The X-ray Crystallography platform provides access to state-of-the-art facilities and instrumentation for crystallization and crystallographic data collection of small molecules and macromolecules.

The X-ray Crystallography platform comprises two different working areas:

1. The crystallization facility, with two dedicated temperature-controlled chambers, complemented by a crystallization robot with lipidic cubic phase attachment;
2. The X-ray diffraction room, equipped with a four-circle single-crystal X-ray diffractometer and sample cryostat.

• Crystallization of small molecules
• Crystallization of biomolecules and biomolecular complexes, including membrane proteins
• Crystallographic data collection and processing from small molecule crystals
• Crystallographic data collection and processing from biomolecular crystals
• Optimization of cryoprotection conditions

1. Dual walk-in temperature-controlled crystallization chambers (4 °C and 20 °C)

2. Douglas Instruments Oryx4 LCP crystallization robot:
   1. sub-microliter scale (minimum 100 nL) setups in 96-well format
   2.  sitting-drop, hanging-drop, and microbatch configurations
   3. random and regular microseeding
   4. LCP dispensing with lipidic cubic phase attachment

3. Rigaku/Oxford Diffraction Gemini PX Ultra single-crystal X-ray diffractometer
   1. Dual X-ray source (wavelength switching can be performed in as little as 15 minutes, for increased flexibility):
      1. Enhance Mo Ka with channel cut graphite monochromator
      2. Enhance Ultra Cu Ka with multi-layer optics
4. 2. Four-circle high angular resolution (0.37 Å for Mo, 0.78 Å for Cu) kappa goniostat
   3. Onyx CCD 165 mm area detector.

4. Oxford Cryosystems Cryostream 700 sample cryostat.

The X-ray Crystallography platform has an open-access policy and its resources are available to both the scientific community and the industry. Please contact us for access fees.

Two access modes are available:

1. Equipment use only
   1. Upon mandatory training (provided on demand), users can book and use the X-ray Crystallography platform equipment at their own convenience.

2. Contract services
   1. The X-ray Crystallography platform can provide an integrated service for the structural characterization of samples: crystallization, diffraction data collection, structure determination, and structural interpretation. Detailed cost estimates are provided on a per case basis.

The X-ray Crystallography platform is only accessible to trained users. Specialised training is provided on demand.

The platform is regularly involved in graduate training (GABBA and PDBMC PhD programs).