Where Ideas Grow
Ana Pedrosa
Post-doctoral Fellow

Ana Pedrosa has a BSc (2014) and MSc (2016) in Biochemistry by Universidade do Porto (Portugal). During the MSc degree she joined the Organelle Biogenesis and Function Group laboratory to work on the functional/structural relationship of the main peroxisomal matrix protein receptor, PEX5. Next, Ana obtained her PhD in Biomedical Sciences by ICBAS-UP with work regarding the mechanism used by the AAA ATPases PEX1 and PEX6 to extract ubiquitinated PEX5 from the peroxisomal membrane. Currently, she keeps using her molecular biology and biochemistry expertises combined with novel techniques to better understand the mechanisms underlying human peroxisomal disorders.

Selected Publications

Pedrosa A.G., Francisco T., Rodrigues T.A., Ferreira M.J., van der Heden van Noort G.J., Azevedo J.E.,
The Extraction Mechanism of Monoubiquitinated PEX5 from the Peroxisomal Membrane. Journal of Molecular Biology435(2):, 2023. [Journal: Article] [CI: 4] [IF: 5,6 (*)]
DOI: 10.1016/j.jmb.2022.167896 SCOPUS: 85145598058.

Pedrosa A.G., Francisco T., Bicho D., Dias A.F., Barros-Barbosa A., Hagmann V., Dodt G., Rodrigues T.A., Azevedo J.E.,
Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol. Journal of Biological Chemistry293(29):11553-11563, 2018. [Journal: Article] [CI: 31] [IF: 4,1]
DOI: 10.1074/jbc.RA118.003669 SCOPUS: 85050390152.

Pedrosa A.G., Francisco T., Ferreira M.J., Rodrigues T.A., Barros-Barbosa A., Azevedo J.E.,
A mechanistic perspective on pex1 and pex6, two aaa+ proteins of the peroxisomal protein import machinery. International Journal of Molecular Sciences20(21):, 2019. [Journal: Review] [CI: 6] [IF: 4,6]
DOI: 10.3390/ijms20215246 SCOPUS: 85074140684.

Ferreira M.J., Rodrigues T.A., Pedrosa A.G., Gales L., Salvador A., Francisco T., Azevedo J.E.,
The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis. Redox Biology63:, 2023. [Journal: Article] [CI: 6] [IF: 11,4 (*)]
DOI: 10.1016/j.redox.2023.102764 SCOPUS: 85160316858.

Barros-Barbosa A., Rodrigues T.A., Ferreira M.J., Pedrosa A.G., Teixeira N.R., Francisco T., Azevedo J.E.,
The intrinsically disordered nature of the peroxisomal protein translocation machinery. FEBS Journal286(1):24-38, 2019. [Journal: Article] [CI: 18] [IF: 4,4]
DOI: 10.1111/febs.14704 SCOPUS: 85057835122.