Where Ideas grow
Flávia Castro
Research Scientist

Flávia Castro completed her PhD in Cellular and Molecular Biotechnology in 2019 by Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto in collaboration with Ghent University Hospital, Belgium. She did a MSc in Health Sciences in 2014 by Escola de Mecidina, Universidade do Minho and a Bachelor in Biochemistry in 2012 by Escola de Ciências, Universidade do Minho.

Actually, Flávia is a Junior Researcher at Nanomedicines & Translational Drug Delivery. Her scientific interests are related to tumor microenvironment, immune modulation and nanomedicine. She has been focused on targeting immune cells and reprograming them through nanoparticles to test in vitro and in vivo tumor models. Flávia is Ambassador of European Association for Cancer Research since 2017.

Selected Publications

Castro F., Cardoso A.P., Gonçalves R.M., Serre K., Oliveira M.J.,
Interferon-gamma at the crossroads of tumor immune surveillance or evasion. Frontiers in Immunology9(MAY):, 2018. [Journal: Review] [CI: 173] [IF: 4,7]
DOI: 10.3389/fimmu.2018.00847 SCOPUS: 85046686322.

Castro F., Pinto M.L., Silva A.M., Pereira C.L., Teixeira G.Q., Gomez-Lazaro M., Santos S.G., Barbosa M.A., Gonçalves R.M., Oliveira M.J.,
Pro-inflammatory chitosan/poly(γ-glutamic acid) nanoparticles modulate human antigen-presenting cells phenotype and revert their pro-invasive capacity. Acta Biomaterialia63:96-109, 2017. [Journal: Article] [CI: 19] [IF: 6,4]
DOI: 10.1016/j.actbio.2017.09.016 SCOPUS: 85030032238.

Teixeira G.Q., Leite Pereira C., Castro F., Ferreira J.R., Gomez-Lazaro M., Aguiar P., Barbosa M.A., Neidlinger-Wilke C., Goncalves R.M.,
Anti-inflammatory Chitosan/Poly-γ-glutamic acid nanoparticles control inflammation while remodeling extracellular matrix in degenerated intervertebral disc. Acta Biomaterialia42:168-179, 2016. [Journal: Article] [CI: 35] [IF: 6,3]
DOI: 10.1016/j.actbio.2016.06.013 SCOPUS: 84983262266.

Moreira-Teixeira L., Sousa J., McNab F.W., Torrado E., Cardoso F., Machado H., Castro F., Cardoso V., Gaifem J., Wu X., Appelberg R., Castro A.G., O'Garra A., Saraiva M.,
Type i IFN inhibits alternative macrophage activation during mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-γ signaling. Journal of Immunology197(12):4714-4726, 2016. [Journal: Article] [CI: 50] [IF: 4,9]
DOI: 10.4049/jimmunol.1600584 SCOPUS: 85002328285.

Cardoso A.P., Gonçalves R.M., Antunes J.C., Pinto M.L., Pinto A.T., Castro F., Monteiro C., Barbosa M.A., Oliveira M.J.,
An interferon-γ-delivery system based on chitosan/poly(γ-glutamic acid) polyelectrolyte complexes modulates macrophage-derived stimulation of cancer cell invasion in vitro. Acta Biomaterialia23:157-171, 2015. [Journal: Article] [CI: 25] [IF: 6]
DOI: 10.1016/j.actbio.2015.05.022 SCOPUS: 84938199069.

Cardoso F., Castro F., Moreira-Teixeira L., Sousa J., Torrado E., Silvestre R., Castro A.G., Saraiva M., Pais T.F.,
Myeloid sirtuin 2 expression does not impact long-term Mycobacterium tuberculosis control. PLoS ONE10(7):, 2015. [Journal: Article] [CI: 9] [IF: 3,1]
DOI: 10.1371/journal.pone.0131904 SCOPUS: 84940426429.

Castro F., Pinto M.L., Almeida R., Pereira F., Silva A.M., Pereira C.L., Santos S.G., Barbosa M.A., Gonçalves R.M., Oliveira M.J.,
Chitosan/poly(γ-glutamic acid) nanoparticles incorporating IFN-γ for immune response modulation in the context of colorectal cancer. Biomaterials Science7(8):3386-3403, 2019. [Journal: Article] [CI: 9] [IF: 6,2]
DOI: 10.1039/c9bm00393b SCOPUS: 85069760890.