Isabel Cardoso

Molecular Neurobiology

Associate Researcher

Graduated in Biochemistry by the ICBAS and by the Sciences Faculty (FCUP) from Porto Univ in 1995, initiated PhD in 1998 which was successfully concluded in Oct 2002 in Porto Univ. and included work developed in IBMC (Molecular Neurobiology Group) but also in Canada and in Switzerland (Biozentrum, Basel) as an invited researcher.

Isabel Cardoso is an Assistant Professor at ICBAS, University of Porto, and researches the importance of Transthyretin (TTR) in Alzheimer’s Disease (AD). The scientific interests are factors that modulate or can be used to modulate neurodegenerative diseases, communication across brain barriers, and common denominators in protein aggregation disorders.

The team showed that TTR is angiogenic and current interests include the pathological vascular alterations in AD.

Published over 65 papers in international peer-review journals, and 5 book chapters, with over 2900 citations and H index of 31.

3 PhD students and 9 Master students finished their theses under her supervision.

Isabel Cardoso participated in several projects, including projects financed by FCT, by La Marató de TV3, Spain, and by the Foundation Millennium BCP.

Selected Publications

Gião T., Saavedra J., Vieira J.R., Pinto M.T., Arsequell G., Cardoso I.,

Neuroprotection in early stages of Alzheimer’s disease is promoted by transthyretin angiogenic properties. Alzheimer's Research and Therapy13(1):, 2021. [Journal: Article] [CI: 6] [IF: 8,8]
DOI: 10.1186/s13195-021-00883-8 SCOPUS: 85113407514.

Alemi M., Oliveira Â., Tavares S.C., Vieira J.R., Alves M.G., Oliveira P.F., Cardoso I.,

Exploring the physiological role of transthyretin in glucose metabolism in the liver. International Journal of Molecular Sciences22(11):, 2021. [Journal: Article] [CI: 1] [IF: 6,2]
DOI: 10.3390/ijms22116073 SCOPUS: 85107273236.

Moreira G.G., Cantrelle F.X., Quezada A., Carvalho F.S., Cristóvão J.S., Sengupta U., Puangmalai N., Carapeto A.P., Rodrigues M.S., Cardoso I., Fritz G., Herrera F., Kayed R., Landrieu I., Gomes C.M.,

Dynamic interactions and Ca²⁺-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding. Nature Communications12(1):, 2021. [Journal: Article] [CI: 10] [IF: 17,7]
DOI: 10.1038/s41467-021-26584-2 SCOPUS: 85118437711.

Cotrina E.Y., Santos L.M., Rivas J., Blasi D., Leite J.P., Liz M.A., Busquets M.A., Planas A., Prohens R., Gimeno A., Jiménez-Barbero J., Gales L., Llop J., Quintana J., Cardoso I., Arsequell G.,

Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease. European Journal of Medicinal Chemistry226:, 2021. [Journal: Article] [CI: 7] [IF: 7,1]
DOI: 10.1016/j.ejmech.2021.113847 SCOPUS: 85115196147.

Gião T., Saavedra J., Cotrina E., Quintana J., Llop J., Arsequell G., Cardoso I.,

Undiscovered roles for transthyretin: From a transporter protein to a new therapeutic target for Alzheimer’s disease. International Journal of Molecular Sciences21(6):, 2020. [Journal: Review] [CI: 34] [IF: 5,9]
DOI: 10.3390/ijms21062075 SCOPUS: 85082092421.

Rejc L., Gómez-Vallejo V., Rios X., Cossío U., Baz Z., Mujica E., Gião T., Cotrina E.Y., Jiménez-Barbero J., Quintana J., Arsequell G., Cardoso I., Llop J.,

Oral Treatment with Iododiflunisal Delays Hippocampal Amyloid-ß Formation in a Transgenic Mouse Model of Alzheimer's Disease: A Longitudinal in vivo Molecular Imaging Study. Journal of Alzheimer's Disease77(1):99-112, 2020. [Journal: Article] [CI: 4] [IF: 4,5]
DOI: 10.3233/JAD-200570 SCOPUS: 85090505597.

Alemi M., Silva S.C., Santana I., Cardoso I.,

Transthyretin stability is critical in assisting beta amyloid clearance– Relevance of transthyretin stabilization in Alzheimer's disease. CNS Neuroscience and Therapeutics23(7):605-619, 2017. [Journal: Article] [CI: 34] [IF: 3,5]
DOI: 10.1111/cns.12707 SCOPUS: 85020073562.