Where Ideas Grow
Marta Teixeira Pinto
Platform Head
Marta Teixeira Pinto (MT Pinto) is responsible for the ?in vivo CAM assays? unit at Ipatimup/I3S which provides custom-made in vivo assays using the chick embryo chorioallantoic membrane (CAM) model. She graduated in Biochemistry (FCUP, 1999), completed her MSc degree in Neurosciences (FMUL, 2001) and obtained her PhD in ?Human Biology? (FMUP, 2008). MT Pinto joined Ipatimup as an Investigator (Ciência2008) of the Cancer Genetics Group and was mainly dedicated to study cancer angiogenesis, invasion and metastasis, using an animal model that fulfills the 3Rs principals. MT Pinto is author in several publications within her subject of interest using different tumour models (24 papers with more than 230 citations and h-Index=10). After setting up the laboratory and implementing several important assays, in 2012 MT Pinto established the ?In vivo CAM assays? unit. MT Pinto has developed skills in entrepreneurship, innovation and IP protection throughout her scientific career.

Selected Publications

Ferreira L.B., Tavares C., Pestana A., Pereira C.L., Eloy C., Pinto M.T., Castro P., Batista R., Rios E., Sobrinho-Simões M., Pereira Gimba E.R., Soares P.,
Osteopontin-a splice variant is overexpressed in papillary thyroid carcinoma and modulates invasive behavior. Oncotarget7(32):52003-52016, 2016. [Journal: Article] [CI: 20] [IF: 5,2]
DOI: 10.18632/oncotarget.10468 SCOPUS: 84982293109.

Almeida M.I., Silva A.M., Vasconcelos D.M., Almeida C.R., Caires H., Pinto M.T., Calin G.A., Santos S.G., Barbosa M.A.,
miR-195 in human primary mesenchymal stromal/stem cells regulates proliferation, osteogenesis and paracrine effect on angiogenesis. Oncotarget7(1):7-22, 2016. [Journal: Article] [CI: 47] [IF: 5,2]
DOI: 10.18632/ONCOTARGET.6589 SCOPUS: 84969765513.

Estrada M.F., Rebelo S.P., Davies E.J., Pinto M.T., Pereira H., Santo V.E., Smalley M.J., Barry S.T., Gualda E.J., Alves P.M., Anderson E., Brito C.,
Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression. Biomaterials78:50-61, 2016. [Journal: Article] [CI: 73] [IF: 8,4]
DOI: 10.1016/j.biomaterials.2015.11.030 SCOPUS: 84949946054.

Simões-correia J., Silva D.I., Melo S., Figueiredo J., Caldeira J., Pinto M.T., Girão H., Pereira P., Seruca R.,
DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo. Human Molecular Genetics23(8):2094-2105, 2014. [Journal: Article] [CI: 14] [IF: 6,4]
DOI: 10.1093/hmg/ddt602 SCOPUS: 84897831766.

Caldeira J., Simões-Correia J., Paredes J., Pinto M.T., Sousa S., Corso G., Marrelli D., Roviello F., Pereira P.S., Weil D., Oliveira C., Casares F., Seruca R.,
CPEB1, a novel gene silenced in gastric cancer: A Drosophila approach. Gut61(8):1115-1123, 2012. [Journal: Article] [CI: 38] [IF: 10,7]
DOI: 10.1136/gutjnl-2011-300427 SCOPUS: 84863719147.

Pinheiro H., Carvalho J., Oliveira P., Ferreira D., Pinto M.T., Osório H., Licastro D., Bordeira-carriço R., Jordan P., Lazarevic D., Sanges R., Stupka E., Huntsman D., Seruca R., Oliveira C.,
Transcription initiation arising from E-cadherin/CDH1 intron2: A novel protein isoform that increases gastric cancer cell invasion and angiogenesis. Human Molecular Genetics21(19):4253-4269, 2012. [Journal: Article] [CI: 14] [IF: 7,7]
DOI: 10.1093/hmg/dds248 SCOPUS: 84866408689.

Gomes C., Osório H., Pinto M.T., Campos D., Oliveira M.J., Reis C.A.,
Expression of ST3GAL4 Leads to SLex Expression and Induces c-Met Activation and an Invasive Phenotype in Gastric Carcinoma Cells. PLoS ONE8(6):, 2013. [Journal: Article] [CI: 64] [IF: 3,5]
DOI: 10.1371/journal.pone.0066737 SCOPUS: 84879165131.