Where Ideas Grow
Ana Ribeiro
Junior Researcher
Ana Sofia Ribeiro studied Biochemistry at Science Faculty of Oporto University and performed her training period in the Immunology and cell biology group from Wageningen University, in the Netherlands, under the supervision of Jan Rombout and Heidi Huttenhuis. Her graduate studies were followed by a master degree in oncobiology at Medical faculty of Oporto University and Ipatimup, with the thesis untitled ""P-cadherin: role in breast cancer cell migration and invasion"", under supervision of Fernando Schmitt. In 2008, she initiated her phD work at Ipatimup, supervised by Fernando Schmitt and Joana Paredes, where she investigated the role of two cell adhesion molecules, E- and P-cadherin, in breast cancer progression. Ana Sofia Ribeiro is currently a pos-doctoral researcher in Joana Paredes group. Ana?s research focuses on the molecular and signalling mechanism, involved in cancer cell invasion and metastization, more specifically on the role of cell-cell adhesion molecules (E- and P-cadherin) and ECM crosstalk in Breast cancer. Her work has reinforced the importance of P-cadherin expression as a prognostic factor for breast cancer patients, supporting the development of new therapeutics to control aggressive carcinomas that express this epithelial cadherin. Ana Sofia Ribeiro work originated 2 Thesis on P-cadherin role in breast cancer progression, 23 publications in international peer-review journals, with a total number of 270 citations and a total cumulative IF of 116.43. She is the first author of 4 manuscripts (Q1 journals) and is highly involved in the group publications on P-cadherin and cancer research and has a h-index of 13. Her results were published in top cancer-related journals, including Oncogene, Cancer Research, Breast Cancer Research and BBA Reviews on Cancer.

Selected Publications

Ribeiro A.S., Carvalho F.A., Figueiredo J., Carvalho R., Mestre T., Monteiro J., Guedes A.F., Fonseca M., Sanches J., Seruca R., Santos N.C., Paredes J.,
Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells. Nanoscale8(46):19390-19401, 2016. [Journal: Article] [CI: 13] [IF: 7,4]
DOI: 10.1039/c6nr04465d SCOPUS: 84998881935.

Ribeiro A.S., Paredes J.,
P-cadherin linking breast cancer stem cells and invasion: A promising marker to identify an "intermediate/metastable" EMT state. Frontiers in Oncology4:, 2015. [Journal: Article] [CI: 74]
DOI: 10.3389/fonc.2014.00371 SCOPUS: 85018189090.

Ribeiro A.S., Sousa B., Carreto L., Mendes N., Nobre A.R., Ricardo S., Albergaria A., Cameselle-Teijeiro J.F., Gerhard R., Söderberg O., Seruca R., Santos M.A., Schmitt F., Paredes J.,
P-cadherin functional role is dependent on E-cadherin cellular context: A proof of concept using the breast cancer model. Journal of Pathology229(5):705-718, 2013. [Journal: Article] [CI: 61] [IF: 7,3]
DOI: 10.1002/path.4143 SCOPUS: 84875054847.

Ribeiro A.S., Albergaria A., Sousa B., Correia A.L., Bracke M., Seruca R., Schmitt F.C., Paredes J.,
Extracellular cleavage and shedding of P-cadherin: A mechanism underlying the invasive behaviour of breast cancer cells. Oncogene29(3):392-402, 2010. [Journal: Article] [CI: 89] [IF: 7,4]
DOI: 10.1038/onc.2009.338 SCOPUS: 75149183984.

Paredes J., Figueiredo J., Albergaria A., Oliveira P., Carvalho J., Ribeiro A.S., Caldeira J., Costa A.M., Simões-Correia J., Oliveira M.J., Pinheiro H., Pinho S.S., Mateus R., Reis C.A., Leite M., Fernandes M.S., Schmitt F., Carneiro F., Figueiredo C., Oliveira C., Seruca R.,
Epithelial E- and P-cadherins: Role and clinical significance in cancer. Biochimica et Biophysica Acta - Reviews on Cancer1826(2):297-311, 2012. [Journal: Review] [CI: 166] [IF: 9]
DOI: 10.1016/j.bbcan.2012.05.002 SCOPUS: 84861800037.