Where Ideas grow
Renata CarriƧo
Renata Bordeira Carriço graduated in Biology from Faculdade de Ciências da Universidade de Lisboa. She holds a Master in Human Biology and Environment from the same university, a work developed under the supervision of Doctor Jacinta Serpa at Centro de Investigação de Patobiologia Molecular do Instituto Português de Oncologia de Lisboa Francisco Gentil (CIPM-IPOLFG), about the study of somatic mutations in the APC gene in patients with early onset colorectal cancer. Renata moved then into Doctor Carla Oliveira?s group at Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), with a FCT research fellowship. Later, under the supervision of Doctor Carla Oliveira, she obtained a PhD in Biomedicine, by Faculdade de Medicina da Universidade do Porto, with the project ?Suppressor-tRNAs as therapeutic tools for cancer associated syndromes: HDGC as a model system?, in collaboration with Doctor Ana Paula Pêgo from Instituto de Engenharia Biomédica (INEB) and Doctor Manuel Santos from Universidade de Aveiro. This work was focused on the role of E-cadherin as cancer initiator in HDGC, and the possibility of using suppressor-tRNAs to restore the expression of normal E-cadherin from a CDH1 gene carrying a nonsense mutation. As a result from her PhD work, Renata is first author in two articles that have resulted from her PhD work, one published in Trends in Molecular Medicine, which has made the cover of this journal, and the other in European Journal of Human Genetics. Moreover, her participation in other projects of Carla Oliveira?s lab rendered her co-authorship in other papers published in journals such as Human Molecular Genetics and Gastroenterology. Since February 2014, Renata holds a post-doctoral fellowship in Doctor Jose Bessa?s lab, at Instituto de Biologia Molecular e Celular (IBMC). She is currently interested in studying mechanisms regulating the expression of key-genes involved in pancreas development and pancreatic cancer, using zebrafish as a model, with particular focus on the role of cis-regulatory elements in disease. She has been recently awarded with an EMBO short-term fellowship to develop part of her project in Doctor Jose Bessa?s lab in collaboration with Doctor Jose Luis Gomez-Skarmeta, from Centro Andaluz de Biología del Desarrollo (CABD), Seville.