Where Ideas Grow
Isabel Martins
Pain Neurobiology
Junior Researcher
In 2003 obtention of the MSc degree in ?Sciences et Techniques du Vivant option Génie Biologique?, Conservatoire National des Arts et Métiers, Paris, France. In 2012 obtention of Ph.D. degree in Neuroscience, Faculty of Medicine of Porto, Portugal. Working in Neurobiology of pain since 2003. Current research interest: Pain mechanisms, neuropathic pain, study of neurotransmitter release by microdialysis in the brain, gene transfer in the central nervous system. Other professional activities: Assistant Professor of Cellular and Molecular Biology, 1st year of medical curriculum, Faculty of Medicine of Porto.

Selected Publications

Pereira-Silva R., Serrão P., Lourença Neto F., Martins I.,
Diffuse noxious inhibitory controls in chronic joint inflammatory Pain: Study of the descending serotonergic modulation mediated through 5HT3 receptors. Neurobiology of Pain13:, 2023. [Journal: Article]
DOI: 10.1016/j.ynpai.2023.100123 SCOPUS: 85149336937.


Sampaio-Cunha T.J., Martins I.,
Knowing the Enemy Is Halfway towards Victory: A Scoping Review on Opioid-Induced Hyperalgesia. Journal of Clinical Medicine11(20):, 2022. [Journal: Review] [CI: 6] [IF: 3,9]
DOI: 10.3390/jcm11206161 SCOPUS: 85140724282.


Tavares I., Costa-Pereira J.T., Martins I.,
Monoaminergic and Opioidergic Modulation of Brainstem Circuits: New Insights Into the Clinical Challenges of Pain Treatment?. Frontiers in Pain Research2:, 2021. [Journal: Short Survey] [CI: 9]
DOI: 10.3389/fpain.2021.696515 SCOPUS: 85122956821.


Pereira-Silva R., Costa-Pereira J.T., Alonso R., Serrão P., Martins I., Neto F.L.,
Attenuation of the diffuse noxious inhibitory controls in chronic joint inflammatory pain is accompanied by anxiodepressive-like behaviors and impairment of the descending noradrenergic modulation. International Journal of Molecular Sciences21(8):, 2020. [Journal: Article] [CI: 9] [IF: 5,9]
DOI: 10.3390/ijms21082973 SCOPUS: 85083835689.


Costa A.R., Sousa M., Wilson S.P., Reguenga C., Teixeira-Pinto A., Tavares I., Martins I.,
Shift of µ-opioid Receptor Signaling in the Dorsal Reticular Nucleus Is Implicated in Morphine-induced Hyperalgesia in Male Rats. Anesthesiology133(3):628-644, 2020. [Journal: Article] [CI: 8] [IF: 7,9]
DOI: 10.1097/ALN.0000000000003412 SCOPUS: 85089414988.


Costa-Pereira J.T., Serrão P., Martins I., Tavares I.,
Serotoninergic pain modulation from the rostral ventromedial medulla (RVM) in chemotherapy-induced neuropathy: The role of spinal 5-HT3 receptors. European Journal of Neuroscience51(8):1756-1769, 2020. [Journal: Article] [CI: 25] [IF: 3,4]
DOI: 10.1111/ejn.14614 SCOPUS: 85076114190.


Costa A.R., Carvalho P., Flik G., Wilson S.P., Reguenga C., Martins I., Tavares I.,
Neuropathic pain induced alterations in the opioidergic modulation of a descending pain facilitatory area of the brain. Frontiers in Cellular Neuroscience13:, 2019. [Journal: Article] [CI: 9] [IF: 3,9]
DOI: 10.3389/fncel.2019.00287 SCOPUS: 85068487441.


Martins I., Tavares I.,
Reticular formation and pain: The past and the future. Frontiers in Neuroanatomy11:, 2017. [Journal: Article] [CI: 67] [IF: 3,2]
DOI: 10.3389/fnana.2017.00051 SCOPUS: 85029141878.


Martins I., Carvalho P., De Vries M.G., Teixeira-Pinto A., Wilson S.P., Westerink B.H.C., Tavares I.,
GABA acting on GABAB receptors located in a medullary pain facilitatory area enhances nociceptive behaviors evoked by intraplantar formalin injection. Pain156(8):1555-1565, 2015. [Journal: Article] [CI: 12] [IF: 5,6]
DOI: 10.1097/j.pain.0000000000000203 SCOPUS: 84945259029.


Martins I., Carvalho P., de Vries M.G., Teixeira-Pinto A., Wilson S.P., Westerink B.H.C., Tavares I.,
Increased noradrenergic neurotransmission to a pain facilitatory area of the brain is implicated in facilitation of chronic pain. Anesthesiology123(3):642-653, 2015. [Journal: Article] [CI: 31] [IF: 5,3]
DOI: 10.1097/ALN.0000000000000749 SCOPUS: 84946912857.