Isabel Castro
Gene Regulation
Junior Researcher
Isabel Pereira-Castro holds a degree in Biology, a master in Molecular Oncology and a PhD in Biomedicine by the University of Porto. During her Master and PhD studies she developed her research in IPATIMUP where she studied the function of a novel Wnt pathway member in vertebrate tumourigenesis and the evolution and regulation of two overlapping genes. Currently she is a Junior Researcher in the Gene Regulation group, where she is dissecting the molecular mechanisms controlling alternative polyadenylation in human T cells.
Selected Publications
Pereira-Castro I., Garcia B.C., Curinha A., Neves-Costa A., Conde-Sousa E., Moita L.F., Moreira A.,
Pereira-Castro I., Moreira A.,
Braz S.O., Cruz A., Lobo A., Bravo J., Moreira-Ribeiro J., Pereira-Castro I., Freitas J., Relvas J.B., Summavielle T., Moreira A.,
Rodrigues P.M., Ribeiro A.R., Perrod C., Landry J.J.M., Araújo L., Pereira-Castro I., Benes V., Moreira A., Xavier-Ferreira H., Meireles C., Alves N.L.,
Domingues R.G., Lago-Baldaia I., Pereira-Castro I., Fachini J.M., Oliveira L., Drpic D., Lopes N., Henriques T., Neilson J.R., Carmo A.M., Moreira A.,
Duarte-Pereira S., Pereira-Castro I., Silva S.S., Correia M.G., Neto C., da Costa L.T., Amorim A., Silva R.M.,
Pereira F., Duarte-Pereira S., Silva R.M., Da Costa L.T., Pereira-Castro I.,
Curinha A., Braz S.O., Pereira-Castro I., Cruz A., Moreira A.,
Pereira-Castro I., Quental R., Da Costa L.T., Amorim A., Azevedo L.,
MCL1 alternative polyadenylation is essential for cell survival and mitochondria morphology. Cellular and Molecular Life Sciences79(3):, 2022. [Journal: Article] [CI: 6] [IF: 8]
DOI: 10.1007/s00018-022-04172-x SCOPUS: 85125559845.
DOI: 10.1007/s00018-022-04172-x SCOPUS: 85125559845.
Pereira-Castro I., Moreira A.,
On the function and relevance of alternative 3'-UTRs in gene expression regulation. Wiley Interdisciplinary Reviews: RNA12(5):, 2021. [Journal: Review] [CI: 28] [IF: 9,3]
DOI: 10.1002/wrna.1653 SCOPUS: 85104155614.
DOI: 10.1002/wrna.1653 SCOPUS: 85104155614.
Braz S.O., Cruz A., Lobo A., Bravo J., Moreira-Ribeiro J., Pereira-Castro I., Freitas J., Relvas J.B., Summavielle T., Moreira A.,
Expression of Rac1 alternative 3' UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms1860(6):685-694, 2017. [Journal: Article] [CI: 9] [IF: 5,2]
DOI: 10.1016/j.bbagrm.2017.03.002 SCOPUS: 85018940086.
DOI: 10.1016/j.bbagrm.2017.03.002 SCOPUS: 85018940086.
Rodrigues P.M., Ribeiro A.R., Perrod C., Landry J.J.M., Araújo L., Pereira-Castro I., Benes V., Moreira A., Xavier-Ferreira H., Meireles C., Alves N.L.,
Thymic epithelial cells require p53 to support their long-term function in thymopoiesis in mice. Blood130(4):478-488, 2017. [Journal: Article] [CI: 27] [IF: 15,1]
DOI: 10.1182/blood-2016-12-758961 SCOPUS: 85026293874.
DOI: 10.1182/blood-2016-12-758961 SCOPUS: 85026293874.
Domingues R.G., Lago-Baldaia I., Pereira-Castro I., Fachini J.M., Oliveira L., Drpic D., Lopes N., Henriques T., Neilson J.R., Carmo A.M., Moreira A.,
CD5 expression is regulated during human T-cell activation by alternative polyadenylation, PTBP1, and miR-204. European Journal of Immunology46(6):1490-1503, 2016. [Journal: Article] [CI: 28] [IF: 4,2]
DOI: 10.1002/eji.201545663 SCOPUS: 84973661630.
DOI: 10.1002/eji.201545663 SCOPUS: 84973661630.
Duarte-Pereira S., Pereira-Castro I., Silva S.S., Correia M.G., Neto C., da Costa L.T., Amorim A., Silva R.M.,
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors. Oncotarget7(2):1973-1983, 2016. [Journal: Article] [CI: 50] [IF: 5,2]
DOI: 10.18632/oncotarget.6538 SCOPUS: 84957627325.
DOI: 10.18632/oncotarget.6538 SCOPUS: 84957627325.
Pereira F., Duarte-Pereira S., Silva R.M., Da Costa L.T., Pereira-Castro I.,
Evolution of the NET (NocA, Nlz, Elbow, TLP-1) protein family in metazoans: Insights from expression data and phylogenetic analysis. Scientific Reports6:, 2016. [Journal: Article] [CI: 13] [IF: 4,3]
DOI: 10.1038/srep38383 SCOPUS: 85003583805.
DOI: 10.1038/srep38383 SCOPUS: 85003583805.
Curinha A., Braz S.O., Pereira-Castro I., Cruz A., Moreira A.,
Implications of polyadenylation in health and disease. Nucleus5(6):508-519, 2014. [Journal: Article] [CI: 104] [IF: 3]
DOI: 10.4161/nucl.36360 SCOPUS: 84921902866.
DOI: 10.4161/nucl.36360 SCOPUS: 84921902866.
Pereira-Castro I., Quental R., Da Costa L.T., Amorim A., Azevedo L.,
Successful COG8 and PDF overlap is mediated by alterations in splicing and polyadenylation signals. Human Genetics131(2):265-274, 2012. [Journal: Article] [CI: 4] [IF: 4,6]
DOI: 10.1007/s00439-011-1075-9 SCOPUS: 84856709556.
DOI: 10.1007/s00439-011-1075-9 SCOPUS: 84856709556.