Inês graduated in Biochemistry in 2012 by University of Aveiro and completed the MSc in Biochemistry at the same institution in the end of 2014. During the MSc dissertation work, Inês studied the contribution of ER stress to tumor immunosuppressive microenvironment. During her academic career, she has also participated actively in other projects; In 2009 Inês was accepted for a research fellowship (BII, FCT) for the project NMR Studies of material with biological and pharmacological interest (CICECO, University of Aveiro); she also integrate an internship in Laboratory of biochemistry analysis in Hospital Português, Salvador, Brasil; and at the end of BSc graduation she entered in Erasmus program in Università degli studi di Pavia, Italy.
In January of 2015, she was granted with an Albert Renold Travel Fellowship by European Association for the Study of Diabetes to develop work on age-associated metabolic processes underlying type II diabetes with Dr. Eugenia Carvalho’s group (CNC, Coimbra, Portugal) at the University of Arkansas for Medical Sciences; with this visit she acquired some expertise in stable isotope mass spectrometry and also ex vivo tissue respirometry (OROBOROS).
In 2016 Ines joined National Institute of Health (Doutor Ricardo Jorge, Lisboa) with a FCT Research fellowship (BIM), in Genomic diseases’ Lab, Lisbon.
Presently, Inês is studying the impact of N-glycosylation modifications in autoimmune diseases and its potential targets for therapeutics, under the supervision of Salomé Pinho at the Glycobiology in cancer group (IPATIMUP/I3S, Porto).
Currently she is a PhD Student under the supervision of Dra. Salomé Pinho (FMUP, i3S/IPATIMUP), Dr. António Marinho (Unidade de Imunologia Clínica do Centro Hospitalar do Porto) e Dr. Gabriel Rabinovich (Instituto de Biologia y Medicina Experimental, Buenos Aires) at the Immunology, Cancer and Glycomedicine Group at i3S.
Publicações Selecionadas
Protein Mannosylation as a Diagnostic and Prognostic Biomarker of Lupus Nephritis: An Unusual Glycan Neoepitope in Systemic Lupus Erythematosus. Arthritis and Rheumatology73(11):2069-2077, 2021. [Journal: Article] [CI: 22] [IF: 15,5]
DOI: 10.1002/art.41768 SCOPUS: 85114632866
Alves I., Vicente M.M., Gaifem J., Fernandes Â., Dias A.M., Rodrigues C.S., Oliveira J.C., Seixas N., Malheiro L., Abreu M.A., Castro R.S., Pinho S.S.
SARS-CoV-2 Infection drives a glycan switch of peripheral T cells at diagnosis. Journal of Immunology207(6):1591-1598, 2021. [Journal: Article] [CI: 7] [IF: 5,4]
DOI: 10.4049/jimmunol.2100131 SCOPUS: 85114625464
Alves I., Fernandes Â., Santos-Pereira B., Azevedo C.M., Pinho S.S.
Glycans as a key factor in self and nonself discrimination: impact on the breach of immune tolerance. FEBS Letters596(12):1485-1502, 2022. [Journal: Review] [CI: 31] [IF: 3,5]
DOI: 10.1002/1873-3468.14347 SCOPUS: 85128204331
Pereira M.S., Alves I., Vicente M., Campar A., Silva M.C., Padrão N.A., Pinto V., Fernandes Å., Dias A.M., Pinho S.S.
Glycans as key checkpoints of T cell activity and function. Frontiers in Immunology9(NOV):, 2018. [Journal: Review] [CI: 121] [IF: 4,7]
DOI: 10.3389/fimmu.2018.02754 SCOPUS: 85057432575
Alves I., Vicente M.M., Dias A.M., Gaifem J., Rodrigues C., Campar A., Pinho S.S.
The Role of Glycosylation in Inflammatory Diseases. Advances in Experimental Medicine and Biology1325:265-283, 2021. [Book Series: Book Chapter] [CI: 7] [IF: 3,7]
DOI: 10.1007/978-3-030-70115-4_13 SCOPUS: 85115034497
Mortha A., Remark R., Del Valle D.M., Chuang L.S., Chai Z., Alves I., Azevedo C., Gaifem J., Martin J., Petralia F., Tuballes K., Barcessat V., Tai S.L., Huang H.H., Laface I., Jerez Y.A., Boschetti G., Villaverde N., Wang M.D., Korie U.M., Murray J., Choung R.S., Sato T., Laird R.M., Plevy S., Rahman A., Torres J., Porter C., Riddle M.S., Kenigsberg E., Pinho S.S., Cho J.H., Merad M., Colombel J.F., Gnjatic S.
Neutralizing Anti-Granulocyte Macrophage-Colony Stimulating Factor Autoantibodies Recognize Post-Translational Glycosylations on Granulocyte Macrophage-Colony Stimulating Factor Years Before Diagnosis and Predict Complicated Crohn's Disease. Gastroenterology163(3):659-670, 2022. [Journal: Article] [CI: 42] [IF: 29,4]
DOI: 10.1053/j.gastro.2022.05.029 SCOPUS: 85134834619
Dias A.M., Correia A., Pereira M.S., Almeida C.R., Alves I., Pinto V., Catarino T.A., Mendes N., Leander M., Teresa Oliva-Teles M., Maia L., Delerue-Matos C., Taniguchi N., Lima M., Pedroto I., Marcos-Pinto R., Lago P., Reis C.A., Vilanova M., Pinho S.S.
Metabolic control of T cell immune response through glycans in inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America115(20):E4651-E4660, 2018. [Journal: Article] [CI: 91] [IF: 9,6]
DOI: 10.1073/pnas.1720409115 SCOPUS: 85046964805
Dias A.M., Pereira M.S., Padrão N.A., Alves I., Marcos-Pinto R., Lago P., Pinho S.S.
Glycans as critical regulators of gut immunity in homeostasis and disease. Cellular Immunology333:9-18, 2018. [Journal: Article] [CI: 28] [IF: 3,3]
DOI: 10.1016/j.cellimm.2018.07.007 SCOPUS: 85050201106
Petrović T., Alves I., Bugada D., Pascual J., Vučković F., Skelin A., Gaifem J., Villar-Garcia J., Vicente M.M., Fernandes A., Dias A.M., Kurolt I.C., Markotić A., Primorac D., Soares A., Malheiro L., Trbojević-Akmačić I., Abreu M., Castro R.S.E., Bettinelli S., Callegaro A., Arosio M., Sangiorgio L., Lorini L.F., Castells X., Horcajada J.P., Pinho S.S., Allegri M., Barrios C., Lauc G.
Composition of the immunoglobulin G glycome associates with the severity of COVID-19. Glycobiology31(4):372-377, 2021. [Journal: Article] [CI: 32] [IF: 6]
DOI: 10.1093/glycob/cwaa102 SCOPUS: 85105131558
Vicente M.M., Alves I., Gaifem J., Rodrigues C.S., Fernandes Â., Dias A.M., Štambuk J., Petrović T., Oliveira P., Ferreira-da-Silva F., Soares A., Seixas N., Teixeira T., Malheiro L., Lauc G., Sarmento e Castro R., Pinho S.S.
Altered IgG glycosylation at COVID-19 diagnosis predicts disease severity. European Journal of Immunology52(6):946-957, 2022. [Journal: Article] [CI: 29] [IF: 5,4]
DOI: 10.1002/eji.202149491 SCOPUS: 85127438421