Alexandra Moreira
Gene Regulation
Group leader
Alexandra Moreira holds a D. Phil. in Molecular Biology, University of Oxford, UK and a degree in Biochemistry, Faculty of Sciences, University of Lisbon. She currently holds a Principal Investigator position at the University of Porto and is the leader of the group Gene Regulation. Together with her research activities, A. Moreira lectures at ICBAS, teaches at several MSc and PhD courses and is a member of the Scientific Board of the Molecular and Cell Biology PhD Program, University Porto. A. Moreira has served as a member of the IBMC Executive Committee in the past. The objective of her research group is to understand the molecular mechanisms involved in the integration of RNAPII transcription and alternative pre-mRNA processing, with a focus on those events that are physiologically relevant in health and disease, using state-of-the-art molecular biology methodologies.
Selected Publications
Pereira-Castro I., Moreira A.,
Wilton J., Tellier M., Nojima T., Costa A.M., Oliveira M.J., Moreira A.,
Oliveira M.S., Freitas J., Pinto P.A.B., De Jesus A., Tavares J., Pinho M., Domingues R.G., Henriques T., Lopes C., Conde C., Sunkel C.E., Moreira A.,
Liu X., Freitas J., Zheng D., Oliveira M.S., Hoque M., Martins T., Henriques T., Tian B., Moreira A.,
Rodrigues P.M., Ribeiro A.R., Perrod C., Landry J.J.M., Araújo L., Pereira-Castro I., Benes V., Moreira A., Xavier-Ferreira H., Meireles C., Alves N.L.,
Braz S.O., Cruz A., Lobo A., Bravo J., Moreira-Ribeiro J., Pereira-Castro I., Freitas J., Relvas J.B., Summavielle T., Moreira A.,
Domingues R.G., Lago-Baldaia I., Pereira-Castro I., Fachini J.M., Oliveira L., Drpic D., Lopes N., Henriques T., Neilson J.R., Carmo A.M., Moreira A.,
Da Glória V.G., De Araújo M.M., Santos A.M., Leal R., De Almeida S.F., Carmo A.M., Moreira A.,
Curinha A., Braz S.O., Pereira-Castro I., Cruz A., Moreira A.,
Pinto P.A.B., Henriques T., Freitas M.O., Martins T., Domingues R.G., Wyrzykowska P.S., Coelho P.A., Carmo A.M., Sunkel C.E., Proudfoot N.J., Moreira A.,
On the function and relevance of alternative 3'-UTRs in gene expression regulation. Wiley Interdisciplinary Reviews: RNA12(5):, 2021. [Journal: Review] [CI: 28] [IF: 9,3]
DOI: 10.1002/wrna.1653 SCOPUS: 85104155614.
DOI: 10.1002/wrna.1653 SCOPUS: 85104155614.
Wilton J., Tellier M., Nojima T., Costa A.M., Oliveira M.J., Moreira A.,
Simultaneous studies of gene expression and alternative polyadenylation in primary human immune cells. Methods in Enzymology655:349-399, 2021. [Book Series: Book Chapter] [CI: 2] [IF: 1,7]
DOI: 10.1016/bs.mie.2021.04.004 SCOPUS: 85108098928.
DOI: 10.1016/bs.mie.2021.04.004 SCOPUS: 85108098928.
Oliveira M.S., Freitas J., Pinto P.A.B., De Jesus A., Tavares J., Pinho M., Domingues R.G., Henriques T., Lopes C., Conde C., Sunkel C.E., Moreira A.,
Cell cycle kinase polo is controlled by a widespread 3=untranslated region regulatory sequence in Drosophila melanogaster. Molecular and Cellular Biology39(15):, 2019. [Journal: Article] [CI: 4] [IF: 3,6]
DOI: 10.1128/MCB.00581-18 SCOPUS: 85070024885.
DOI: 10.1128/MCB.00581-18 SCOPUS: 85070024885.
Liu X., Freitas J., Zheng D., Oliveira M.S., Hoque M., Martins T., Henriques T., Tian B., Moreira A.,
Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster. RNA23(12):1807-1816, 2017. [Journal: Article] [CI: 39] [IF: 4,5]
DOI: 10.1261/rna.062661.117 SCOPUS: 85034084061.
DOI: 10.1261/rna.062661.117 SCOPUS: 85034084061.
Rodrigues P.M., Ribeiro A.R., Perrod C., Landry J.J.M., Araújo L., Pereira-Castro I., Benes V., Moreira A., Xavier-Ferreira H., Meireles C., Alves N.L.,
Thymic epithelial cells require p53 to support their long-term function in thymopoiesis in mice. Blood130(4):478-488, 2017. [Journal: Article] [CI: 27] [IF: 15,1]
DOI: 10.1182/blood-2016-12-758961 SCOPUS: 85026293874.
DOI: 10.1182/blood-2016-12-758961 SCOPUS: 85026293874.
Braz S.O., Cruz A., Lobo A., Bravo J., Moreira-Ribeiro J., Pereira-Castro I., Freitas J., Relvas J.B., Summavielle T., Moreira A.,
Expression of Rac1 alternative 3' UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms1860(6):685-694, 2017. [Journal: Article] [CI: 9] [IF: 5,2]
DOI: 10.1016/j.bbagrm.2017.03.002 SCOPUS: 85018940086.
DOI: 10.1016/j.bbagrm.2017.03.002 SCOPUS: 85018940086.
Domingues R.G., Lago-Baldaia I., Pereira-Castro I., Fachini J.M., Oliveira L., Drpic D., Lopes N., Henriques T., Neilson J.R., Carmo A.M., Moreira A.,
CD5 expression is regulated during human T-cell activation by alternative polyadenylation, PTBP1, and miR-204. European Journal of Immunology46(6):1490-1503, 2016. [Journal: Article] [CI: 28] [IF: 4,2]
DOI: 10.1002/eji.201545663 SCOPUS: 84973661630.
DOI: 10.1002/eji.201545663 SCOPUS: 84973661630.
Da Glória V.G., De Araújo M.M., Santos A.M., Leal R., De Almeida S.F., Carmo A.M., Moreira A.,
T cell activation regulates CD6 alternative splicing by transcription dynamics and SRSF1. Journal of Immunology193(1):391-399, 2014. [Journal: Article] [CI: 24] [IF: 4,9]
DOI: 10.4049/jimmunol.1400038 SCOPUS: 84903626125.
DOI: 10.4049/jimmunol.1400038 SCOPUS: 84903626125.
Curinha A., Braz S.O., Pereira-Castro I., Cruz A., Moreira A.,
Implications of polyadenylation in health and disease. Nucleus5(6):508-519, 2014. [Journal: Article] [CI: 104] [IF: 3]
DOI: 10.4161/nucl.36360 SCOPUS: 84921902866.
DOI: 10.4161/nucl.36360 SCOPUS: 84921902866.
Pinto P.A.B., Henriques T., Freitas M.O., Martins T., Domingues R.G., Wyrzykowska P.S., Coelho P.A., Carmo A.M., Sunkel C.E., Proudfoot N.J., Moreira A.,
RNA polymerase II kinetics in polo polyadenylation signal selection. EMBO Journal30(12):2431-2444, 2011. [Journal: Article] [CI: 102] [IF: 9,2]
DOI: 10.1038/emboj.2011.156 SCOPUS: 79958859723.
DOI: 10.1038/emboj.2011.156 SCOPUS: 79958859723.