Where Ideas Grow
Fábio Júnio Ferreira
Junior Researcher

Fábio Júnio Ferreira is a Junior Researcher at the Vertebrate Development and Regeneration Group, at i3S. His work explores the function of non-coding DNA sequences in the activity of cis-regulatory elements, gene expression and physiology through the combined used of genome editing, cell and molecular biology, and bioinformatic tools. He is an alumni of the GABBA PhD Program, from the University of Porto, having worked mainly on the role of transcriptional cis regulation and function of FoxM1, a transcription factor involved in cell cycle progression, in apoptosis and senescence, using primary human cells and zebrafish. Fábio holds a Bachelor's degree in Applied Biology from the University of Minho, Braga, having worked on the genomics, proteomics and adaptive traits of bacteria. He developed his year-long Master's project at the Institute of Integrative Biology, at the University of Liverpool, where he tested novel putative life-extending drugs and explored the molecular and genetic mechanisms regulating their effects, in C. elegans mutants. Through his work, Fábio hopes to contribute to the elucidation of ageing-associated processes behind tissue-specific decrease of function and disease.

Selected Publications

Bordeira-Carriço R., Teixeira J., Duque M., Galhardo M., Ribeiro D., Acemel R.D., Firbas P.N., Tena J.J., Eufrásio A., Marques J., Ferreira F.J., Freitas T., Carneiro F., Goméz-Skarmeta J.L., Bessa J.,
Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers. Nature Communications13(1):, 2022. [Journal: Article] [CI: 3] [IF: 16,6]
DOI: 10.1038/s41467-022-29551-7 SCOPUS: 85128076921.


Vaz S., Ferreira F.J., Macedo J.C., Leor G., Ben-David U., Bessa J., Logarinho E.,
FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation. Cell Death and Disease12(6):, 2021. [Journal: Article] [CI: 9] [IF: 9,7]
DOI: 10.1038/s41419-021-03822-5 SCOPUS: 85106857863.


Sousa F., Costa-Pereira A.I., Cruz A., Ferreira F.J., Gouveia M., Bessa J., Sarmento B., Travasso R.D.M., Mendes Pinto I.,
Intratumoral VEGF nanotrapper reduces gliobastoma vascularization and tumor cell mass. Journal of Controlled Release339:381-390, 2021. [Journal: Article] [CI: 12] [IF: 11,5]
DOI: 10.1016/j.jconrel.2021.09.031 SCOPUS: 85116870935.


Ferreira F.J., Carvalho L., Logarinho E., Bessa J.,
Foxm1 modulates cell non-autonomous response in zebrafish skeletal muscle homeostasis. Cells10(5):, 2021. [Journal: Article] [CI: 6] [IF: 7,7]
DOI: 10.3390/cells10051241 SCOPUS: 85107456993.


Eufrásio A., Perrod C., Ferreira F.J., Duque M., Galhardo M., Bessa J.,
In vivo reporter assays uncover changes in enhancer activity caused by type 2 diabetes–associated single nucleotide polymorphisms. Diabetes69(12):2794-2805, 2020. [Journal: Article] [CI: 2] [IF: 9,5]
DOI: 10.2337/db19-1049 SCOPUS: 85096579124.