Hugo Osório
Proteomics
Team Coordinator
Hugo Osorio graduated in Biochemistry (1999) and holds a PhD in Biomedical Sciences (2004) from the University of Porto. His research focuses on the development and application of mass-spectrometry based proteomics approaches in biomedicine with a focus on cancer proteomics and glycosylation profiling. Hugo Osorio is the Head of the i3S Proteomics Scientific Platform and Professor at University of Porto. He is member of the board of the Portuguese Proteomics Association – ProCura and manages the i3S node of the Portuguese Mass Spectrometry Network- RNEM integrated in the FCT Research Infrastructures RoadMap. He organizes and participates in pre and postgraduate mass spectrometry and proteomics courses. As of January 2024, Hugo Osorio has 95 publications in international peer-reviewed journals and three book chapters. His research work has over 3300 citations and with an h-index of 26 (Scopus).
Selected Publications
Osório H., Silva C., Ferreira M., Gullo I., Máximo V., Barros R., Mendonça F., Oliveira C., Carneiro F.,
Poças J., Marques C., Gomes C., Otake A.H., Pinto F., Ferreira M., Silva T., Faria-Ramos I., Matos R., Ribeiro A.R., Senra E., Cavadas B., Batista S., Maia J., Macedo J.A., Lima L., Afonso L.P., Ferreira J.A., Santos L.L., Polónia A., Osório H., Belting M., Reis C.A., Costa-Silva B., Magalhães A.,
Martins Á.M., Lopes T.M., Diniz F., Pires J., Osório H., Pinto F., Freitas D., Reis C.A.,
Zhang H., Freitas D., Kim H.S., Fabijanic K., Li Z., Chen H., Mark M.T., Molina H., Martin A.B., Bojmar L., Fang J., Rampersaud S., Hoshino A., Matei I., Kenific C.M., Nakajima M., Mutvei A.P., Sansone P., Buehring W., Wang H., Jimenez J.P., Cohen-Gould L., Paknejad N., Brendel M., Manova-Todorova K., Magalhães A., Ferreira J.A., Osório H., Silva A.M., Massey A., Cubillos-Ruiz J.R., Galletti G., Giannakakou P., Cuervo A.M., Blenis J., Schwartz R., Brady M.S., Peinado H., Bromberg J., Matsui H., Reis C.A., Lyden D.,
Ruivo C.F., Bastos N., Adem B., Batista I., Duraes C., Melo C.A., Castaldo S.A., Campos-Labori F., Moutinho-Ribeir P., Morão B., Costa-Pint A., Silva S., Osorio H., Ciordia S., Costa J.L., Goodrich D., Cavadas B., Pereira L., Kouzarides T., MacEdo G., Maio R., Carneiro F., Cravo M., Kalluri R., MacHado J.C., Melo S.A.,
Gaiteiro C., Soares J., Relvas-Santos M., Peixoto A., Ferreira D., Paulo P., Brandão A., Fernandes E., Azevedo R., Palmeira C., Freitas R., Miranda A., Osório H., Prieto J., Lima L., Silva A.M.N., Santos L.L., Ferreira J.A.,
Gomes C., Almeida A., Barreira A., Calheiros J., Pinto F., Abrantes R., Costa A., Polonia A., Campos D., Osório H., Sousa H., Pinto-De-Sousa J., Kolarich D., Reis C.A.,
Freitas D., Balmaña M., Poças J., Campos D., Osório H., Konstantinidi A., Vakhrushev S.Y., Magalhães A., Reis C.A.,
Osório H., Reis C.A.,
Gomes C., Almeida A., Ferreira J.A., Silva L., Santos-Sousa H., Pinto-De-Sousa J., Santos L.L., Amado F., Schwientek T., Levery S.B., Mandel U., Clausen H., David L., Reis C.A., Osório H.,
Proteomics analysis of gastric cancer patients with diabetes mellitus. Journal of Clinical Medicine10(3):1-14, 2021. [Journal: Article] [CI: 28] [IF: 5]
DOI: 10.3390/jcm10030407 SCOPUS: 85108977672.
DOI: 10.3390/jcm10030407 SCOPUS: 85108977672.
Poças J., Marques C., Gomes C., Otake A.H., Pinto F., Ferreira M., Silva T., Faria-Ramos I., Matos R., Ribeiro A.R., Senra E., Cavadas B., Batista S., Maia J., Macedo J.A., Lima L., Afonso L.P., Ferreira J.A., Santos L.L., Polónia A., Osório H., Belting M., Reis C.A., Costa-Silva B., Magalhães A.,
Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival. Proceedings of the National Academy of Sciences of the United States of America120(20):, 2023. [Journal: Article] [CI: 4] [IF: 11,1 (*)]
DOI: 10.1073/pnas.2214853120 SCOPUS: 85158135443.
DOI: 10.1073/pnas.2214853120 SCOPUS: 85158135443.
Martins Á.M., Lopes T.M., Diniz F., Pires J., Osório H., Pinto F., Freitas D., Reis C.A.,
Differential Protein and Glycan Packaging into Extracellular Vesicles in Response to 3D Gastric Cancer Cellular Organization. Advanced Science:, 2023. [Journal: Article] [CI: 1] [IF: 15,1 (*)]
DOI: 10.1002/advs.202300588 SCOPUS: 85162202761.
DOI: 10.1002/advs.202300588 SCOPUS: 85162202761.
Zhang H., Freitas D., Kim H.S., Fabijanic K., Li Z., Chen H., Mark M.T., Molina H., Martin A.B., Bojmar L., Fang J., Rampersaud S., Hoshino A., Matei I., Kenific C.M., Nakajima M., Mutvei A.P., Sansone P., Buehring W., Wang H., Jimenez J.P., Cohen-Gould L., Paknejad N., Brendel M., Manova-Todorova K., Magalhães A., Ferreira J.A., Osório H., Silva A.M., Massey A., Cubillos-Ruiz J.R., Galletti G., Giannakakou P., Cuervo A.M., Blenis J., Schwartz R., Brady M.S., Peinado H., Bromberg J., Matsui H., Reis C.A., Lyden D.,
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nature Cell Biology20(3):332-343, 2018. [Journal: Article] [CI: 1010] [IF: 17,7]
DOI: 10.1038/s41556-018-0040-4 SCOPUS: 85042193942.
DOI: 10.1038/s41556-018-0040-4 SCOPUS: 85042193942.
Ruivo C.F., Bastos N., Adem B., Batista I., Duraes C., Melo C.A., Castaldo S.A., Campos-Labori F., Moutinho-Ribeir P., Morão B., Costa-Pint A., Silva S., Osorio H., Ciordia S., Costa J.L., Goodrich D., Cavadas B., Pereira L., Kouzarides T., MacEdo G., Maio R., Carneiro F., Cravo M., Kalluri R., MacHado J.C., Melo S.A.,
Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression. Gut71(10):2043-2068, 2022. [Journal: Article] [CI: 43] [IF: 24,5]
DOI: 10.1136/gutjnl-2021-324994 SCOPUS: 85130807227.
DOI: 10.1136/gutjnl-2021-324994 SCOPUS: 85130807227.
Gaiteiro C., Soares J., Relvas-Santos M., Peixoto A., Ferreira D., Paulo P., Brandão A., Fernandes E., Azevedo R., Palmeira C., Freitas R., Miranda A., Osório H., Prieto J., Lima L., Silva A.M.N., Santos L.L., Ferreira J.A.,
Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion. Theranostics12(7):3150-3177, 2022. [Journal: Article] [CI: 9] [IF: 12,4]
DOI: 10.7150/thno.67409 SCOPUS: 85128304436.
DOI: 10.7150/thno.67409 SCOPUS: 85128304436.
Gomes C., Almeida A., Barreira A., Calheiros J., Pinto F., Abrantes R., Costa A., Polonia A., Campos D., Osório H., Sousa H., Pinto-De-Sousa J., Kolarich D., Reis C.A.,
Carcinoembryonic antigen carrying SLeX as a new biomarker of more aggressive gastric carcinomas. Theranostics9(24):7431-7446, 2020. [Journal: Article] [CI: 31] [IF: 11,6]
DOI: 10.7150/thno.33858 SCOPUS: 85074719039.
DOI: 10.7150/thno.33858 SCOPUS: 85074719039.
Freitas D., Balmaña M., Poças J., Campos D., Osório H., Konstantinidi A., Vakhrushev S.Y., Magalhães A., Reis C.A.,
Different isolation approaches lead to diverse glycosylated extracellular vesicle populations. Journal of Extracellular Vesicles8(1):, 2019. [Journal: Article] [CI: 71] [IF: 15]
DOI: 10.1080/20013078.2019.1621131 SCOPUS: 85074725417.
DOI: 10.1080/20013078.2019.1621131 SCOPUS: 85074725417.
Osório H., Reis C.A.,
Mass spectrometry methods for studying glycosylation in cancer. Methods in Molecular Biology1007:301-316, 2013. [Book Series: Article] [CI: 18]
DOI: 10.1007/978-1-62703-392-3_13 SCOPUS: 84883156078.
DOI: 10.1007/978-1-62703-392-3_13 SCOPUS: 84883156078.
Gomes C., Almeida A., Ferreira J.A., Silva L., Santos-Sousa H., Pinto-De-Sousa J., Santos L.L., Amado F., Schwientek T., Levery S.B., Mandel U., Clausen H., David L., Reis C.A., Osório H.,
Glycoproteomic analysis of serum from patients with gastric precancerous lesions. Journal of Proteome Research12(3):1454-1466, 2013. [Journal: Article] [CI: 66] [IF: 5]
DOI: 10.1021/pr301112x SCOPUS: 84874635340.
DOI: 10.1021/pr301112x SCOPUS: 84874635340.