Daniela Vasconcelos

Neuro & Skeletal Circuits

Junior Researcher

Ph.D. (2019) in Molecular and Cellular Biotechnology Applied to Health Sciences (BiotechHealth) from the University of Porto (UP). Her Ph.D work was developed at i3S/INEB/UP, in collaboration with REQUIMTE, Portugal and Biomedical Research Institute of Murcia (IMIB), Spain, and focused on modulation of macrophage response to 3D biomaterials, for bone repair. In the biomaterials field, she provided the 1) the first in vivo characterization of macrophage polarization phenotype in response to 3D implanted biomaterials, chemically different; 2) development of an immunomodulatory material using for the first time an endogenous pro-resolving mediator, able to shift macrophage phenotype; 3) extensive characterization of NLRP3 inflammasome role in response to macroscopic biomaterials. Her research interests are on the crosstalk between neuro and immune cells, particularly on the role of macrophage – sensory nerve cells interplay in cartilage disorders.

Selected Publications

Vasconcelos D.P., Costa M., Neves N., Teixeira J.H., Vasconcelos D.M., Santos S.G., Águas A.P., Barbosa M.A., Barbosa J.N.,

Chitosan porous 3D scaffolds embedded with resolvin D1 to improve in vivo bone healing. Journal of Biomedical Materials Research - Part A106(6):1626-1633, 2018. [Journal: Article] [CI: 24] [IF: 3,2]
DOI: 10.1002/jbm.a.36370 SCOPUS: 85042660127.

Almeida C.R., Caires H.R., Vasconcelos D.P., Barbosa M.A.,

NAP-2 Secreted by Human NK Cells Can Stimulate Mesenchymal Stem/Stromal Cell Recruitment. Stem Cell Reports6(4):466-473, 2016. [Journal: Article] [CI: 52] [IF: 7,3]
DOI: 10.1016/j.stemcr.2016.02.012 SCOPUS: 84963677396.

Vasconcelos D.P., Costa M., Amaral I.F., Barbosa M.A., Águas A.P., Barbosa J.N.,

Development of an immunomodulatory biomaterial: Using resolvin D1 to modulate inflammation. Biomaterials53:566-573, 2015. [Journal: Article] [CI: 71] [IF: 8,4]
DOI: 10.1016/j.biomaterials.2015.02.120 SCOPUS: 84927935709.

Vasconcelos D.P., Costa M., Amaral I.F., Barbosa M.A., Águas A.P., Barbosa J.N.,

Modulation of the inflammatory response to chitosan through M2 macrophage polarization using pro-resolution mediators. Biomaterials37:116-123, 2015. [Journal: Article] [CI: 118] [IF: 8,4]
DOI: 10.1016/j.biomaterials.2014.10.035 SCOPUS: 84922253992.

Vasconcelos D.P., Fonseca A.C., Costa M., Amaral I.F., Barbosa M.A., Águas A.P., Barbosa J.N.,

Macrophage polarization following chitosan implantation. Biomaterials34(38):9952-9959, 2013. [Journal: Article] [CI: 109] [IF: 8,3]
DOI: 10.1016/j.biomaterials.2013.09.012 SCOPUS: 84885383515.

Almeida C.R., Vasconcelos D.P., Gonçalves R.M., Barbosa M.A.,

Enhanced mesenchymal stromal cell recruitment via natural killer cells by incorporation of inflammatory signals in biomaterials. Journal of the Royal Society Interface9(67):261-271, 2012. [Journal: Article] [CI: 55] [IF: 4,9]
DOI: 10.1098/rsif.2011.0357 SCOPUS: 84856583891.