Cláudia Martins concluded her PhD in Biomedical Sciences from University of Porto (Portugal) in 2023, under a partnership with the University of Nottingham (UK) and University of Louvain (Belgium), and is currently a Junior Postdoctoral Researcher at Institute for Research and Innovation in Health (i3S) under the EU-funded GENEGUT project. In recent years, Cláudia Martins has taken on the role of visiting researcher at different academia (ETH Zurich (Switzerland), Queen's University Belfast (UK), University of Nottingham (UK), University of Louvain (Belgium)) and industrial (MyBiotech GmbH (Germany)) institutions. Some of her current areas of interest include biomaterials, targeted cancer nanomedicine, brain drug delivery and tissue engineering. Cláudia Martins has developed an extensive work in these areas since 2015, which resulted in a Marie Sklodowska-Curie Fellowship, participation in 7 R&D projects, and a Co-PI grant scheme funded by the UK Engineering and Physical Sciences Research Council (EPSRC). She has so far published >20 articles in international peer reviewed journals (first-author, last-author, co-author) and 5 book chapters, authored >40 communications in international conferences and was awarded 22 distinctions (including the prestigious 2023 Galenus Technology Prize and the 2019 Nano2Clinic COST Action Early Career Investigator Award). The scientific journey of Cláudia Martins has involved her participation in various societies (e.g., Controlled Release Society (CRS), American Association for Cancer Research, European Association for Cancer Research), technical committee activities (e.g., current Chair of the CRS Young Scientist Committee), and outreach initiatives (co-coordination of Pint of Science Portugal).
Selected Publications
Stimuli-Responsive Multifunctional Nanomedicine for Enhanced Glioblastoma Chemotherapy Augments Multistage Blood-to-Brain Trafficking and Tumor Targeting. Small19(22):, 2023. [Journal: Article] [CI: 17] [IF: 13]
DOI: 10.1002/smll.202300029 SCOPUS: 85149319530
Martins C., Pacheco C., Moreira-Barbosa C., Marques-Magalhães Â., Dias S., Araújo M., Oliveira M.J., Sarmento B.
Glioblastoma immuno-endothelial multicellular microtissue as a 3D in vitro evaluation tool of anti-cancer nano-therapeutics. Journal of Controlled Release353:77-95, 2023. [Journal: Article] [CI: 8] [IF: 10.5]
DOI: 10.1016/j.jconrel.2022.11.024 SCOPUS: 85143777496
Martins C., Sarmento B.
Multi-ligand functionalized blood-to-tumor sequential targeting strategies in the field of glioblastoma nanomedicine. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology15(5):, 2023. [Journal: Review] [CI: 3] [IF: 6.9]
DOI: 10.1002/wnan.1893 SCOPUS: 85160576752
Martins C., Pacheco C., Faria P., Sarmento B.
Nanomedicine approaches for treating glioblastoma. Nanomedicine18(18):1135-1138, 2023. [Journal: Editorial] [IF: 4.7]
DOI: 10.2217/nnm-2023-0163 SCOPUS: 85173236691
Faria P., Pacheco C., Moura R.P., Sarmento B., Martins C.
Multifunctional nanomedicine strategies to manage brain diseases. Drug Delivery and Translational Research13(5):1322-1342, 2023. [Journal: Article] [CI: 8] [IF: 5.7]
DOI: 10.1007/s13346-022-01256-w SCOPUS: 85141513690
Macedo-Pereira A., Martins C., Lima J., Sarmento B.
Digging the intercellular crosstalk via extracellular vesicles: May exosomes be the drug delivery solution for target glioblastoma?. Journal of Controlled Release358:98-115, 2023. [Journal: Review] [CI: 17] [IF: 10.5]
DOI: 10.1016/j.jconrel.2023.04.038 SCOPUS: 85153896114
Silveira M.J., Martins C., Cruz T., Castro F., Amorim-Costa Â., Chester K., Oliveira M.J., Sarmento B.
scFv biofunctionalized nanoparticles to effective and safe targeting of CEA-expressing colorectal cancer cells. Journal of Nanobiotechnology21(1):, 2023. [Journal: Article] [CI: 6] [IF: 10,2 (*)]
DOI: 10.1186/s12951-023-02126-4 SCOPUS: 85173053738
Moura R.P., Carvalho E.D., Martins C., des Rieux A., Pêgo A.P., Sarmento B.
Functionalized retinoic acid lipid nanocapsules promotes a two-front attack on inflammation and lack of demyelination on neurodegenerative disorders. Journal of Controlled Release358:43-58, 2023. [Journal: Article] [CI: 7] [IF: 10.5]
DOI: 10.1016/j.jconrel.2023.04.034 SCOPUS: 85153574869
Castro F., Martins C., Silveira M.J., Moura R.P., Pereira C.L., Sarmento B.
Advances on erythrocyte-mimicking nanovehicles to overcome barriers in biological microenvironments. Advanced Drug Delivery Reviews170:312-339, 2021. [Journal: Review] [CI: 45] [IF: 17,9]
DOI: 10.1016/j.addr.2020.09.001 SCOPUS: 85091211887
Garizo A.R., Castro F., Martins C., Almeida A., Dias T.P., Fernardes F., Barrias C.C., Bernardes N., Fialho A.M., Sarmento B.
p28-functionalized PLGA nanoparticles loaded with gefitinib reduce tumor burden and metastases formation on lung cancer. Journal of Controlled Release337:329-342, 2021. [Journal: Article] [CI: 39] [IF: 11,5]
DOI: 10.1016/j.jconrel.2021.07.035 SCOPUS: 85111295172
de Castro R.R., do Carmo F.A., Martins C., Simon A., de Sousa V.P., Rodrigues C.R., Cabral L.M., Sarmento B.
Clofazimine functionalized polymeric nanoparticles for brain delivery in the tuberculosis treatment. International Journal of Pharmaceutics602:, 2021. [Journal: Article] [CI: 26] [IF: 6,5]
DOI: 10.1016/j.ijpharm.2021.120655 SCOPUS: 85105332294
Martins C., Chauhan V.M., Araújo M., Abouselo A., Barrias C.C., Aylott J.W., Sarmento B.
Advanced polymeric nanotechnology to augment therapeutic delivery and disease diagnosis. Nanomedicine15(23):2287-2309, 2020. [Journal: Review] [CI: 5] [IF: 5,3]
DOI: 10.2217/nnm-2020-0145 SCOPUS: 85093891701
Martins C., Chauhan V.M., Selo A.A., Al-Natour M., Aylott J.W., Sarmento B.
Modelling protein therapeutic co-formulation and co-delivery with PLGA nanoparticles continuously manufactured by microfluidics. Reaction Chemistry and Engineering5(2):308-319, 2020. [Journal: Article] [CI: 11] [IF: 4,2]
DOI: 10.1039/c9re00395a SCOPUS: 85079359438
Martins C., Araújo F., Gomes M.J., Fernandes C., Nunes R., Li W., Santos H.A., Borges F., Sarmento B.
Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy. European Journal of Pharmaceutics and Biopharmaceutics138:111-124, 2019. [Journal: Article] [CI: 68] [IF: 4,6]
DOI: 10.1016/j.ejpb.2018.01.014 SCOPUS: 85041597622
Chen C., Tang J., Gu Y., Liu L., Liu X., Deng L., Martins C., Sarmento B., Cui W., Chen L.
Bioinspired Hydrogel Electrospun Fibers for Spinal Cord Regeneration. Advanced Functional Materials29(4):, 2019. [Journal: Article] [CI: 175] [IF: 16,8]
DOI: 10.1002/adfm.201806899 SCOPUS: 85057722014
Benfeito S., Oliveira C., Fernandes C., Cagide F., Teixeira J., Amorim R., Garrido J., Martins C., Sarmento B., Silva R., Remião F., Uriarte E., Oliveira P.J., Borges F.
Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction. European Journal of Medicinal Chemistry167:525-545, 2019. [Journal: Article] [CI: 33] [IF: 5,6]
DOI: 10.1016/j.ejmech.2019.01.055 SCOPUS: 85061639088
Moura R.P., Martins C., Pinto S., Sousa F., Sarmento B.
Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology. Expert Opinion on Drug Delivery16(3):271-285, 2019. [Journal: Review] [CI: 98] [IF: 4,8]
DOI: 10.1080/17425247.2019.1583205 SCOPUS: 85063003421
Cayero-Otero M.D., Gomes M.J., Martins C., Álvarez-Fuentes J., Fernández-Arévalo M., Sarmento B., Martín-Banderas L.
In vivo biodistribution of venlafaxine-PLGA nanoparticles for brain delivery: plain vs. functionalized nanoparticles. Expert Opinion on Drug Delivery16(12):1413-1427, 2019. [Journal: Article] [CI: 36] [IF: 4,8]
DOI: 10.1080/17425247.2019.1690452 SCOPUS: 85076396295
Martins C., Sousa F., Araújo F., Sarmento B.
Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications. Advanced Healthcare Materials7(1):, 2018. [Journal: Review] [CI: 266] [IF: 6,3]
DOI: 10.1002/adhm.201701035 SCOPUS: 85035072701
Araújo F., Martins C., Azevedo C., Sarmento B.
Chemical modification of drug molecules as strategy to reduce interactions with mucus. Advanced Drug Delivery Reviews124:98-106, 2018. [Journal: Review] [CI: 51] [IF: 15,5]
DOI: 10.1016/j.addr.2017.09.020 SCOPUS: 85044646570
Fernandes C., Martins C., Fonseca A., Nunes R., Matos M.J., Silva R., Garrido J., Sarmento B., Remião F., Otero-Espinar F.J., Uriarte E., Borges F.
PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor. ACS Applied Materials and Interfaces10(46):39557-39569, 2018. [Journal: Article] [CI: 48] [IF: 8,5]
DOI: 10.1021/acsami.8b17224 SCOPUS: 85056493201
Fernandes C., Pinto M., Martins C., Gomes M.J., Sarmento B., Oliveira P.J., Remião F., Borges F.
Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood-Brain Barrier. Bioconjugate Chemistry29(5):1677-1689, 2018. [Journal: Article] [CI: 31] [IF: 4,3]
DOI: 10.1021/acs.bioconjchem.8b00151 SCOPUS: 85047195982