469-1809.2008.00478.x SCOPUS: 58149340827.
Trovoada M.J., Tavares L., Gusmão L., Alves C., Abade A., Amorim A., Prata M.J.,
DOI: 10.1111/j.1469-1809.2006.00309.x SCOPUS: 33845241931.
Lamghari M., Tavares L., Camboa N., Barbosa M.A.,
DOI: 10.1002/jcb.20853 SCOPUS: 33746452603.
Silva D.A., Carvalho E., Costa G., Tavares L., Amorim A., Gusmão L.,
DOI: 10.1002/ajhb.20567 SCOPUS: 33750874466.