Where Ideas Grow
Hugo Osório
Platform Head

Hugo Osorio graduated in Biochemistry (1999) and holds a PhD in Biomedical Sciences (2004) from the University of Porto. His research focuses on the development and application of mass-spectrometry based proteomics approaches in biomedicine with a focus on cancer proteomics and glycosylation profiling. Hugo Osorio is the Head of the i3S Proteomics Scientific Platform and Professor at University of Porto. He is member of the board of the Portuguese Proteomics Association – ProCura and manages the i3S node of the Portuguese Mass Spectrometry Network- RNEM integrated in the FCT Research Infrastructures RoadMap. He organizes and participates in pre and postgraduate mass spectrometry and proteomics courses. As of November 2021, Hugo Osorio has 75 publications in international peer-reviewed journals and three book chapters. His research work has over 2000 citations and with an h-index of 20 (Scopus).

Selected Publications

Osório H., Silva C., Ferreira M., Gullo I., Máximo V., Barros R., Mendonça F., Oliveira C., Carneiro F.,
Proteomics analysis of gastric cancer patients with diabetes mellitus. Journal of Clinical Medicine10(3):1-14, 2021. [Journal: Article] [CI: 2] [IF: 4.2 (*)]
DOI: 10.3390/jcm10030407 SCOPUS: 85108977672.


Zhang H., Freitas D., Kim H.S., Fabijanic K., Li Z., Chen H., Mark M.T., Molina H., Martin A.B., Bojmar L., Fang J., Rampersaud S., Hoshino A., Matei I., Kenific C.M., Nakajima M., Mutvei A.P., Sansone P., Buehring W., Wang H., Jimenez J.P., Cohen-Gould L., Paknejad N., Brendel M., Manova-Todorova K., Magalhães A., Ferreira J.A., Osório H., Silva A.M., Massey A., Cubillos-Ruiz J.R., Galletti G., Giannakakou P., Cuervo A.M., Blenis J., Schwartz R., Brady M.S., Peinado H., Bromberg J., Matsui H., Reis C.A., Lyden D.,
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nature Cell Biology20(3):332-343, 2018. [Journal: Article] [CI: 507] [IF: 17,7]
DOI: 10.1038/s41556-018-0040-4 SCOPUS: 85042193942.


Gomes C., Almeida A., Barreira A., Calheiros J., Pinto F., Abrantes R., Costa A., Polonia A., Campos D., Osório H., Sousa H., Pinto-De-Sousa J., Kolarich D., Reis C.A.,
Carcinoembryonic antigen carrying SLeX as a new biomarker of more aggressive gastric carcinomas. Theranostics9(24):7431-7446, 2020. [Journal: Article] [CI: 13] [IF: 11.6]
DOI: 10.7150/thno.33858 SCOPUS: 85074719039.


Marques M.S., Costa A.C., Osório H., Pinto M.L., Relvas S., Dinis-Ribeiro M., Carneiro F., Leite M., Figueiredo C.,
Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity. Gut Microbes13(1):1-21, 2021. [Journal: Article] [IF: 10.2 (*)]
DOI: 10.1080/19490976.2021.1921928 SCOPUS: 85105768485.


Freitas D., Balmaña M., Poças J., Campos D., Osório H., Konstantinidi A., Vakhrushev S.Y., Magalhães A., Reis C.A.,
Different isolation approaches lead to diverse glycosylated extracellular vesicle populations. Journal of Extracellular Vesicles8(1):, 2019. [Journal: Article] [CI: 35] [IF: 15]
DOI: 10.1080/20013078.2019.1621131 SCOPUS: 85074725417.


Korsak B., Almeida G.M., Rocha S., Pereira C., Mendes N., Osório H., Pereira P.M.R., Rodrigues J.M.M., Schneider R.J., Sarmento B., Tomé J.P.C., Oliveira C.,
Porphyrin modified trastuzumab improves efficacy of HER2 targeted photodynamic therapy of gastric cancer. International Journal of Cancer141(7):1478-1489, 2017. [Journal: Article] [CI: 13] [IF: 7,4]
DOI: 10.1002/ijc.30844 SCOPUS: 85022335625.


Duarte H.O., Balmaña M., Mereiter S., Osório H., Gomes J., Reis C.A.,
Gastric cancer cell glycosylation as a modulator of the ErbB2 oncogenic receptor. International Journal of Molecular Sciences18(11):, 2017. [Journal: Article] [CI: 18] [IF: 3,7]
DOI: 10.3390/ijms18112262 SCOPUS: 85032689258.


Melo J., Pinto V., Fernandes T., Malheiro A.R., Osório H., Figueiredo C., Leite M.,
Isolation Method and Characterization of Outer Membranes Vesicles of Helicobacter pylori Grown in a Chemically Defined Medium. Frontiers in Microbiology12:, 2021. [Journal: Article] [IF: 5.6 (*)]
DOI: 10.3389/fmicb.2021.654193 SCOPUS: 85108164338.


Osório H., Reis C.A.,
Mass spectrometry methods for studying glycosylation in cancer. Methods in Molecular Biology1007:301-316, 2013. [Book Series: Article] [CI: 18]
DOI: 10.1007/978-1-62703-392-3_13 SCOPUS: 84883156078.


Gomes C., Almeida A., Ferreira J.A., Silva L., Santos-Sousa H., Pinto-De-Sousa J., Santos L.L., Amado F., Schwientek T., Levery S.B., Mandel U., Clausen H., David L., Reis C.A., Osório H.,
Glycoproteomic analysis of serum from patients with gastric precancerous lesions. Journal of Proteome Research12(3):1454-1466, 2013. [Journal: Article] [CI: 50] [IF: 5]
DOI: 10.1021/pr301112x SCOPUS: 84874635340.


Catera M., Borelli V., Malagolini N., Chiricolo M., Venturi G., Reis C., Osorio H., Abruzzo P.M., Capri M., Monti D., Ostan R., Franceschi C., Dall'Olio F.,
Identification of novel plasma glycosylation-associated markers of aging. Oncotarget7(7):7455-7468, 2016. [Journal: Article] [CI: 19] [IF: 5,2]
DOI: 10.18632/oncotarget.7059 SCOPUS: 84958817824.


Reis C.A., Osorio H., Silva L., Gomes C., David L.,
Alterations in glycosylation as biomarkers for cancer detection. Journal of Clinical Pathology63(4):322-329, 2010. [Journal: Review] [CI: 311] [IF: 2,5]
DOI: 10.1136/jcp.2009.071035 SCOPUS: 77950410995.