José C. Machado (JCM) is Associate Professor in the Faculty of Medicine of Porto, vice-president of the Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), and Coordinator of the Cancer program at i3S. He studied Biology at the University of Porto and developed his PhD in the Universities of Tubingen, Germany and Porto, Portugal. The scientific question that drives JCM's research group is how genetically encoded information in cancer cells is shared among the diverse cellular constituents of a tumor, and how that affects the heterogeneity and plasticity of cancer cells. JCM has been awarded research projects by the Portuguese Foundation for Science and Technology (FCT), by the Portuguese Agency for Innovation (ADI), by the Portuguese Ministry of Health, by Worldwide Cancer Research and by the European Union. JCM is also the head of R&D at the molecular genetics laboratory of the IPATIMUP Diagnostics Unit. This laboratory is accredited by the College of American Pathologists (CAP), ISO15189:2014 and ISO17025:2005. This is one of the reference laboratories in Portugal for the detection of cancer biomarkers, genetic diagnosis of hereditary cancer syndromes and pathology. As of May 2020, JCM (Scopus Author ID 7102792651) co-authors 163 peer-reviewed publications in international journals, with 10591 total citations, and with an h-index of 42.