Where Ideas Grow
Lígia Tavares
Visiting Researcher

From early the evidence that the same piece of DNA gives origin to so many different cells, tissues and organisms puzzled me. Because of that I took a Biology degree at Faculty of Sciences at University of Porto. After that I was admitted to the GABBA PhD program, 9th edition, which gave me the opportunity to focus my studies in stem cell epigenetics in Neil Brockdorff lab first at the Biochemistry Department from the University of Oxford. I returned to Portugal in 2011 as an EMBO postdoctoral fellow and then as FCT postdoc at IBMC in Porto studying cell signaling and development of glial cells in a collaborative project between Cell growth and Differentiation and Glial Cell Biology labs. In 2019 I started a postdoc position at the Stem Cells & Neurogenesis merging my interests in transcriptional regulation and neural development.  My current focus is on the characterization of the Gene Regulatory Network of the proneural transcription factor Ascl1 in the ventral telencephalon, where Ascl1 drives a GABAergic neurogenesis program characterized by high lineage expansion.  In this context, I am particularly interested in how a cell autonomous cross-talk with the Notch pathway may impact the temporal regulation of Ascl1 target genes along the neuronal lineage, in response to distinct Notch signalling levels.  For this, I am combining mouse genetics, genomics, and transcriptional assays.

Selected Publications

Tavares L., Correia A., Santos M.A., Relvas J.B., Pereira P.S.,
dMyc is required in retinal progenitors to prevent JNK-mediated retinal glial activation. PLoS Genetics13(3):, 2017. [Journal: Article] [CI: 7] [IF: 5,5]
DOI: 10.1371/journal.pgen.1006647 SCOPUS: 85016620416.

Tavares L., Pereira E., Correia A., Santos M.A., Amaral N., Martins T., Relvas J.B., Pereira P.S.,
Drosophila PS2 and PS3 integrins play distinct roles in retinal photoreceptors-glia interactions. GLIA63(7):1155-1165, 2015. [Journal: Article] [CI: 11] [IF: 6]
DOI: 10.1002/glia.22806 SCOPUS: 84928206519.

Tavares L., Dimitrova E., Oxley D., Webster J., Poot R., Demmers J., Bezstarosti K., Taylor S., Ura H., Koide H., Wutz A., Vidal M., Elderkin S., Brockdorff N.,
RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell148(4):664-678, 2012. [Journal: Article] [CI: 417] [IF: 32]
DOI: 10.1016/j.cell.2011.12.029 SCOPUS: 84857367297.

Landeira D., Sauer S., Poot R., Dvorkina M., Mazzarella L., Jørgensen H.F., Pereira C.F., Leleu M., Piccolo F.M., Spivakov M., Brookes E., Pombo A., Fisher C., Skarnes W.C., Snoek T., Bezstarosti K., Demmers J., Klose R.J., Casanova M., Tavares L., Brockdorff N., Merkenschlager M., Fisher A.G.,
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nature Cell Biology12(6):618-624, 2010. [Journal: Article] [CI: 234] [IF: 19,4]
DOI: 10.1038/ncb2065 SCOPUS: 77953120646.

López-Oarra A.M., Gusmão L., Tavares L., Baeza C., Amorim A., Mesa M.S., Prata M.J., Arroyo-Pardo E.,
In search of the pre- and post-neolithic genetic substrates in Iberia: Evidence from Y-chromosome in Pyrenean populations. Annals of Human Genetics73(1):42-53, 2009. [Journal: Article] [CI: 25] [IF: 2,1]
DOI: 10.1111/j.1469-1809.2008.00478.x SCOPUS: 58149340827.

Trovoada M.J., Tavares L., Gusmão L., Alves C., Abade A., Amorim A., Prata M.J.,
Dissecting the genetic history of São Tomé e Príncipe: A new window from Y-chromosome biallelic markers. Annals of Human Genetics71(1):77-85, 2007. [Journal: Article] [CI: 5] [IF: 2,3]
DOI: 10.1111/j.1469-1809.2006.00309.x SCOPUS: 33845241931.

Lamghari M., Tavares L., Camboa N., Barbosa M.A.,
Leptin effect on RANKL and OPG expression in MC3T3-E1 osteoblasts. Journal of Cellular Biochemistry98(5):1123-1129, 2006. [Journal: Article] [CI: 44] [IF: 3,4]
DOI: 10.1002/jcb.20853 SCOPUS: 33746452603.

Silva D.A., Carvalho E., Costa G., Tavares L., Amorim A., Gusmão L.,
Y-chromosome genetic variation in Rio de Janeiro population. American Journal of Human Biology18(6):829-837, 2006. [Journal: Article] [CI: 37] [IF: 1,7]
DOI: 10.1002/ajhb.20567 SCOPUS: 33750874466.