Where Ideas grow
Maria João Saraiva
Principal Researcher
Maria João Mascarenhas Saraiva received a BSc in biology from the University of Porto, Portugal, in 1976, and an MSc in Biochemistry from the University of London, in 1978. Between 1980 and 1984, she did a PhD in biochemistry at the University of Porto, and qualified as Professor of Biochemistry in 1991. She worked for different periods as a Visiting Scientist at the College of Physicians and Surgeons at Columbia University, New York. Maria J Saraiva was a Professor of Biochemistry at the Biomedical Institute; of Porto University and Director of the Molecular Neurobiology Group at the IBMC. Maria J Saraiva was awarded the Seiva Prize for Services to Science by the City of Porto, in 1996, and the Gulbenkian Prize in Science, in 2009. Recently, in 2019, she was awarded a national Medal from the Ministery of Science for Merrit in Science. She has published over 250 articles in peer reviewed journals, several reviews on the subject of Familial Amyloidotic Polyneuropathy and the Biology of Transthyretin and regularly delivers keynote lectures at international meetings on these subjects.h-index 58

Selected Publications

Maia L.F., Maceski A., Conceição I., Obici L., Magalhães R., Cortese A., Leppert D., Merlini G., Kuhle J., Saraiva M.J.,
Plasma neurofilament light chain: an early biomarker for hereditary ATTR amyloid polyneuropathy. Amyloid27(2):97-102, 2020. [Journal: Article] [CI: 4] [IF: 4,3 (*)]
DOI: 10.1080/13506129.2019.1708716 SCOPUS: 85077877879.

Gomes J.R., Cabrito I., Soares H.R., Costelha S., Teixeira A., Wittelsberger A., Stortelers C., Vanlandschoot P., Saraiva M.J.,
Delivery of an anti-transthyretin Nanobody to the brain through intranasal administration reveals transthyretin expression and secretion by motor neurons. Journal of Neurochemistry145(5):393-408, 2018. [Journal: Article] [CI: 7] [IF: 4,9]
DOI: 10.1111/jnc.14332 SCOPUS: 85046672101.

Gonçalves N.P., Moreira J., Martins D., Vieira P., Obici L., Merlini G., Saraiva M., Saraiva M.J.,
Differential expression of Cathepsin E in transthyretin amyloidosis: From neuropathology to the immune system. Journal of Neuroinflammation14(1):, 2017. [Journal: Article] [CI: 7] [IF: 5,2]
DOI: 10.1186/s12974-017-0891-9 SCOPUS: 85020206626.

Alemi M., Gaiteiro C., Ribeiro C.A., Santos L.M., Gomes J.R., Oliveira S.M., Couraud P.O., Weksler B., Romero I., Saraiva M.J., Cardoso I.,
Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?. Scientific Reports6:, 2016. [Journal: Article] [CI: 29] [IF: 4,3]
DOI: 10.1038/srep20164 SCOPUS: 84957818760.

Butler J.S., Chan A., Costelha S., Fishman S., Willoughby J.L.S., Borland T.D., Milstein S., Foster D.J., Gonçalves P., Chen Q., Qin J., Bettencourt B.R., Sah D.W., Alvarez R., Rajeev K.G., Manoharan M., Fitzgerald K., Meyers R.E., Nochur S.V., Saraiva M.J., Zimmermann T.S.,
Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis. Amyloid23(2):109-118, 2016. [Journal: Article] [CI: 59] [IF: 3,4]
DOI: 10.3109/13506129.2016.1160882 SCOPUS: 84962124696.

Gomes J.R., Nogueira R.S., Vieira M., Santos S.D., Ferraz-Nogueira J.P., Relvas J.B., Saraiva M.J.,
Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia. Cell Death and Differentiation23(11):1749-1764, 2016. [Journal: Article] [CI: 29] [IF: 8,3]
DOI: 10.1038/cdd.2016.64 SCOPUS: 84982105742.

Ferreira N., Gonçalves N.P., Saraiva M.J., Almeida M.R.,
Curcumin: A multi-Target disease-modifying agent for late-stage transthyretin amyloidosis. Scientific Reports6:, 2016. [Journal: Article] [CI: 30] [IF: 4,3]
DOI: 10.1038/srep26623 SCOPUS: 84969921377.

Gonçalves N.P., Vieira P., Saraiva M.J.,
Interleukin-1 signaling pathway as a therapeutic target in transthyretin amyloidosis. Amyloid21(3):175-184, 2014. [Journal: Article] [CI: 26] [IF: 2]
DOI: 10.3109/13506129.2014.927759 SCOPUS: 84906229959.

Vieira M., Saraiva M.J.,
Transthyretin: A multifaceted protein. Biomolecular Concepts5(1):45-54, 2014. [Journal: Review] [CI: 48]
DOI: 10.1515/bmc-2013-0038 SCOPUS: 84896800827.

Gonçalves N.P., Teixeira-Coelho M., Saraiva M.J.,
The inflammatory response to sciatic nerve injury in a familial amyloidotic polyneuropathy mouse model. Experimental Neurology257:76-87, 2014. [Journal: Article] [CI: 17] [IF: 4,7]
DOI: 10.1016/j.expneurol.2014.04.030 SCOPUS: 84900864199.