Rosário Almeida
Biomolecular Structure & Function
Senior Researcher
Rosário Almeida graduated in Biochemistry, by the University of Porto (UP), in 1986. Entered the academic career and, in parallel, developed a PhD in Biomedical Sciences that was concluded in 1995, at Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), UP. Currently, is Associate Professor of Biochemistry at ICBAS, and Principal Researcher at IBMC. Rosário Almeida main research interests aim to elucidate molecular mechanisms and pathophysiology of transthyretin amyloidosis and modulators of these processes. In this sense, investigates the effects of natural and synthetic compounds, in vitro and in vivo using animal models of familial amyloid polyneuropathy (FAP) aiming their potential therapeutic application in disease.
Participated in several projects, in particular, as PI in three projects, financed by FCT, and supervised several undergraduate students, 2 master students, 3 PhD students and 2 Post-Docs. Published about 60 articles in international peer reviewed journals and 1 book chapter (h-index of 28).
Selected Publications
Bezerra F., Niemietz C., Schmidt H.H.J., Zibert A., Guo S., Monia B.P., Gonçalves P., Saraiva M.J., Almeida M.R.
In vitro and in vivo effects of SerpinA1 on the modulation of transthyretin proteolysis. International Journal of Molecular Sciences22(17):, 2021. [Journal: Article] [CI: 11] [IF: 6,2]
DOI: 10.3390/ijms22179488 SCOPUS: 85114018847
Bezerra F., Saraiva M.J., Almeida M.R.
Modulation of the Mechanisms Driving Transthyretin Amyloidosis. Frontiers in Molecular Neuroscience13:, 2020. [Journal: Review] [CI: 40] [IF: 5,6]
DOI: 10.3389/fnmol.2020.592644 SCOPUS: 85098104145
Bezerra F., Simões C.J.V., Beirão J.M., Saraiva M.J., Brito R.M.M., Almeida M.R.
Targeting transthyretin amyloidosis in the eye with next-generation stabilizers: AT40 displays potent TTR stabilization in the human vitreous. Amyloid26(sup1):73-74, 2019. [Journal: Letter] [CI: 3] [IF: 4,3]
DOI: 10.1080/13506129.2019.1583193 SCOPUS: 85069628713
Ferreira N., Saraiva M.J., Almeida M.R.
Uncovering the neuroprotective mechanisms of curcumin on transthyretin amyloidosis. International Journal of Molecular Sciences20(6):, 2019. [Journal: Review] [CI: 39] [IF: 4,6]
DOI: 10.3390/ijms20061287 SCOPUS: 85062979338
Sant'Anna R., Almeida M.R., Varejao N., Gallego P., Esperante S., Ferreira P., Pereira-Henriques A., Palhano F.L., De Carvalho M., Foguel D., Reverter D., Saraiva M.J., Ventura S.
Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation. Scientific Reports7:, 2017. [Journal: Article] [CI: 28] [IF: 4,1]
DOI: 10.1038/srep44709 SCOPUS: 85016162023
Ferreira N., Gonçalves N.P., Saraiva M.J., Almeida M.R.
Curcumin: A multi-Target disease-modifying agent for late-stage transthyretin amyloidosis. Scientific Reports6:, 2016. [Journal: Article] [CI: 48] [IF: 4,3]
DOI: 10.1038/srep26623 SCOPUS: 84969921377
Ferreira N., Pereira-Henriques A., Almeida M.
Transthyretin chemical chaperoning by flavonoids: Structure-activity insights towards the design of potent amyloidosis inhibitors. Biochemistry and Biophysics Reports3:123-133, 2015. [Journal: Article] [CI: 26]
DOI: 10.1016/j.bbrep.2015.07.019 SCOPUS: 84939508272
Sant'Anna R., Gallego P., Robinson L.Z., Pereira-Henriques A., Ferreira N., Pinheiro F., Esperante S., Pallares I., Huertas O., Almeida M.R., Reixach N., Insa R., Velazquez-Campoy A., Reverter D., Reig N., Ventura S.
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity. Nature Communications7:, 2016. [Journal: Article] [CI: 162] [IF: 12,1]
DOI: 10.1038/ncomms10787 SCOPUS: 84959087061
Ferreira N., Pereira-Henriques A., Attar A., Klärner F.G., Schrader T., Bitan G., Gales L., Saraiva M.J., Almeida M.R.
Molecular Tweezers Targeting Transthyretin Amyloidosis. Neurotherapeutics11(2):450-461, 2014. [Journal: Article] [CI: 42] [IF: 5,1]
DOI: 10.1007/s13311-013-0256-8 SCOPUS: 84899492342
Ferreira N., Saraiva M.J., Almeida M.R.
Epigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis: "In vivo" evidence from FAP mice models. PLoS ONE7(1):, 2012. [Journal: Article] [CI: 101] [IF: 3,7]
DOI: 10.1371/journal.pone.0029933 SCOPUS: 84855650426
Ferreira N., Saraiva M., Almeida M.
Natural polyphenols as modulators of TTR amyloidogenesis: In vitro and in vivo evidences towards therapy. Amyloid19(SUPPL. 1):39-42, 2012. [Journal: Conference Paper] [CI: 26] [IF: 4,4]
DOI: 10.3109/13506129.2012.668502 SCOPUS: 84861433687
Saraiva M.J., Magalhaes J., Ferreira N., Almeida M.R.
Transthyretin deposition in familial amyloidotic polyneuropathy. Current Medicinal Chemistry19(15):2304-2311, 2012. [Journal: Article] [CI: 59] [IF: 4,1]
DOI: 10.2174/092986712800269236 SCOPUS: 84860663436
Ferreira N., Santos S., Domingues M., Saraiva M., Almeida M.
Dietary curcumin counteracts extracellular transthyretin deposition: Insights on the mechanism of amyloid inhibition. Biochimica et Biophysica Acta - Molecular Basis of Disease1832(1):39-45, 2013. [Journal: Article] [CI: 45] [IF: 5,1]
DOI: 10.1016/j.bbadis.2012.10.007 SCOPUS: 84868592337
Batista A.R., Gianni D., Ventosa M., Coelho A.V., Almeida M.R., Sena-Esteves M., Saraiva M.J.
Gene therapy approach to FAP: In vivo influence of T119M in TTR deposition in a transgenic V30M mouse model. Gene Therapy21(12):1041-1050, 2014. [Journal: Article] [CI: 10] [IF: 3,1]
DOI: 10.1038/gt.2014.86 SCOPUS: 84927178650
Batista A.R., Gianni D., Ventosa M., Coelho A.V., Almeida M.R., Sena-Esteves M., Saraiva M.J.
Gene therapy approach to FAP: In vivo influence of T119M in TTR deposition in a transgenic V30M mouse model (Gene Therapy advance online publication (2014) 10.1038/gt.2014.86)). Gene Therapy21(12):1065, 2014. [Journal: Erratum] [CI: 1] [IF: 3,1]
DOI: 10.1038/gt.2014.111 SCOPUS: 84927131539
Vilaró M., Nieto J., La Parra J.R., Almeida M.R., Ballesteros A., Planas A., Arsequell G., Valencia G.
Tuning transthyretin amyloidosis inhibition properties of iododiflunisal by combinatorial engineering of the nonsalicylic ring substitutions. ACS Combinatorial Science17(1):32-38, 2015. [Journal: Article] [CI: 18] [IF: 3,3]
DOI: 10.1021/co5001234 SCOPUS: 84921046996
Teixeira C., Almeida M., Saraiva M.
Impairment of autophagy by TTR V30M aggregates: In vivo reversal by TUDCA and curcumin. Clinical Science130(18):1665-1675, 2016. [Journal: Article] [CI: 11] [IF: 4,9]
DOI: 10.1042/CS20160075 SCOPUS: 85014362637
Simões C.J.V., Almeida Z.L., Costa D., Jesus C.S.H., Cardoso A.L., Almeida M.R., Saraiva M.J., Pinho e Melo T.M.V.D., Brito R.M.M.
A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition. European Journal of Medicinal Chemistry121:823-840, 2016. [Journal: Article] [CI: 19] [IF: 4,5]
DOI: 10.1016/j.ejmech.2016.02.074 SCOPUS: 84961839171
Simões C.J.V., Almeida Z.L., Cardoso A.L., Bezerra F., Almeida M.R., Beirão J., Pinho e Melo T.M.V.D., Saraiva M.J., Brito R.M.M.
Lead optimization of resilient next-generation transthyretin stabilizers for multiple target-product profiles: approaching the CNS. Amyloid26(sup1):77-78, 2019. [Journal: Letter] [CI: 2] [IF: 4,3]
DOI: 10.1080/13506129.2019.1583195 SCOPUS: 85069666459
Niemietz C., Bezerra F., Almeida M.R., Guo S., Monia B.P., Saraiva M.J., Schütz P., Schmidt H.H.J., Zibert A.
SERPINA1 modulates expression of amyloidogenic transthyretin. Experimental Cell Research395(2):, 2020. [Journal: Article] [CI: 8] [IF: 3,9]
DOI: 10.1016/j.yexcr.2020.112217 SCOPUS: 85089180606
Gião T., Teixeira T., Almeida M.R., Cardoso I.
Choroid Plexus in Alzheimer’s Disease—The Current State of Knowledge. Biomedicines10(2):, 2022. [Journal: Article] [CI: 56] [IF: 4,7]
DOI: 10.3390/biomedicines10020224 SCOPUS: 85124332509
Pinheiro F., Pallarès I., Peccati F., Sánchez-Morales A., Varejão N., Bezerra F., Ortega-Alarcon D., Gonzalez D., Osorio M., Navarro S., Velázquez-Campoy A., Almeida M.R., Reverter D., Busqué F., Alibés R., Sodupe M., Ventura S.
Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation. Journal of Medicinal Chemistry65(21):14673-14691, 2022. [Journal: Article] [CI: 17] [IF: 7,3]
DOI: 10.1021/acs.jmedchem.2c01195 SCOPUS: 85141607753
Sant’Anna R., Gallego P., Robinson L.Z., Pereira-Henriques A., Ferreira N., Pinheiro F., Esperante S., Pallares I., Huertas O., Almeida M.R., Reixach N., Insa R., Velazquez-Campoy A., Reverter D., Reig N., Ventura S.
Author Correction: Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity (Nature Communications, (2016), 7, 1, (10787), 10.1038/ncomms10787). Nature Communications14(1):, 2023. [Journal: Erratum] [IF: 16,6 (*)]
DOI: 10.1038/s41467-023-36239-z SCOPUS: 85147332335
Pinheiro F., Varejão N., Sánchez-Morales A., Bezerra F., Navarro S., Velázquez-Campoy A., Busqué F., Almeida M.R., Alibés R., Reverter D., Pallarès I., Ventura S.
PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. European Journal of Medicinal Chemistry261:, 2023. [Journal: Article] [CI: 7] [IF: 6]
DOI: 10.1016/j.ejmech.2023.115837 SCOPUS: 85173219233
Costa-Rodrigues D., Leite J.P., Saraiva M.J., Almeida M.R., Gales L.
Transthyretin monomers: a new plasma biomarker for pre-symptomatic transthyretin-related amyloidosis. Amyloid31(3):202-208, 2024. [Journal: Article] [CI: 5] [IF: 7.4]
DOI: 10.1080/13506129.2024.2368860 SCOPUS: 85197576597
Almeida M., Saraiva M.
Clearance of extracellular misfolded proteins in systemic amyloidosis: Experience with transthyretin. FEBS Letters586(18):2891-2896, 2012. [Journal: Conference Paper] [CI: 28] [IF: 3,6]
DOI: 10.1016/j.febslet.2012.07.029 SCOPUS: 84864931018
Ferreira N., Saraiva M.J., Almeida M.R.
Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation. FEBS Letters585(15):2424-2430, 2011. [Journal: Article] [CI: 156] [IF: 3,5]
DOI: 10.1016/j.febslet.2011.06.030 SCOPUS: 79960910835
Martinho A., Gonçalves I., Cardoso I., Almeida M., Quintela T., Saraiva M., Santos C.
Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin. FEBS Journal277(16):3427-3436, 2010. [Journal: Article] [CI: 27] [IF: 3,1]
DOI: 10.1111/j.1742-4658.2010.07749.x SCOPUS: 77955239777
Pessoa J., Sárkány Z., Ferreira-da-Silva F., Martins S., Almeida M.R., Li J., Damas A.M.
Functional characterization of Arabidopsis thaliana transthyretin-like protein. BMC Plant Biology10:, 2010. [Journal: Article] [CI: 35] [IF: 4,1]
DOI: 10.1186/1471-2229-10-30 SCOPUS: 77949472438
Liz M.A., Fleming C.E., Nunes A.F., Almeida M.R., Mar F.M., Choe Y., Craik C.S., Powers J.C., Bogyo M., Sousa M.M.
Substrate specificity of transthyretin: Identification of natural substrates in the nervous system. Biochemical Journal419(2):467-474, 2009. [Journal: Article] [CI: 47] [IF: 5,2]
DOI: 10.1042/BJ20082090 SCOPUS: 64249132020
Ferreira N., Cardoso I., Domingues M., Vitorino R., Bastos M., Bai G., Saraiva M., Almeida M.
Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity. FEBS Letters583(22):3569-3576, 2009. [Journal: Article] [CI: 129] [IF: 3,5]
DOI: 10.1016/j.febslet.2009.10.062 SCOPUS: 71749085436
Mairal T., Nieto J., Pinto M., Almeida M.R., Gales L., Ballesteros A., Barluenga J., Pérez J.J., Vázquez J.T., Centeno N.B., Saraiva M.J., Damas A.M., Planas A., Arsequell G., Valencia G.
Iodine atoms: A new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. PLoS ONE4(1):, 2009. [Journal: Article] [CI: 54] [IF: 4,4]
DOI: 10.1371/journal.pone.0004124 SCOPUS: 59249100931
González A., Quirante J., Nieto J., Almeida M.R., Saraiva M.J., Planas A., Arsequell G., Valencia G.
Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors. Bioorganic and Medicinal Chemistry Letters19(17):5270-5273, 2009. [Journal: Article] [CI: 48] [IF: 2,7]
DOI: 10.1016/j.bmcl.2009.03.004 SCOPUS: 68549085257
Gonçalves I., Quintela T., Baltazar G., Almeida M., Saraiva M., Santos C.
Transthyretin interacts with metallothionein 2. Biochemistry47(8):2244-2251, 2008. [Journal: Article] [CI: 35] [IF: 3,4]
DOI: 10.1021/bi7016377 SCOPUS: 39749120520
Gales L., Almeida M.R., Arsequell G., Valencia G., Saraiva M.J., Damas A.M.
Iodination of salicylic acid improves its binding to transthyretin. Biochimica et Biophysica Acta - Proteins and Proteomics1784(3):512-517, 2008. [Journal: Article] [CI: 25] [IF: 2,2]
DOI: 10.1016/j.bbapap.2007.11.014 SCOPUS: 43049162388
Macedo B., Batista A., Ferreira N., Almeida M., Saraiva M.
Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy. Biochimica et Biophysica Acta - Molecular Basis of Disease1782(9):517-522, 2008. [Journal: Article] [CI: 68] [IF: 4,6]
DOI: 10.1016/j.bbadis.2008.05.005 SCOPUS: 49349097870
Cardoso I., Almeida M., Ferreira N., Arsequell G., Valencia G., Saraiva M.
Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: Relevance in drug design. Biochemical Journal408(1):131-138, 2007. [Journal: Article] [CI: 30] [IF: 4]
DOI: 10.1042/BJ20070689 SCOPUS: 36348960658
Magalhães V., Veiga-Malta I., Almeida M.R., Baptista M., Ribeiro A., Trieu-Cuot P., Ferreira P.
Interaction with human plasminogen system turns on proteolytic activity in Streptococcus agalactiae and enhances its virulence in a mouse model. Microbes and Infection9(11):1276-1284, 2007. [Journal: Article] [CI: 37] [IF: 2,5]
DOI: 10.1016/j.micinf.2007.06.001 SCOPUS: 35148826082
Damas A., Almeida M., Gales L., Cardoso I., Saraiva M.
Pharmacologic approaches in the treatment of familial amyloidotic polyneuropathy. Sinapse6(1 SUPPL. 1):168-173, 2006. [Journal: Article] [CI: 1]
SCOPUS: 33745382011
Maia F., Almeida M.D.R., Gales L., Kijjoa A., Pinto M.M.M., Saraiva M.J., Damas A.M.
The binding of xanthone derivatives to transthyretin. Biochemical Pharmacology70(12):1861-1869, 2005. [Journal: Article] [CI: 35] [IF: 3,6]
DOI: 10.1016/j.bcp.2005.09.012 SCOPUS: 27744528447
Almeida M., Gales L., Damas A., Cardoso I., Saraiva M.
Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses. Current Drug Targets: CNS and Neurological Disorders4(5):587-596, 2005. [Journal: Review] [CI: 60]
DOI: 10.2174/156800705774322076 SCOPUS: 26844484754
Almeida M., Macedo B., Cardoso I., Valencia G., Arsequell G., Planas A., Saraiva M.
Effects of a new diflunisal derivative on transthyretin binding and stabilization in serum from FAP patients. Amyloid and Amyloidosis:497-499, 2004. [Book: Book Chapter]
SCOPUS: 85057673222
Almeida M., Macedo B., Cardoso I., Alves I., Valencia G., Arsequell G., Planas A., Saraiva M.
Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative. Biochemical Journal381(2):351-356, 2004. [Journal: Article] [CI: 88] [IF: 4,3]
DOI: 10.1042/BJ20040011 SCOPUS: 3242807241
Almeida M., Alves I., Terazaki H., Ando Y., Saraiva M.
Comparative studies of two transthyretin variants with protective effects on familial amyloidotic polyneuropathy: TTR R104H and TTR T119M. Biochemical and Biophysical Research Communications270(3):1024-1028, 2000. [Journal: Article] [CI: 61] [IF: 3,1]
DOI: 10.1006/bbrc.2000.2554 SCOPUS: 0034696835
Ando Y., Almeida M.D.R., Ohlsson P.I., Ando E., Negi A., Suhr O., Terazaki H., Obayashi K., Ando M., Saraiva M.J.M.
Unusual self-association properties of transthyretin Y114C related to familial amyloidotic polyneuropathy: Effects on detection and quantification. Biochemical and Biophysical Research Communications261(2):264-269, 1999. [Journal: Article] [CI: 12] [IF: 3,2]
DOI: 10.1006/bbrc.1999.1048 SCOPUS: 0344069494
Almeida M.R., Damas A.M., Lans M.C., Brouwer A., Saraiva M.J.
Thyroxine binding to transthyretin Met 119: Comparative studies of different heterozygotic carriers and structural analysis. Endocrine6(3):309-315, 1997. [Journal: Article] [CI: 91]
DOI: 10.1007/BF02820508 SCOPUS: 0030885583
Alves I., Altland K., Almeida M., Winter P., Saraiva M.
Screening and biochemical characterization of transthyretin variants in the Portuguese population. Human Mutation9(3):226-233, 1997. [Journal: Article] [CI: 51] [IF: 2,3]
DOI: 10.1002/(SICI)1098-1004(1997)9:3<226::AID-HUMU3>3.0.CO;2-5 SCOPUS: 0030992434
Almeida M., Saraiva M.
Thyroxine binding to transthyretin (TTR) variants - Two variants (TTR Pro 55 and TTR met 111) with a particularly low binding affinity. European Journal of Endocrinology135(2):226-230, 1996. [Journal: Article] [CI: 19]
DOI: 10.1530/eje.0.1350226 SCOPUS: 0029831901
Saraiva M.J.M., Almeida M.R., Alves I.L., Bonifacio M.J., Damas A.M., Palha J.A., Goldsteins G., Lundgren E.
Modulating conformational factors in transthyretin amyloid. CIBA Foundation Symposia(199):47-57, 1996. [Journal: Article] [CI: 9]
SCOPUS: 0030345867
de Fatima Torres M., do Rosário Almeida M., Saraiva M.J.
TTR exon scanning in peripheral neuropathies. Neuromuscular Disorders5(3):187-191, 1995. [Journal: Article] [CI: 19]
DOI: 10.1016/0960-8966(94)00054-D SCOPUS: 0029020077
Saraiva M.J.M., Costa P.P., Almeida M.d.R., Banzhoff A., Altland K., Ferlini A., Rubboli G., Plasmati R., Tassinari C.A., Romeo G., Salvi F.
Familial amyloidotic polyneuropathy: transthyretin (prealbumin) variants in kindreds of Italian origin. Human Genetics80(4):341-343, 1988. [Journal: Article] [CI: 10]
DOI: 10.1007/BF00273648 SCOPUS: 0024232963
Almeida M., Alves I., Sakaki Y., Costa P., Saraiva M.
Prenatal diagnosis of familial amyloidotic polyneuropathy: evidence for an early expression of the associated transthyretin methionine 30. Human Genetics85(6):623-626, 1990. [Journal: Article] [CI: 32]
DOI: 10.1007/BF00193586 SCOPUS: 0025076810
Almeida M., Hesse A., Steinmetz A., Maisch B., Altland K., Linker R., Gawinowicz M., Saraiva M.
Transthyretin Leu 68 in a form of cardiac amyloidosis. Basic Research in Cardiology86(6):567-571, 1991. [Journal: Article] [CI: 40]
DOI: 10.1007/BF02190707 SCOPUS: 0026331577
Saraiva M.J.M., Almeida M.D.R., Alves I.L., Moreira P., Gawinowicz M.A., Costa P.P., Rauh S., Banhzoff A., Altland K.
Molecular analyses of an acidic transthyretin Asn 90 variant. American Journal of Human Genetics48(5):1004-1008, 1991. [Journal: Article] [CI: 31]
SCOPUS: 0025853733
Alves I.L., Almeida M.R., Skare J., Skinner M., Kurose K., Sakaki Y., Costa P.P., Saraiva M.J.M.
Amyloidogenic and non‐amyloidogenic transthyretin Asn 90 variants. Clinical Genetics42(1):27-30, 1992. [Journal: Article] [CI: 11]
DOI: 10.1111/j.1399-0004.1992.tb03131.x SCOPUS: 0026691223
Saraiva M.J.M., Almeida M.D.R., Sherman W., Gawinowicz M., Costa P., Costa P.P., Goodman D.W.S.
A new transthyretin mutation associated with amyloid cardiomyopathy. American Journal of Human Genetics50(5):1027-1030, 1992. [Journal: Article] [CI: 33]
SCOPUS: 0026724677
Almeida M.d.R., Ferlini A., Forabosco A., Gawinowicz M., Costa P.P., Salvi F., Plasmati R., Tassinari C.A., Altland K., Saraiva M.J.
Two transthyretin variants (TTR Ala‐49 and TTR Gln‐89) in two sicilian kindreds with hereditary amyloidosis. Human Mutation1(3):211-215, 1992. [Journal: Article] [CI: 43]
DOI: 10.1002/humu.1380010306 SCOPUS: 0027023491
Almeida M., Lopez‐Andreu F., Munar‐Qués M., Costa P., Saraiva M.
Transthyretin ALA 71: A new transthyretin variant in a Spanish family with familial amyloidotic polyneuropathy. Human Mutation2(5):420-421, 1993. [Journal: Article] [CI: 16]
DOI: 10.1002/humu.1380020516 SCOPUS: 0027495964
López Andreu F.R., Munar-Qués M., Parrilla P., Escribano Soriano J.B., Costa P.P., Costa P.M., Almeida M.R., Pons J.A., Robles R., Sánchez-Bueno F.
Liver transplantation for the treatment of type I familial amyloidotic polyneuropathy. Medicina clinica101(15):581-583, 1993. [Journal: Article] [CI: 8]
SCOPUS: 0039317638
Hesse A., Altland K., Linke R.P., Almeida M.R., Saraiva M.J.M., Steinmetz A., Maisch B.
Cardiac amyloidosis: A review and report of a new transthyretin (prealbumin) variant. British Heart Journal70(2):111-115, 1993. [Journal: Article] [CI: 47]
DOI: 10.1136/hrt.70.2.111 SCOPUS: 0027170502
Alves I.L., Divino C.M., Schussler G.C., Altland K., Almeida M.R., Palha J.A., Coelho T., Costa P.P., Saraiva M.J.M.
Thyroxine binding in a TTR Met 119 kindred. Journal of Clinical Endocrinology and Metabolism77(2):484-488, 1993. [Journal: Article] [CI: 37]
SCOPUS: 0027240115
Almeida M., Saraiva M.
TTR leu 64 in an FAP kindred identified by PCR-RFLP analysis. Amyloid1(3):184-185, 1994. [Journal: Article] [CI: 1]
DOI: 10.3109/13506129409148450 SCOPUS: 0028082978
Almeida M.R., Aoyama-Oishi N., Sakaki Y., Holmgren G., Ulf D., Ferlini A., Salvi F., Munar-Qués M., Benson M.D., Skinner M., Costa P.P., Saraiva M.J.
Haplotype analysis of common transthyretin mutations. Human Genetics96(3):350-354, 1995. [Journal: Article] [CI: 23]
DOI: 10.1007/BF00210422 SCOPUS: 0029116835
In vitro and in vivo effects of SerpinA1 on the modulation of transthyretin proteolysis. International Journal of Molecular Sciences22(17):, 2021. [Journal: Article] [CI: 11] [IF: 6,2]
DOI: 10.3390/ijms22179488 SCOPUS: 85114018847
Bezerra F., Saraiva M.J., Almeida M.R.
Modulation of the Mechanisms Driving Transthyretin Amyloidosis. Frontiers in Molecular Neuroscience13:, 2020. [Journal: Review] [CI: 40] [IF: 5,6]
DOI: 10.3389/fnmol.2020.592644 SCOPUS: 85098104145
Bezerra F., Simões C.J.V., Beirão J.M., Saraiva M.J., Brito R.M.M., Almeida M.R.
Targeting transthyretin amyloidosis in the eye with next-generation stabilizers: AT40 displays potent TTR stabilization in the human vitreous. Amyloid26(sup1):73-74, 2019. [Journal: Letter] [CI: 3] [IF: 4,3]
DOI: 10.1080/13506129.2019.1583193 SCOPUS: 85069628713
Ferreira N., Saraiva M.J., Almeida M.R.
Uncovering the neuroprotective mechanisms of curcumin on transthyretin amyloidosis. International Journal of Molecular Sciences20(6):, 2019. [Journal: Review] [CI: 39] [IF: 4,6]
DOI: 10.3390/ijms20061287 SCOPUS: 85062979338
Sant'Anna R., Almeida M.R., Varejao N., Gallego P., Esperante S., Ferreira P., Pereira-Henriques A., Palhano F.L., De Carvalho M., Foguel D., Reverter D., Saraiva M.J., Ventura S.
Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation. Scientific Reports7:, 2017. [Journal: Article] [CI: 28] [IF: 4,1]
DOI: 10.1038/srep44709 SCOPUS: 85016162023
Ferreira N., Gonçalves N.P., Saraiva M.J., Almeida M.R.
Curcumin: A multi-Target disease-modifying agent for late-stage transthyretin amyloidosis. Scientific Reports6:, 2016. [Journal: Article] [CI: 48] [IF: 4,3]
DOI: 10.1038/srep26623 SCOPUS: 84969921377
Ferreira N., Pereira-Henriques A., Almeida M.
Transthyretin chemical chaperoning by flavonoids: Structure-activity insights towards the design of potent amyloidosis inhibitors. Biochemistry and Biophysics Reports3:123-133, 2015. [Journal: Article] [CI: 26]
DOI: 10.1016/j.bbrep.2015.07.019 SCOPUS: 84939508272
Sant'Anna R., Gallego P., Robinson L.Z., Pereira-Henriques A., Ferreira N., Pinheiro F., Esperante S., Pallares I., Huertas O., Almeida M.R., Reixach N., Insa R., Velazquez-Campoy A., Reverter D., Reig N., Ventura S.
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity. Nature Communications7:, 2016. [Journal: Article] [CI: 162] [IF: 12,1]
DOI: 10.1038/ncomms10787 SCOPUS: 84959087061
Ferreira N., Pereira-Henriques A., Attar A., Klärner F.G., Schrader T., Bitan G., Gales L., Saraiva M.J., Almeida M.R.
Molecular Tweezers Targeting Transthyretin Amyloidosis. Neurotherapeutics11(2):450-461, 2014. [Journal: Article] [CI: 42] [IF: 5,1]
DOI: 10.1007/s13311-013-0256-8 SCOPUS: 84899492342
Ferreira N., Saraiva M.J., Almeida M.R.
Epigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis: "In vivo" evidence from FAP mice models. PLoS ONE7(1):, 2012. [Journal: Article] [CI: 101] [IF: 3,7]
DOI: 10.1371/journal.pone.0029933 SCOPUS: 84855650426
Ferreira N., Saraiva M., Almeida M.
Natural polyphenols as modulators of TTR amyloidogenesis: In vitro and in vivo evidences towards therapy. Amyloid19(SUPPL. 1):39-42, 2012. [Journal: Conference Paper] [CI: 26] [IF: 4,4]
DOI: 10.3109/13506129.2012.668502 SCOPUS: 84861433687
Saraiva M.J., Magalhaes J., Ferreira N., Almeida M.R.
Transthyretin deposition in familial amyloidotic polyneuropathy. Current Medicinal Chemistry19(15):2304-2311, 2012. [Journal: Article] [CI: 59] [IF: 4,1]
DOI: 10.2174/092986712800269236 SCOPUS: 84860663436
Ferreira N., Santos S., Domingues M., Saraiva M., Almeida M.
Dietary curcumin counteracts extracellular transthyretin deposition: Insights on the mechanism of amyloid inhibition. Biochimica et Biophysica Acta - Molecular Basis of Disease1832(1):39-45, 2013. [Journal: Article] [CI: 45] [IF: 5,1]
DOI: 10.1016/j.bbadis.2012.10.007 SCOPUS: 84868592337
Batista A.R., Gianni D., Ventosa M., Coelho A.V., Almeida M.R., Sena-Esteves M., Saraiva M.J.
Gene therapy approach to FAP: In vivo influence of T119M in TTR deposition in a transgenic V30M mouse model. Gene Therapy21(12):1041-1050, 2014. [Journal: Article] [CI: 10] [IF: 3,1]
DOI: 10.1038/gt.2014.86 SCOPUS: 84927178650
Batista A.R., Gianni D., Ventosa M., Coelho A.V., Almeida M.R., Sena-Esteves M., Saraiva M.J.
Gene therapy approach to FAP: In vivo influence of T119M in TTR deposition in a transgenic V30M mouse model (Gene Therapy advance online publication (2014) 10.1038/gt.2014.86)). Gene Therapy21(12):1065, 2014. [Journal: Erratum] [CI: 1] [IF: 3,1]
DOI: 10.1038/gt.2014.111 SCOPUS: 84927131539
Vilaró M., Nieto J., La Parra J.R., Almeida M.R., Ballesteros A., Planas A., Arsequell G., Valencia G.
Tuning transthyretin amyloidosis inhibition properties of iododiflunisal by combinatorial engineering of the nonsalicylic ring substitutions. ACS Combinatorial Science17(1):32-38, 2015. [Journal: Article] [CI: 18] [IF: 3,3]
DOI: 10.1021/co5001234 SCOPUS: 84921046996
Teixeira C., Almeida M., Saraiva M.
Impairment of autophagy by TTR V30M aggregates: In vivo reversal by TUDCA and curcumin. Clinical Science130(18):1665-1675, 2016. [Journal: Article] [CI: 11] [IF: 4,9]
DOI: 10.1042/CS20160075 SCOPUS: 85014362637
Simões C.J.V., Almeida Z.L., Costa D., Jesus C.S.H., Cardoso A.L., Almeida M.R., Saraiva M.J., Pinho e Melo T.M.V.D., Brito R.M.M.
A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition. European Journal of Medicinal Chemistry121:823-840, 2016. [Journal: Article] [CI: 19] [IF: 4,5]
DOI: 10.1016/j.ejmech.2016.02.074 SCOPUS: 84961839171
Simões C.J.V., Almeida Z.L., Cardoso A.L., Bezerra F., Almeida M.R., Beirão J., Pinho e Melo T.M.V.D., Saraiva M.J., Brito R.M.M.
Lead optimization of resilient next-generation transthyretin stabilizers for multiple target-product profiles: approaching the CNS. Amyloid26(sup1):77-78, 2019. [Journal: Letter] [CI: 2] [IF: 4,3]
DOI: 10.1080/13506129.2019.1583195 SCOPUS: 85069666459
Niemietz C., Bezerra F., Almeida M.R., Guo S., Monia B.P., Saraiva M.J., Schütz P., Schmidt H.H.J., Zibert A.
SERPINA1 modulates expression of amyloidogenic transthyretin. Experimental Cell Research395(2):, 2020. [Journal: Article] [CI: 8] [IF: 3,9]
DOI: 10.1016/j.yexcr.2020.112217 SCOPUS: 85089180606
Gião T., Teixeira T., Almeida M.R., Cardoso I.
Choroid Plexus in Alzheimer’s Disease—The Current State of Knowledge. Biomedicines10(2):, 2022. [Journal: Article] [CI: 56] [IF: 4,7]
DOI: 10.3390/biomedicines10020224 SCOPUS: 85124332509
Pinheiro F., Pallarès I., Peccati F., Sánchez-Morales A., Varejão N., Bezerra F., Ortega-Alarcon D., Gonzalez D., Osorio M., Navarro S., Velázquez-Campoy A., Almeida M.R., Reverter D., Busqué F., Alibés R., Sodupe M., Ventura S.
Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation. Journal of Medicinal Chemistry65(21):14673-14691, 2022. [Journal: Article] [CI: 17] [IF: 7,3]
DOI: 10.1021/acs.jmedchem.2c01195 SCOPUS: 85141607753
Sant’Anna R., Gallego P., Robinson L.Z., Pereira-Henriques A., Ferreira N., Pinheiro F., Esperante S., Pallares I., Huertas O., Almeida M.R., Reixach N., Insa R., Velazquez-Campoy A., Reverter D., Reig N., Ventura S.
Author Correction: Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity (Nature Communications, (2016), 7, 1, (10787), 10.1038/ncomms10787). Nature Communications14(1):, 2023. [Journal: Erratum] [IF: 16,6 (*)]
DOI: 10.1038/s41467-023-36239-z SCOPUS: 85147332335
Pinheiro F., Varejão N., Sánchez-Morales A., Bezerra F., Navarro S., Velázquez-Campoy A., Busqué F., Almeida M.R., Alibés R., Reverter D., Pallarès I., Ventura S.
PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. European Journal of Medicinal Chemistry261:, 2023. [Journal: Article] [CI: 7] [IF: 6]
DOI: 10.1016/j.ejmech.2023.115837 SCOPUS: 85173219233
Costa-Rodrigues D., Leite J.P., Saraiva M.J., Almeida M.R., Gales L.
Transthyretin monomers: a new plasma biomarker for pre-symptomatic transthyretin-related amyloidosis. Amyloid31(3):202-208, 2024. [Journal: Article] [CI: 5] [IF: 7.4]
DOI: 10.1080/13506129.2024.2368860 SCOPUS: 85197576597
Almeida M., Saraiva M.
Clearance of extracellular misfolded proteins in systemic amyloidosis: Experience with transthyretin. FEBS Letters586(18):2891-2896, 2012. [Journal: Conference Paper] [CI: 28] [IF: 3,6]
DOI: 10.1016/j.febslet.2012.07.029 SCOPUS: 84864931018
Ferreira N., Saraiva M.J., Almeida M.R.
Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation. FEBS Letters585(15):2424-2430, 2011. [Journal: Article] [CI: 156] [IF: 3,5]
DOI: 10.1016/j.febslet.2011.06.030 SCOPUS: 79960910835
Martinho A., Gonçalves I., Cardoso I., Almeida M., Quintela T., Saraiva M., Santos C.
Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin. FEBS Journal277(16):3427-3436, 2010. [Journal: Article] [CI: 27] [IF: 3,1]
DOI: 10.1111/j.1742-4658.2010.07749.x SCOPUS: 77955239777
Pessoa J., Sárkány Z., Ferreira-da-Silva F., Martins S., Almeida M.R., Li J., Damas A.M.
Functional characterization of Arabidopsis thaliana transthyretin-like protein. BMC Plant Biology10:, 2010. [Journal: Article] [CI: 35] [IF: 4,1]
DOI: 10.1186/1471-2229-10-30 SCOPUS: 77949472438
Liz M.A., Fleming C.E., Nunes A.F., Almeida M.R., Mar F.M., Choe Y., Craik C.S., Powers J.C., Bogyo M., Sousa M.M.
Substrate specificity of transthyretin: Identification of natural substrates in the nervous system. Biochemical Journal419(2):467-474, 2009. [Journal: Article] [CI: 47] [IF: 5,2]
DOI: 10.1042/BJ20082090 SCOPUS: 64249132020
Ferreira N., Cardoso I., Domingues M., Vitorino R., Bastos M., Bai G., Saraiva M., Almeida M.
Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity. FEBS Letters583(22):3569-3576, 2009. [Journal: Article] [CI: 129] [IF: 3,5]
DOI: 10.1016/j.febslet.2009.10.062 SCOPUS: 71749085436
Mairal T., Nieto J., Pinto M., Almeida M.R., Gales L., Ballesteros A., Barluenga J., Pérez J.J., Vázquez J.T., Centeno N.B., Saraiva M.J., Damas A.M., Planas A., Arsequell G., Valencia G.
Iodine atoms: A new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. PLoS ONE4(1):, 2009. [Journal: Article] [CI: 54] [IF: 4,4]
DOI: 10.1371/journal.pone.0004124 SCOPUS: 59249100931
González A., Quirante J., Nieto J., Almeida M.R., Saraiva M.J., Planas A., Arsequell G., Valencia G.
Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors. Bioorganic and Medicinal Chemistry Letters19(17):5270-5273, 2009. [Journal: Article] [CI: 48] [IF: 2,7]
DOI: 10.1016/j.bmcl.2009.03.004 SCOPUS: 68549085257
Gonçalves I., Quintela T., Baltazar G., Almeida M., Saraiva M., Santos C.
Transthyretin interacts with metallothionein 2. Biochemistry47(8):2244-2251, 2008. [Journal: Article] [CI: 35] [IF: 3,4]
DOI: 10.1021/bi7016377 SCOPUS: 39749120520
Gales L., Almeida M.R., Arsequell G., Valencia G., Saraiva M.J., Damas A.M.
Iodination of salicylic acid improves its binding to transthyretin. Biochimica et Biophysica Acta - Proteins and Proteomics1784(3):512-517, 2008. [Journal: Article] [CI: 25] [IF: 2,2]
DOI: 10.1016/j.bbapap.2007.11.014 SCOPUS: 43049162388
Macedo B., Batista A., Ferreira N., Almeida M., Saraiva M.
Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy. Biochimica et Biophysica Acta - Molecular Basis of Disease1782(9):517-522, 2008. [Journal: Article] [CI: 68] [IF: 4,6]
DOI: 10.1016/j.bbadis.2008.05.005 SCOPUS: 49349097870
Cardoso I., Almeida M., Ferreira N., Arsequell G., Valencia G., Saraiva M.
Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: Relevance in drug design. Biochemical Journal408(1):131-138, 2007. [Journal: Article] [CI: 30] [IF: 4]
DOI: 10.1042/BJ20070689 SCOPUS: 36348960658
Magalhães V., Veiga-Malta I., Almeida M.R., Baptista M., Ribeiro A., Trieu-Cuot P., Ferreira P.
Interaction with human plasminogen system turns on proteolytic activity in Streptococcus agalactiae and enhances its virulence in a mouse model. Microbes and Infection9(11):1276-1284, 2007. [Journal: Article] [CI: 37] [IF: 2,5]
DOI: 10.1016/j.micinf.2007.06.001 SCOPUS: 35148826082
Damas A., Almeida M., Gales L., Cardoso I., Saraiva M.
Pharmacologic approaches in the treatment of familial amyloidotic polyneuropathy. Sinapse6(1 SUPPL. 1):168-173, 2006. [Journal: Article] [CI: 1]
SCOPUS: 33745382011
Maia F., Almeida M.D.R., Gales L., Kijjoa A., Pinto M.M.M., Saraiva M.J., Damas A.M.
The binding of xanthone derivatives to transthyretin. Biochemical Pharmacology70(12):1861-1869, 2005. [Journal: Article] [CI: 35] [IF: 3,6]
DOI: 10.1016/j.bcp.2005.09.012 SCOPUS: 27744528447
Almeida M., Gales L., Damas A., Cardoso I., Saraiva M.
Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses. Current Drug Targets: CNS and Neurological Disorders4(5):587-596, 2005. [Journal: Review] [CI: 60]
DOI: 10.2174/156800705774322076 SCOPUS: 26844484754
Almeida M., Macedo B., Cardoso I., Valencia G., Arsequell G., Planas A., Saraiva M.
Effects of a new diflunisal derivative on transthyretin binding and stabilization in serum from FAP patients. Amyloid and Amyloidosis:497-499, 2004. [Book: Book Chapter]
SCOPUS: 85057673222
Almeida M., Macedo B., Cardoso I., Alves I., Valencia G., Arsequell G., Planas A., Saraiva M.
Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative. Biochemical Journal381(2):351-356, 2004. [Journal: Article] [CI: 88] [IF: 4,3]
DOI: 10.1042/BJ20040011 SCOPUS: 3242807241
Almeida M., Alves I., Terazaki H., Ando Y., Saraiva M.
Comparative studies of two transthyretin variants with protective effects on familial amyloidotic polyneuropathy: TTR R104H and TTR T119M. Biochemical and Biophysical Research Communications270(3):1024-1028, 2000. [Journal: Article] [CI: 61] [IF: 3,1]
DOI: 10.1006/bbrc.2000.2554 SCOPUS: 0034696835
Ando Y., Almeida M.D.R., Ohlsson P.I., Ando E., Negi A., Suhr O., Terazaki H., Obayashi K., Ando M., Saraiva M.J.M.
Unusual self-association properties of transthyretin Y114C related to familial amyloidotic polyneuropathy: Effects on detection and quantification. Biochemical and Biophysical Research Communications261(2):264-269, 1999. [Journal: Article] [CI: 12] [IF: 3,2]
DOI: 10.1006/bbrc.1999.1048 SCOPUS: 0344069494
Almeida M.R., Damas A.M., Lans M.C., Brouwer A., Saraiva M.J.
Thyroxine binding to transthyretin Met 119: Comparative studies of different heterozygotic carriers and structural analysis. Endocrine6(3):309-315, 1997. [Journal: Article] [CI: 91]
DOI: 10.1007/BF02820508 SCOPUS: 0030885583
Alves I., Altland K., Almeida M., Winter P., Saraiva M.
Screening and biochemical characterization of transthyretin variants in the Portuguese population. Human Mutation9(3):226-233, 1997. [Journal: Article] [CI: 51] [IF: 2,3]
DOI: 10.1002/(SICI)1098-1004(1997)9:3<226::AID-HUMU3>3.0.CO;2-5 SCOPUS: 0030992434
Almeida M., Saraiva M.
Thyroxine binding to transthyretin (TTR) variants - Two variants (TTR Pro 55 and TTR met 111) with a particularly low binding affinity. European Journal of Endocrinology135(2):226-230, 1996. [Journal: Article] [CI: 19]
DOI: 10.1530/eje.0.1350226 SCOPUS: 0029831901
Saraiva M.J.M., Almeida M.R., Alves I.L., Bonifacio M.J., Damas A.M., Palha J.A., Goldsteins G., Lundgren E.
Modulating conformational factors in transthyretin amyloid. CIBA Foundation Symposia(199):47-57, 1996. [Journal: Article] [CI: 9]
SCOPUS: 0030345867
de Fatima Torres M., do Rosário Almeida M., Saraiva M.J.
TTR exon scanning in peripheral neuropathies. Neuromuscular Disorders5(3):187-191, 1995. [Journal: Article] [CI: 19]
DOI: 10.1016/0960-8966(94)00054-D SCOPUS: 0029020077
Saraiva M.J.M., Costa P.P., Almeida M.d.R., Banzhoff A., Altland K., Ferlini A., Rubboli G., Plasmati R., Tassinari C.A., Romeo G., Salvi F.
Familial amyloidotic polyneuropathy: transthyretin (prealbumin) variants in kindreds of Italian origin. Human Genetics80(4):341-343, 1988. [Journal: Article] [CI: 10]
DOI: 10.1007/BF00273648 SCOPUS: 0024232963
Almeida M., Alves I., Sakaki Y., Costa P., Saraiva M.
Prenatal diagnosis of familial amyloidotic polyneuropathy: evidence for an early expression of the associated transthyretin methionine 30. Human Genetics85(6):623-626, 1990. [Journal: Article] [CI: 32]
DOI: 10.1007/BF00193586 SCOPUS: 0025076810
Almeida M., Hesse A., Steinmetz A., Maisch B., Altland K., Linker R., Gawinowicz M., Saraiva M.
Transthyretin Leu 68 in a form of cardiac amyloidosis. Basic Research in Cardiology86(6):567-571, 1991. [Journal: Article] [CI: 40]
DOI: 10.1007/BF02190707 SCOPUS: 0026331577
Saraiva M.J.M., Almeida M.D.R., Alves I.L., Moreira P., Gawinowicz M.A., Costa P.P., Rauh S., Banhzoff A., Altland K.
Molecular analyses of an acidic transthyretin Asn 90 variant. American Journal of Human Genetics48(5):1004-1008, 1991. [Journal: Article] [CI: 31]
SCOPUS: 0025853733
Alves I.L., Almeida M.R., Skare J., Skinner M., Kurose K., Sakaki Y., Costa P.P., Saraiva M.J.M.
Amyloidogenic and non‐amyloidogenic transthyretin Asn 90 variants. Clinical Genetics42(1):27-30, 1992. [Journal: Article] [CI: 11]
DOI: 10.1111/j.1399-0004.1992.tb03131.x SCOPUS: 0026691223
Saraiva M.J.M., Almeida M.D.R., Sherman W., Gawinowicz M., Costa P., Costa P.P., Goodman D.W.S.
A new transthyretin mutation associated with amyloid cardiomyopathy. American Journal of Human Genetics50(5):1027-1030, 1992. [Journal: Article] [CI: 33]
SCOPUS: 0026724677
Almeida M.d.R., Ferlini A., Forabosco A., Gawinowicz M., Costa P.P., Salvi F., Plasmati R., Tassinari C.A., Altland K., Saraiva M.J.
Two transthyretin variants (TTR Ala‐49 and TTR Gln‐89) in two sicilian kindreds with hereditary amyloidosis. Human Mutation1(3):211-215, 1992. [Journal: Article] [CI: 43]
DOI: 10.1002/humu.1380010306 SCOPUS: 0027023491
Almeida M., Lopez‐Andreu F., Munar‐Qués M., Costa P., Saraiva M.
Transthyretin ALA 71: A new transthyretin variant in a Spanish family with familial amyloidotic polyneuropathy. Human Mutation2(5):420-421, 1993. [Journal: Article] [CI: 16]
DOI: 10.1002/humu.1380020516 SCOPUS: 0027495964
López Andreu F.R., Munar-Qués M., Parrilla P., Escribano Soriano J.B., Costa P.P., Costa P.M., Almeida M.R., Pons J.A., Robles R., Sánchez-Bueno F.
Liver transplantation for the treatment of type I familial amyloidotic polyneuropathy. Medicina clinica101(15):581-583, 1993. [Journal: Article] [CI: 8]
SCOPUS: 0039317638
Hesse A., Altland K., Linke R.P., Almeida M.R., Saraiva M.J.M., Steinmetz A., Maisch B.
Cardiac amyloidosis: A review and report of a new transthyretin (prealbumin) variant. British Heart Journal70(2):111-115, 1993. [Journal: Article] [CI: 47]
DOI: 10.1136/hrt.70.2.111 SCOPUS: 0027170502
Alves I.L., Divino C.M., Schussler G.C., Altland K., Almeida M.R., Palha J.A., Coelho T., Costa P.P., Saraiva M.J.M.
Thyroxine binding in a TTR Met 119 kindred. Journal of Clinical Endocrinology and Metabolism77(2):484-488, 1993. [Journal: Article] [CI: 37]
SCOPUS: 0027240115
Almeida M., Saraiva M.
TTR leu 64 in an FAP kindred identified by PCR-RFLP analysis. Amyloid1(3):184-185, 1994. [Journal: Article] [CI: 1]
DOI: 10.3109/13506129409148450 SCOPUS: 0028082978
Almeida M.R., Aoyama-Oishi N., Sakaki Y., Holmgren G., Ulf D., Ferlini A., Salvi F., Munar-Qués M., Benson M.D., Skinner M., Costa P.P., Saraiva M.J.
Haplotype analysis of common transthyretin mutations. Human Genetics96(3):350-354, 1995. [Journal: Article] [CI: 23]
DOI: 10.1007/BF00210422 SCOPUS: 0029116835
