creating a
healthier future
Raquel Almeida
Group leader
Raquel Almeida is a researcher, leader of the group ?Differentiation and cancer? and Invited Assistant Professor at the Faculty of Sciences, University of Porto. After a first degree in Biology, she did a PhD in Copenhagen University and a post-doc in IPATIMUP. Major contributions of her work have been the: 1. identification and characterization of glycosyltransferase gene families and their involvement in disease, 2. identification of CDX2 as a key player in the transdifferentiation of the gastric mucosa to an intestinal phenotype that predisposes to cancer. Current research interests are to study the involvement of differentiation abnormalities in cancer initiation and progression. She has published over 45 papers in peer-reviewed journals, has an H-index=21 and supervised the work of 4 PhD students.

Selected Publications

Pereira B., Billaud M., Almeida R.,
RNA-Binding Proteins in Cancer: Old Players and New Actors. Trends in Cancer3(7):506-528, 2017. [Journal: Review] [CI: 454] [IF: 7]
DOI: 10.1016/j.trecan.2017.05.003 SCOPUS: 85020932454.

Camilo V., Garrido M., Valente P., Ricardo S., Amaral A.L., Barros R., Chaves P., Carneiro F., David L., Almeida R.,
Differentiation reprogramming in gastric intestinal metaplasia and dysplasia: Role of SOX2 and CDX2. Histopathology66(3):343-350, 2015. [Journal: Article] [CI: 32] [IF: 3,4]
DOI: 10.1111/his.12544 SCOPUS: 84921489545.

Camilo V., Barros R., Celestino R., Castro P., Vieira J., Teixeira M.R., Carneiro F., Pinto-de-Sousa J., David L., Almeida R.,
Immunohistochemical molecular phenotypes of gastric cancer based on SOX2 and CDX2 predict patient outcome. BMC Cancer14(1):, 2014. [Journal: Article] [CI: 33] [IF: 3,4]
DOI: 10.1186/1471-2407-14-753 SCOPUS: 84935505045.

Pereira B., Sousa S., Barros R., Carreto L., Oliveira P., Oliveira C., Chartier N.T., Plateroti M., Rouault J.P., Freund J.N., Billaud M., Almeida R.,
CDX2 regulation by the RNA-binding protein MEX3A: Impact on intestinal differentiation and stemness. Nucleic Acids Research41(7):3986-3999, 2013. [Journal: Article] [CI: 68] [IF: 8,8]
DOI: 10.1093/nar/gkt087 SCOPUS: 84876542486.

Barros R., Freund J.N., David L., Almeida R.,
Gastric intestinal metaplasia revisited: Function and regulation of CDX2. Trends in Molecular Medicine18(9):555-563, 2012. [Journal: Review] [CI: 58] [IF: 9,6]
DOI: 10.1016/j.molmed.2012.07.006 SCOPUS: 84865606611.

Camilo V., Barros R., Sousa S., Magalhães A.M., Lopes T., Santos A.M., Pereira T., Figueiredo C., David L., Almeida R.,
Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells. Carcinogenesis33(10):1985-1992, 2012. [Journal: Article] [CI: 56] [IF: 5,6]
DOI: 10.1093/carcin/bgs233 SCOPUS: 84865579254.

Barros R., Da Costa L.T., Pinto-de-Sousa J., Duluc I., Freund J.N., David L., Almeida R.,
CDX2 autoregulation in human intestinal metaplasia of the stomach: Impact on the stability of the phenotype. Gut60(3):290-298, 2011. [Journal: Article] [CI: 50] [IF: 10,1]
DOI: 10.1136/gut.2010.222323 SCOPUS: 79851514659.

Barros R., Pereira B., Duluc I., Azevedo M., Mendes N., Camilo V., Jacobs R.J., Paulo P., Santos-Silva F., Van Seuningen I., Van Den Brink G.R., David L., Freund J.N., Almeida R.,
Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. Journal of Pathology215(4):411-420, 2008. [Journal: Article] [CI: 58] [IF: 5,1]
DOI: 10.1002/path.2369 SCOPUS: 49449092484.

Pinto R., Hansen L., Hintze J., Almeida R., Larsen S., Coskun M., Davidsen J., Mitchelmore C., David L., Troelsen J.T., Bennett E.P.,
Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression. Nucleic Acids Research45(13):, 2017. [Journal: Article] [CI: 16] [IF: 11,6]
DOI: 10.1093/nar/gkx371 SCOPUS: 85026430499.

Bruun J., Sveen A., Barros R., Eide P.W., Eilertsen I., Kolberg M., Pellinen T., David L., Svindland A., Kallioniemi O., Guren M.G., Nesbakken A., Almeida R., Lothe R.A.,
Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer. Molecular Oncology12(9):1639-1655, 2018. [Journal: Article] [CI: 35] [IF: 6]
DOI: 10.1002/1878-0261.12347 SCOPUS: 85052656489.